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Imaging of gold dendrimer nanocomposites in cells

Published online by Cambridge University Press:  21 March 2011

Jonathan D. Eichman ,
Mohamed K. Khan ,
Inhan Lee ,
James R. Baker Jr ,
Theodore S. Lawrence ,
Dorothy R. Sorenson ,
Chris A. Edwards  and
Lajos Balogh
Jonathan D. Eichman
Affiliation:
Center for Biologic Nanotechnology, University of Michigan, Ann Arbor, MI 48109-0533
Mohamed K. Khan
Affiliation:
Department of Cell & Development Biology, University of Michigan, Ann Arbor, MI 48109-0533
Inhan Lee
Affiliation:
Center for Biologic Nanotechnology, University of Michigan, Ann Arbor, MI 48109-0533
James R. Baker Jr
Affiliation:
Center for Biologic Nanotechnology, University of Michigan, Ann Arbor, MI 48109-0533
Theodore S. Lawrence
Affiliation:
Department of Cell & Development Biology, University of Michigan, Ann Arbor, MI 48109-0533
Dorothy R. Sorenson
Affiliation:
Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109-0533
Chris A. Edwards
Affiliation:
Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109-0533
Lajos Balogh
Affiliation:
Department of Cell & Development Biology, University of Michigan, Ann Arbor, MI 48109-0533 Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109-0533
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Abstract

Dendrimer nanocomposites (DNC) are hybrid nanoparticles formed by the dispersion and immobilization of guest atoms or small clusters in dendrimer matrices. They have a great potential in biomedical applications due to their controlled composition, predetermined size, shape and surface functionalities. In this work, nanocomposites of gold and poly(amidoamine) dendrimers {Au(0)n-PAMAM} have been selected to demonstrate this nanoparticle based concept. {Au(0)n-PAMAM} gold dendrimer nanocomposites with a well-defined size have been synthesized and imaged by TEM both in vitro and in vivo. Dendrimer nanocomposites have also the potential to be used as drug delivery vehicles either utilizing bioactive guests or incorporating radioactive isotopes. Radioactive dendrimer nanocomposites, e.g. {198-Au}, can be delivered to the tumor either by means of injecting the active nanoparticles directly into the tumor microvasculature or by intravenous injection. Both specific or non-specific targeting can be utilized in this process to achieve appropriate transfer.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 676: Symposium Y – Synthesis, Functional Properties and Applications of Nanostructures , 2001 , Y9.3
Copyright
Copyright © Materials Research Society 2001

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