Hostname: page-component-586b7cd67f-t7fkt Total loading time: 0 Render date: 2024-11-25T16:25:48.255Z Has data issue: false hasContentIssue false
  • English
  • Français

Improving Biomaterials from a Cellular Point of View

Published online by Cambridge University Press:  01 February 2011

Venu Gopal Varanasi ,
T. Vallortigara ,
P. M. Loomer ,
E. Saiz ,
A. P. Tomsia ,
S. J. Marshall  and
G. W. Marshall
Venu Gopal Varanasi
Affiliation:
[email protected], University of California, San Francisco, Preventive and Restorative Dental Sciences, 707 Parnassus Avenue, MS 0758, San Francisco, California, 94143-0758, United States, 415-350-4690, 415-476-0858
T. Vallortigara
Affiliation:
[email protected], University of California, San Francisco, Preventive and Restorative Dental Sciences, Division of Biomaterials and Bioengineering, 707 Parnassus Avenue, San Francisco, CA, 94143, United States
P. M. Loomer
Affiliation:
[email protected], University of California, San Francisco, Preventive and Restorative Dental Sciences, Division of Biomaterials and Bioengineering, 707 Parnassus Avenue, San Francisco, CA, 94143, United States
E. Saiz
Affiliation:
[email protected], Lawrence Berkeley National Laboratory, Materials Science Division, 1 Cyclotron Road, MS 62-103, Berkeley, CA, 94720, USA, United States
A. P. Tomsia
Affiliation:
[email protected], Lawrence Berkeley National Laboratory, Materials Science Division, 1 Cyclotron Road, MS 62-103, Berkeley, CA, 94720, USA, United States
S. J. Marshall
Affiliation:
[email protected], University of California, San Francisco, Preventive and Restorative Dental Sciences, Division of Biomaterials and Bioengineering, 707 Parnassus Avenue, San Francisco, CA, 94143, United States
G. W. Marshall
Affiliation:
[email protected], University of California, San Francisco, Preventive and Restorative Dental Sciences, Division of Biomaterials and Bioengineering, 707 Parnassus Avenue, San Francisco, CA, 94143, United States
Get access

Abstract

Bioactive glasses (6P55) used for coating Ti/Ti-alloy were tested for their in vitro behavior in a comparative study with commercial Bioglass™ (45S5) and commercial Ti alloy (Ti6Al4V). In vitro testing included pH and dissolution rate determination in simulated body fluid (SBF) along with in vitro cyto compatibility testing. It was seen in this work that 6P55 and 45S5 had similar dissolution behavior, demonstrating t½ dependence and maximum pH of approximately 8.1 after 10 days of immersion. This pH was reduce by 0.2 0.4 pH units when the in vitro V:A ratio was increased from 1 to 3. The dissolution rate of these glasses approached 0 after additional immersion tests after 15 days and the pH stablilized at less than 7.5. Cell culture studies showed that both glasses behaved in similar fashion after 16 hours in culture. Both glasses had an increase in cell numbers of close to 200-250%, whereas Ti6Al4V had a less pronounced cell number increase (∼ 180%)

Keywords

biologicalcellular (material type)ceramic
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 925: Symposium BB – Mechanotransduction and Engineered Cell-Surface Interactions , 2006 , 0925-BB03-02
Copyright
Copyright © Materials Research Society 2006

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

[1] Hench, L., Journal of the American Ceramic Society, 81, 1705–1728 (1998).Google Scholar
[2] Hench, L. L. and Polak, J. M., Science, 295, 1014–+ (2002).Google Scholar
[3] Hench, L. L. and Wilson, J., Science, 226, 630–636 (1984).Google Scholar
[4] Fujishiro, Y., Hench, L. L., and Oonish, H., Journal of Materials Science: Materials in Medicine, 8, 649–652 (1997).Google Scholar
[5] Wilson, J. and Low, S. B., Journal of Applied Biomaterials, 3, 123–129 (1992).Google Scholar
[6] Jones, J. R., Sepulveda, P., and Hench, L. L., Journal of Biomedical Materials Research, 58, 720–726 (2001).Google Scholar
[7] Pazo, A., Saiz, E., and Tomsia, A. P., Acta Materialia, 46, 2551–2558 (1998).Google Scholar
[8] Saiz, E., Goldman, M., Gomez-Vega, J. M., Tomsia, A. P., Marshall, G. W., and Marshall, S. J., Biomaterials, 23) 3749–3756 (2002).Google Scholar
[9] Cerruti, M. G., Greenspan, D., and Powers, K., Biomaterials, 26, 4903–4911 (2005).Google Scholar
[10] Foppiano, S., Marshall, S. J., Eduardo Saiz, b, Tomsia, A. P., and Marshall, G. W., Acta Biomaterialia, xxx, xxx–xxx (2006).Google Scholar
[11] El-Ghannam, A., Ducheyne, P., and Shapiro, I. M., Journal of Biomedical Materials Research, 29, 359–370 (1995).Google Scholar
[12] Sepulveda, P., Jones, J. R., and Hench, L. L., Bioceramics, 192–1, 629–633 (2000).Google Scholar
[13] Quarles, L. D., Yohay, D. A., Lever, L. W., Caton, R., and Wenstrup, R. J., Journal of Bone and Mineral Research, 7, 683–692 (1992).Google Scholar
[14] Foppiano, S., Marshall, S. J., Marshall, G. W., Saiz, E., and Tomsia, A. P., Journal of Biomedical Material Research A, 71A, 242–249 (2004).Google Scholar
[15] Brauer, D. S., Russel, C., Li, W., and Habelitz, S., Journal of Biomedical Material Research A, 77A, 213–219 (2006).Google Scholar
[16] Kim, H.-M., Miyaji, F., Kokubo, T., Ohtsuki, C., and Nakamura, T., Journal of the American Ceramic Society, 78, 2405–2411. (1995).Google Scholar
[17] Zreiqat, H., Shakibaei, M. E., Evans, P., Knabe, C., and Howlett, C. R., Journal of Bone and Mineral Research, 16, S328–S328 (2001).Google Scholar