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Ferroelectric-Specific Peptides as Building Blocks for Bio-Inorganic Devices

Published online by Cambridge University Press:  01 February 2011

Brian Dennis Reiss ,
Leonidas Ocola ,
Orlando Auciello  and
Millicent A. Firestone
Brian Dennis Reiss
Affiliation:
[email protected], Argonne National Laboratory, Center for Nanoscale Materials and Materials Science Division, 9700 S. Cass Ave., Argonne, IL, 60439, United States
Leonidas Ocola
Affiliation:
[email protected], Argonne National Laboratory, Center for Nanoscale Materials, 9700 S. Cass Ave., Argonne, IL, 60439, United States
Orlando Auciello
Affiliation:
[email protected], Argonne National Laboratory, Center for Nanoscale Materials, 9700 S. Cass Ave., Argonne, IL, 60439, United States
Millicent A. Firestone
Affiliation:
[email protected], Argonne National Laboratory, Center for Nanoscale Materials, 9700 S. Cass Ave., Argonne, IL, 60439, United States
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Abstract

The integration of biomolecules with inorganic materials to create functional composites represents a critical step in the development of next-generation biosensors, micro/nanofluidic devices, and biochips that require a combination of abiotic (inorganics) and biotic (proteins, DNA, antibodies) components. Toward this end, we have previously applied combinatorial phage display techniques to identify a constrained heptapeptide sequence (CISLLHSTC) that selectively binds to a perovskite ferroelectric (MOCVD-deposited lead zirconium titanate, PZT). In this work, we examine the binding of this heptapeptide sequence, prepared by solid phase peptide synthesis to sol-gel PZT. In particular, the surface roughness has been examined and the long-term stability of the PZT films in biological buffered aqueous solutions by atomic force microscopy, X-ray diffraction and P-E hysteresis loop. In addition, the selectivity of the peptide binding to PZT has been determined by immunofluorescence microscopy and the nature of peptide binding to the PZT surface is probed by X-ray photoemission spectroscopy.

Keywords

biomimetic (assembly)ferroelectricfluidics
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 944: Symposium AA – Molecular Motors, Nanomachines, and Engineered Bio-Hybrid Systems , 2006 , 0944-AA02-08
Copyright
Copyright © Materials Research Society 2006

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