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The Evolution and Application of Regenerative Engineering

Published online by Cambridge University Press:  19 August 2014

Roshan James  and
Cato T. Laurencin
Roshan James
Affiliation:
Institute for Regenerative Engineering, University of Connecticut Health Center, Farmington, Connecticut 06030, USA Raymond and Beverly Sackler Center for Biological, Physical and Engineering Sciences, University of Connecticut Health Center, Connecticut 06030, USA Department of Orthopaedic Surgery, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
Cato T. Laurencin*
Affiliation:
Institute for Regenerative Engineering, University of Connecticut Health Center, Farmington, Connecticut 06030, USA Raymond and Beverly Sackler Center for Biological, Physical and Engineering Sciences, University of Connecticut Health Center, Connecticut 06030, USA Department of Orthopaedic Surgery, University of Connecticut Health Center, Farmington, Connecticut 06030, USA Connecticut Institute for Clinical and Translational Science, Farmington, Connecticut 06030, USA Department of Chemical, Materials and Biomolecular Engineering, University of Connecticut, Storrs, Connecticut 06269, USA
*
*Email: [email protected]
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Abstract

Current treatment options for tissue loss or organ failure include organ/tissue transplantation of autografts/allografts, delivery of bioactive agents, and utilization of synthetic replacements composed of metals, polymers, and ceramics. However each strategy suffers from a number of limitations. The early attempts to overcome these drawbacks led to the emergence of tissue engineering that provided viable tissue substitutes using a combination of biomaterials, cells, and factors. This approach was ideally suited to repair damaged tissues; however the substitution and regeneration of large tissue volumes and multi-level tissues such as complex organ systems require more than optimal combinations of biomaterials and biologics.

‘Regenerative Engineering’ is aimed at creating large and complex tissue systems incorporating advances in material science, stem cell technology and developmental biology. We believe that recent breakthrough technologies in advanced materials science and nanotechnology allow us to recapitulate native tissues. The novel designer polymers incorporate bioactivity and physical features specific to a regeneration application. Overall, engineered materials and scaffolds afford selective control of cell sensitivity, and precise control of temporal and spatial stimulatory cues. We aim to build multi-level systems such as organs through location-specific topographies and physico-chemical cues incorporated into a continuous phase using a combination of classical top-down tissue engineering approach with bottom-up strategies used in regenerative biology.

Musculoskeletal tissues are critical to the normal functioning of an individual and following damage or degeneration show extremely limited endogenous regenerative capacity. The development of material and structural platforms to modulate stem cell behavior to enhance regeneration is an area of great interest. In this manuscript we cover some examples of material development, and incorporation of topographical and cytokine cues to modulate the differentiation of hard and soft musculoskeletal tissues such as bone, ligament and tendon.

Keywords

biomaterialnanoscalebone
Type
Articles
Information
MRS Online Proceedings Library (OPL) , Volume 1687: Symposium W – Functional Biomaterials for Regenerative Engineering , 2014 , mrss14-1687-w07-09
Copyright
Copyright © Materials Research Society 2014 

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References

REFERENCES

Fung, Y., “A proposal to the National science Foundation for An Engineering Research Centre at USCD,” Center for the Engineering of Living Tissues. UCSD, vol. 865023, 2001.Google Scholar
Langer, R. and Vacanti, J., “Tissue engineering,” Science, vol. 260, pp. 920-926, May 14, 1993 1993.CrossRefGoogle ScholarPubMed
Nair, L. S. and Laurencin, C. T., “Biodegradable polymers as biomaterials,” Progr Polymer Sci vol. 32, pp. 762–798, 2007.CrossRefGoogle Scholar
Bauer, T. W. and Muschler, G. F., “Bone graft materials: an overview of the basic science,” Clinical orthopaedics and related research, vol. 371, p. 10, 2000.CrossRefGoogle Scholar
Laurencin, C. and Khan, Y., “Regenerative engineering,” Science translational medicine, vol. 4, pp. 160ed9-160ed9, 2012.CrossRefGoogle ScholarPubMed
Laurencin, C. T. and Khan, Y., “Regenerative Engineering,” Science Translational Medicine, vol. 4, p. 160ed9, November 14, 2012 2012.Google Scholar
James, R., Daley, G. Q., and Laurencin, C. T., “Regenerative Engineering: Materials, Mimicry, and Manipulations to Promote Cell and Tissue Growth,” National Academy of Engineering - The Bridge: The Convergence of Engineering and the Life Sciences; Editors: Philip A. Sharp and Robert Langer, vol. 43, p. 8, 2013.Google Scholar
Sharp, P. A. and Langer, R., “Promoting Convergence in Biomedical Science,” Science, vol. 333, p. 527, July 29, 2011 2011.CrossRefGoogle ScholarPubMed
Reichert, W., Ratner, B. D., Anderson, J., Coury, A., Hoffman, A. S., Laurencin, C. T., et al. ., “2010 Panel on the biomaterials grand challenges,” Journal of Biomedical Materials Research Part A, vol. 96, pp. 275–287, 2011.CrossRefGoogle ScholarPubMed
Langer, R. and Tirrell, D. A., “Designing materials for biology and medicine,” Nature, vol. 428, pp. 487–492, 2004/04/01/print 2004.CrossRefGoogle ScholarPubMed
Anderson, D. G., Levenberg, S., and Langer, R., “Nanoliter-scale synthesis of arrayed biomaterials and application to human embryonic stem cells,” Nature biotechnology, vol. 22, pp. 863–866, 2004.CrossRefGoogle ScholarPubMed
Peerani, R., Rao, B. M., Bauwens, C., Yin, T., Wood, G. A., Nagy, A., et al. ., “Niche-mediated control of human embryonic stem cell self-renewal and differentiation,” EMBO J, vol. 26, pp. 4744–55, Nov 14 2007.CrossRefGoogle ScholarPubMed
Shelke, N. B., James, R., Laurencin, C. T., and Kumbar, S. G., “Polysaccharide biomaterials for drug delivery and regenerative engineering,” Polymers for Advanced Technologies, pp. n/a-n/a, 2014.CrossRefGoogle Scholar
Desai, D., Rinaldi, F., Kothari, S., Paruchuri, S., Li, D., Lai, M., et al. ., “Effect of hydroxypropyl cellulose (HPC) on dissolution rate of hydrochlorothiazide tablets,” Int J Pharm, vol. 308, pp. 40–5, Feb 3 2006.CrossRefGoogle ScholarPubMed
Lin, W. C., Lien, C. C., Yeh, H. J., Yu, C. M., and Hsu, S. H., “Bacterial cellulose and bacterial cellulose-chitosan membranes for wound dressing applications,” Carbohydrate Polymers, vol. 94, pp. 603–611, Apr 2013.CrossRefGoogle ScholarPubMed
Ferrero, C., Massuelle, D., and Doelker, E., “Towards elucidation of the drug release mechanism from compressed hydrophilic matrices made of cellulose ethers. II. Evaluation of a possible swelling-controlled drug release mechanism using dimensionless analysis,” Journal of Controlled Release, vol. 141, pp. 223–233, Jan 2010.CrossRefGoogle ScholarPubMed
Borden, M., Attawia, M., Khan, Y., and Laurencin, C. T., “Tissue engineered microsphere-based matrices for bone repair::: design and evaluation,” Biomaterials, vol. 23, pp. 551–559, 2002.CrossRefGoogle ScholarPubMed
Jiang, T., Abdel-Fattah, W. I., and Laurencin, C. T., “In vitro evaluation of chitosan/poly(lactic acid-glycolic acid) sintered microsphere scaffolds for bone tissue engineering,” Biomaterials, vol. 27, pp. 4894–903, Oct 2006.CrossRefGoogle ScholarPubMed
Aravamudhan, A., Ramos, D. M., Nip, J., Harmon, M., James, R., Deng, M., et al. ., “Cellulose and Collagen Derived Micro-Nano Structured Scaffolds for Bone Tissue Engineering,” J Biomed Nanotechnol, vol. 9, pp. 1–13, Dec 2013 (in press) .CrossRefGoogle ScholarPubMed
Kumbar, S. G., Toti, U. S., Deng, M., James, R., Laurencin, C. T., Aravamudhan, A., et al. ., “Novel mechanically competent polysaccharide scaffolds for bone tissue engineering,” Biomed Mater, vol. 6, p. 065005, Dec 2011.CrossRefGoogle ScholarPubMed
Cooper, J. A., Sahota, J. S., Gorum, W. J., Carter, J., Doty, S. B., and Laurencin, C. T., “Biomimetic tissue-engineered anterior cruciate ligament replacement,” Proceedings of the National Academy of Sciences, vol. 104, p. 3049, 2007.CrossRefGoogle ScholarPubMed
Cooper, J. A. Jr, Bailey, L. O., Carter, J. N., Castiglioni, C. E., Kofron, M. D., Ko, F. K., et al. ., “Evaluation of the anterior cruciate ligament, medial collateral ligament, achilles tendon and patellar tendon as cell sources for tissue-engineered ligament,” Biomaterials, vol. 27, pp. 2747–2754, 5// 2006.CrossRefGoogle ScholarPubMed
Lu, H. H., Cooper, J. A. Jr, Manuel, S., Freeman, J. W., Attawia, M. A., Ko, F. K., et al. ., “Anterior cruciate ligament regeneration using braided biodegradable scaffolds: in vitro optimization studies,” Biomaterials, vol. 26, pp. 4805–4816, 2005.CrossRefGoogle ScholarPubMed
Cooper, J. A., Lu, H. H., Ko, F. K., Freeman, J. W., and Laurencin, C. T., “Fiber-based tissue-engineered scaffold for ligament replacement: design considerations and in vitro evaluation,” Biomaterials, vol. 26, pp. 1523–1532, May 2005.CrossRefGoogle ScholarPubMed
Maffulli, N., Ajis, A., Longo, U. G., and Denaro, V., “Chronic rupture of tendo Achillis,” Foot and ankle clinics, vol. 12, pp. 583–96, vi, Dec 2007.CrossRefGoogle ScholarPubMed
Maffulli, N., Longo, U. G., Gougoulias, N., and Denaro, V., “Ipsilateral free semitendinosus tendon graft transfer for reconstruction of chronic tears of the Achilles tendon,” BMC musculoskeletal disorders, vol. 9, p. 100, 2008.CrossRefGoogle ScholarPubMed
Maffulli, N. and Ajis, A., “Management of chronic ruptures of the Achilles tendon,” Journal of Bone and Joint Surgery-American Volume, vol. 90A, pp. 1348–1360, Jun 2008.CrossRefGoogle Scholar
Longo, U. G., Lamberti, A., Maffulli, N., and Denaro, V., “Tissue engineered biological augmentation for tendon healing: a systematic review,” British medical bulletin, Sep 17 2010.CrossRefGoogle ScholarPubMed
Longo, U. G., Lamberti, A., Maffulli, N., and Denaro, V., “Tendon augmentation grafts: a systematic review,” British medical bulletin, vol. 94, pp. 165–88, 2010.CrossRefGoogle ScholarPubMed
Aurora, A., McCarron, J., Iannotti, J. P., and Derwin, K., “Commercially available extracellular matrix materials for rotator cuff repairs: state of the art and future trends,” Journal of shoulder and elbow surgery / American Shoulder and Elbow Surgeons... [et al.], vol. 16, pp. S171–8, Sep-Oct 2007.CrossRefGoogle ScholarPubMed
Chen, J. M., Xu, J. K., Wang, A. L., and Zheng, M. H., “Scaffolds for tendon and ligament repair: review of the efficacy of commercial products,” Expert Review of Medical Devices, vol. 6, pp. 61–73, Jan 2009.CrossRefGoogle ScholarPubMed
Derwin, K. A., Baker, A. R., Spragg, R. K., Leigh, D. R., and Iannotti, J. P., “Commercial extracellular matrix scaffolds for rotator cuff tendon repair - Biomechanical, biochemical, and cellular properties,” Journal of Bone and Joint Surgery-American Volume, vol. 88A, pp. 2665–2672, Dec 2006.CrossRefGoogle Scholar
Kumbar, S., James, R., Nukavarapu, S., and Laurencin, C., “Electrospun nanofiber scaffolds: engineering soft tissues,” Biomedical Materials, vol. 3, p. 034002, 2008.CrossRefGoogle ScholarPubMed
James, R., Kumbar, S. G., Laurencin, C. T., Balian, G., and Chhabra, A. B., “Tendon tissue engineering: adipose-derived stem cell and GDF-5 mediated regeneration using electrospun matrix systems,” Biomedical materials, vol. 6, p. 025011, Apr 2011.CrossRefGoogle ScholarPubMed
James, R., Kesturu, G., Balian, G., and Chhabra, A. B., “Tendon: Biology, biomechanics, repair, growth factors, and evolving treatment options,” Journal of Hand Surgery-American Volume, vol. 33A, pp. 102–112, Jan 2008.CrossRefGoogle Scholar
Hogan, M. V., Bagayoko, N., James, R., Starnes, T., Katz, A., and Chhabra, A. B., “Tissue engineering solutions for tendon repair,” J Am Acad Orthop Surg, vol. 19, pp. 134–42, Mar 2011.CrossRefGoogle ScholarPubMed