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Enhanced Vascular Endothelial Cell Function on Nanostructured Titanium Surface Features: The Role of Nano to Submicron Roughness

Published online by Cambridge University Press:  15 March 2011

Jing Lu ,
Dongwoo Khang  and
Thomas J. Webster
Jing Lu
Affiliation:
Division of Engineering and Department of Orthopaedic Surgery, Brown University, Providence, RI 02912, USA
Dongwoo Khang
Affiliation:
Division of Engineering and Department of Orthopaedic Surgery, Brown University, Providence, RI 02912, USA
Thomas J. Webster
Affiliation:
Division of Engineering and Department of Orthopaedic Surgery, Brown University, Providence, RI 02912, USA
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Abstract

To study the contribution of different surface feature properties in improving vascular endothelial cell adhesion, rationally designed nano/sub-micron patterns with various dimensions were created on titanium surfaces in this study. In vitro results indicated that endothelial cell adhesion was improved when the titanium pattern dimensions decreased into the nano-scale. Specifically, endothelial cells preferred to adhere on sub-micron and nano rough titanium substrates compared to flat titanium. Moreover, titanium with nano and sub-micron roughness and with the same chemistry as compared to flat titanium, had significantly greater surface energy. Thus, the present study indicated the strong potential of surface nanotopography and nano/sub-micron roughness for improving current vascular stent design.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1136: Symposium DD – Materials in Tissue Engineering , 2008 , 1136-DD04-04
Copyright
Copyright © Materials Research Society 2009

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References

REFERENCES

1.Cardiovascular Disease Statistics, American Heart Association, 2004 Google Scholar
2. Anne, Issel Lim, L.. MURJ, 11:33–7 (2004)Google Scholar
3. Hara, H, Masato, NM, Palmaz, JC, Schwartz, RS. Advanced Drug Delivery Reviews 58, 350–357 (2006)Google Scholar
4. Mario, C Di, Marsico, F, Adamian, M, Karvouni, E, Albiero, R, Colombo, A. Heart 84, 471–475 (2000)Google Scholar
5. Stone, GW, Ellis, SG, Cox, DA, Hermiller, J, O'Shaughnessy, C, Mann, JT. Circulation 109, 1942–7 (2004)Google Scholar
6. Chung, TW, Liu, DZ, Wang, SY, Wang, SS. Biomaterials 24, 4655–4661 (2003)Google Scholar
7. J Lu, J, Rao, MP, MacDonald, NC, Khang, D, Webster, TJ. Acta Biomaterialia 4, 192–201 (2008)Google Scholar
8. Moses, JW, Leon, MB, Popma, JJ, Fitzgerald, PJ, Holmes, DR, O'Shaughnessy, C Engl, C. N J Med 349, 1315–23 (2003)Google Scholar
9. Khang, D, Lu, J, Yao, C, Haberstroh, KM, Webster, TJ. Biomaterials 29, 970–83 (2008).Google Scholar
10. Singhvi, R, Kumar, A, Lopez, GP, Stephanopoulos, GN, Wang, DI, Whitesides, GM, Ingber, DE. Science 264, 696–8 (1994).Google Scholar
11. Brunette, DM, Kenner, GS, Gould, TR. J Dent Res 62, 1045–8 (1983).Google Scholar
12. Palmaz, JC, Benson, A, Eugene, A. J Vasc Interv Radiol 10, 439–44 (1999).Google Scholar