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Eukaryotic Signal Transduction Pathways And Man-Made Systems Compared

Published online by Cambridge University Press:  21 February 2011

Hagan Bayley
Hagan Bayley*
Affiliation:
Worcester Foundation for Experimental Biology. 222 Maple Avenue, Shrewsbury, MA 01545
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Abstract

The components of biological signal transduction pathways have been compared with those of electronic circuits. Indeed, attempts are being made to incorporate biomolecules into electronic devices. However, man-made biomolecular devices do not yet mimic several important features of naturally occurring systems, especially those of eukaryotes. It is well known that the polypeptide components of biological signal transduction pathways include subunits of receptors, regulatory proteins, enzymes and channels. It is less well appreciated that each component often exists in many functionally related but not redundant forms. When proteins are hetero-oligomers, numerous combinations of these forms may be permitted yielding large arrays of signal transduction molecules with overlapping properties. Further, the organization of these molecules within the cell Is highly complex. Especially alien to the materials scientist are the findings that signal transductlon proteins can translocate between regions of cells in response to stimuli and change in concentration as a consequence of breakdown and resynthesis. These features, as well as the interactions between signal transduction pathways, produce far more complex and fluid signalling networks than those presently used in man-made devices. Is anything to be gained by mimicking such complexity or are we on the right track in designing relatively simple, structurally rigid devices using biomolecular components?

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 255: Symposium Z – Hierarchically Structured Materials , 1991 , 269
Copyright
Copyright © Materials Research Society 1992

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