Hostname: page-component-586b7cd67f-t7fkt Total loading time: 0 Render date: 2024-11-23T07:18:39.746Z Has data issue: false hasContentIssue false
  • English
  • Français

Functionalization of Nanofibrous Spiral Structured Scaffolds for Bone Tissue Engineering

Published online by Cambridge University Press:  31 January 2011

Junping Wang  and
Xiaojun Yu
Junping Wang
Affiliation:
[email protected], Stevens Institute of Technology, Biomedical Engineering, Hoboken, New Jersey, United States
Xiaojun Yu
Affiliation:
[email protected], Stevens Institute of Technology, Biomedical Engineering, Hoboken, New Jersey, United States
Get access

Abstract

In the previous studies, we have successfully developed a novel spiral structured nanofibrous scaffolds with improved osteoconductivity for bone tissue engineering. The spiral structure design facilitates the nutrient transport and waste removal, and allows uniform cellular growth and distribution within the scaffolds, thus enhanced the bioactivity of the scaffolds. In this chapter, HAP and BMP-2 were incorporated within the nanofibrous spiral scaffolds in order to enhance the osteoinductivity of the established system. The effect of the blending materials was evaluated through cell proliferation, cell differentiation of human osteoblast cells seeded on the scaffolds and cultured for 4 and 8 days. The results has demonstrated that the functionalization of PCL nanofibrous spiral scaffolds leads to higher ALP expression level and increased amount of mineralization level however lower cell proliferation rate.

Keywords

bonenanostructurebiomaterial
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1235: Symposium RR – Engineering Biomaterials for Regenerative Medicine , 2009 , 1235-RR03-41
Copyright
Copyright © Materials Research Society 2010

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1 Wang, J, CM, Valmikinathan, Liu, W, CT, Laurencin, Yu, X J Biomed Mater Res A. 2009 Jul 29Google Scholar
2 Supová, M J Mater Sci Mater Med. 2009 Jun;20(6):1201–13.Google Scholar
3 GL, Converse, TL, Conrad, RK, Roeder. J Mech Behav Biomed Mater. 2009 Dec;2(6):627–35.Google Scholar
4 CI, Boissard, PE, Bourban, AE, Tami, Alini, M, Eglin, D. 2009 Nov;5(9):3316-27.Google Scholar
5 Guarino, V, Taddei, P, Di Foggia, M, Fagnano, C, Ciapetti, G, Ambrosio, L. Tissue Eng Part A. 2009 Jun 4.Google Scholar
6 Xiao, X, Liu, R, Huang, Q, Ding, X J Mater Sci Mater Med. 2009 Jul 2Google Scholar
7 Causa, F, PA, Netti, Ambrosio, L, Ciapetti, G, Baldini, N, Pagani, S, Martini, D, Giunti, A. J Biomed Mater Res A. 2006 Jan;76(1):151–62.Google Scholar
8 JR, Venugopal, Low, S, AT, Choon, AB, Kumar, Ramakrishna, S Artif Organs. 2008 May;32(5):388–97.Google Scholar
9 KH, Tan, CK, Chua, KF, Leong, CM, Cheah, WS, Gui, WS, Tan, FE, Wiria. Biomed Mater Eng. 2005;15(1-2):113–24.Google Scholar
10 Taddei, P, Di Foggia, M, Causa, F, Ambrosio, L, Fagnano, C Int J Artif Organs. 2006 Jul;29(7):719–25Google Scholar
11 Fabbri, P, Bondioli, F, Messori, M, Bartoli, C, Dinucci, D, Chiellini, F J Mater Sci Mater Med. 2009 Aug 4Google Scholar
12 Nadra, I, AR, Boccaccini, Philippidis, P, LC, Whelan, GM, McCarthy, DO, Haskard, RC, Landis. 2008 J Mater Sci Mater Med Jan;196(1):98–105 Google Scholar
13 JM, Curran, JA, Gallagher, JA, Hunt. 2005 Sep;26(26):5313-20Google Scholar
14 Dong, X, Wang, Q, Wu, T, Pan, H. Biophys J. 2007 Aug 1;93(3):750–9.Google Scholar
15 Ono, I, Gunji, H, Kaneko, F, Saito, T, Kuboki, Y. J Craniofac Surg. 1995 May;6(3):238–44.Google Scholar
16 Kamegai, A, Shimamura, N, Naitou, K, Nagahara, K, Kanematsu, N, Mori, M. Biomed Mater Eng. 1994;4(4):291–307.Google Scholar
17 Ono, I, Ohura, T, Murata, M, Yamaguchi, H, Ohnuma, Y, Kuboki, Y. Plast Reconstr Surg. 1992 Nov;90(5):870–9.Google Scholar
18 Yu, H, HW, Matthew, PH, Wooley, SY, Yang. J Biomed Mater Res B Appl Biomater. 2008 Aug;86B(2):541–7.Google Scholar