Hostname: page-component-78c5997874-g7gxr Total loading time: 0 Render date: 2024-11-04T21:14:16.315Z Has data issue: false hasContentIssue false
  • English
  • Français

In Situ Characterization of Surface Evolution on Titanium in Hydrogen Peroxide Containing Solutions

Published online by Cambridge University Press:  01 February 2011

Julie J. Muyco ,
Jeremy J. Gray ,
Timothy V. Ratto ,
Christine A. Orme ,
Joanna McKittrick  and
John Frangos
Julie J. Muyco
Affiliation:
Lawrence Livermore National Laboratory, Livermore, CA
Jeremy J. Gray
Affiliation:
Lawrence Livermore National Laboratory, Livermore, CA
Timothy V. Ratto
Affiliation:
Lawrence Livermore National Laboratory, Livermore, CA
Christine A. Orme
Affiliation:
Lawrence Livermore National Laboratory, Livermore, CA
Joanna McKittrick
Affiliation:
University of California, San Diego La Jolla, CA
John Frangos
Affiliation:
La Jolla Bioengineering Institute, La Jolla, CA
Get access

Abstract

Titanium implants have been used for decades with success in various applications. The characteristics of titanium that allows acceptance in the body are not well defined. It is known that hydrogen peroxide is a chemical species produced during the inflammatory response following implantation. When titanium is exposed to hydrogen peroxide, a Ti-peroxy gel (TiOOH) is formed. Three possible functions of Ti-peroxy gel are: reduction of the inflammatory response through the reduction of hydrogen peroxide and other reactive oxygen species; creation of a favorable surface for calcium phosphate nucleation; and as a transitional layer between the soft tissue and the stiff titanium. These studies utilized atomic force microscopy (AFM) force spectroscopy, electrochemical techniques, Raman spectroscopy, and optical transparency in situ to define kinetic and mechanical properties of Ti-peroxy gel as it forms on titanium during exposure to hydrogen peroxide. Peaks attributed to Ti-peroxy gel were seen to emerge over the course of several hours using in situ Raman spectroscopy. Force-distance curves suggest a layer that thickens with time on the titanium sample surface.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 873: Symposium K – Biological and Bio-Inspired Materials and Devices , 2005 , K11.5
Copyright
Copyright © Materials Research Society 2005

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1 Tengvall, P., Lundstron, I., Sjoqvist, L., Elwing, H. & Bjursten, L. M. Titanium-hydrogen peroxide interaction: model studies of the influence of the inflammotry response on titanium implants. Biomaterials 10, 166–175 (1989).Google Scholar
2 Tengvall, P., Vikinge, T. P., Lundstrom, I. & Liedberg, B. FT-Raman Spectroscopic Studies of the Degradation of Titanium Peroxy Gels Made from Metallic Titanium and Hydrogen Peroxide. Journal of Colloid and Interfacial Science 160, 10–15 (1993).Google Scholar
3 Wang, X.-X., Hayakawa, S., Tsuru, K. & Osaka, A. Bioactive titania gel layers formed by chemical treatment of Ti substrate with a H2O2/HCl solution. Biomaterials 23, 1353–1357 (2002).Google Scholar
4 Pham, M. T. et al. Ion beam sensitizing of titanium surfaces to hydroxyapatite formation. Surface and Coatings Technology 128-129, 313–319 (2000).Google Scholar
5 Pham, M. T. Solution deposition of hydroxypatite on titanium pretreated with a sodium ion implantation. Journal of Biomedical Materials Research 59, 716–724 (2002).Google Scholar
6 Nishiguchi, S., Fujibayshi, S., Kim, H.-M., Kokubo, T. & Nakamura, T. Biology of alkali- and heat-treated titanium implants. Journal of Biomedical Materials Research 67A, 26–35 (2003).Google Scholar
7 Ratner, B. D., Hoffman, A. S., Schoen, F. J. & Lemons, J. E. Biomaterials Science: An Introduction to Materials in Medicine (Academic Press, San Diego, 1996).Google Scholar
8 Perizzolo, D., lacefield, W. R. & Brunette, D. M. Interaction between topography and coating in the formation of bone nodules in culture for hydroxyapatite- and titanium-coated micromachined surfaces. Journal of Biomedical Materials Research 56, 494–503 (2001).Google Scholar
9 , Jones, Teeth, F. H. and , bones: applications of surface science to dental materials and related biomaterials. Surface Science Reports 42, 75–205 (2001).Google Scholar
10 Goeransson, A., Jansson, E., Tengvall, P. & Wennerberg, A. Bone formation after 4 weeks around blood-plasma-modified titanium implants with varying surface topographies: an in vivo study. Biomaterials 24, 197–205 (2003).Google Scholar
11 Kuby, J. Immunology (W.H. Freeman and Company, New York, 1997).Google Scholar
12 Muyco, J. J., McKittrick, J., Frangos, J. & Orme, C. in Materials Research Society Spring 2004 Meeting, Symposium W (San Francisco, CA, 2004).Google Scholar
13 Pan, J., Thierry, D. & Leygraf, C. Electrochemical Impedance Spectroscopy Study of the Passive Oxide Film on Titanium for Implant Application. Electrochimica Acta 41, 1143–1153 (1996).Google Scholar