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Functional design of porous drug delivery systems based on laser assisted manufactured nitinol

Published online by Cambridge University Press:  09 January 2012

Igor V. Shishkovsky
Igor V. Shishkovsky*
Affiliation:
P.N. Lebedev Physics Institute of Russian Academy of Sciences, Samara branch, Novo-Sadovaja st. 221, Samara 443011, Russia. [email protected]
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Abstract

Our previous studies proved the occurrence of the shape memory effect (SME) in a biocompatible porous nitinol (inter-metallic phase NiTi), obtained by the selective laser sintering (SLS) method. In this report we propose to use the SME peculiar to the nitinol, for a functional design of the drug delivery system and to discuss the process flow pattern. In living tissues (flesh) the elevated temperature at the disease origination leads to the nitinol pores size reduction caused by the austenite phase transformation, and to the pharmaceutical composition extrusion from the pores. And vice versa, during the cooling stage when the tissue temperature reverts to normal level, the drug intake will stop. Depending on the type of the three dimensional structure of a porous matrix (scaffold) identified at the stage of a computer-aid-design, the velocity of penetration can be controllable.

Keywords

microelectro-mechanical (MEMS)biomaterialfluidics
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1415: Symposium HH/II/TT – MEMS, BioMEMS and Bioelectronics–Materials and Devices , 2012 , mrsf11-1415-ii03-10
Copyright
Copyright © Materials Research Society 2012

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References

REFERENCES

1. Hilt, J.Z., Peppas, N.A.. International Journal of Pharmaceutics, 306, 15, (2005).Google Scholar
2. Lu, C.. PhD. Thesis , Ohio State University, 2006.Google Scholar
3. Shishkovsky, I.V.. Technical Physics Letters, 31 (3), 186, (2005).Google Scholar
4. Guo, S.-R., Wang, Z.-M., Zhang, Y.-Q. et al. . Journal of Pharmaceutical Sciences, 99 (7), 3009, (2010).Google Scholar
5. Dake, M.D., Van Alstine, W.G., Zhou, Q., Ragheb, A.O.. J. Vasc. Interv. Radiol. 22, 603, (2011).Google Scholar
6. Sato, S., Nakayama, Y., Miura, Y. et al. . Journal of Biomedical Materials Research - Part B. Applied Biomaterials, 83 (2), 345, (2007).Google Scholar
7. Shishkovsky, I.V., Kuznetsov, M. V., and Morozov, Yu. G.. International Journal of Self Propagating High Temperature Synthesis, 19 (2), 157, (2010).Google Scholar
8. Moore, J.L., McCuiston, A., Mittendorf, I., Ottway, R. and Johnson, R.D.. Microfluidics and Nanofluidics, 10 (4), 877, (2010).Google Scholar
9. Arutyunov, Y.I., Zhuravel, L.V., Pokoev, A.V. et al. . Physics of metals and metallography, 93 (2), 185, (2002).Google Scholar
10. Ochon´ski, W.. Industrial Lubrication and Tribology, 62 (2), 99, (2010).Google Scholar
11. Gunter, V.E. Eds. Medical materials and implants with shape memory effect. Proceedings of the Research Institute for medical material implant at the Tomsk State University. Tomsk Univ. Pub. (1998).Google Scholar