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Electro-Optical Detection of Single Nanoparticles on a Nanopore-Optofluidic Chip

Published online by Cambridge University Press:  30 December 2014

Shuo Liu ,
Yue Zhao ,
Matthew Stott ,
Joshua W. Parks ,
Aaron R. Hawkins  and
Holger Schmidt
Shuo Liu
Affiliation:
School of Engineering, University of California, Santa Cruz, 1156 High Street, Santa Cruz, CA 95064 USA
Yue Zhao
Affiliation:
Department of Electrical & Computer Engineering, 459 Clyde Building, Brigham Young University, Provo, UT 84602 USA
Matthew Stott
Affiliation:
Department of Electrical & Computer Engineering, 459 Clyde Building, Brigham Young University, Provo, UT 84602 USA
Joshua W. Parks
Affiliation:
School of Engineering, University of California, Santa Cruz, 1156 High Street, Santa Cruz, CA 95064 USA
Aaron R. Hawkins
Affiliation:
Department of Electrical & Computer Engineering, 459 Clyde Building, Brigham Young University, Provo, UT 84602 USA
Holger Schmidt
Affiliation:
School of Engineering, University of California, Santa Cruz, 1156 High Street, Santa Cruz, CA 95064 USA
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Abstract

A solid-state nanopore was integrated into an optofluidic sensor chip, liquid-core anti-resonant reflecting optical waveguide (ARROW). The solid-state nanopore worked as a smart gate, which simultaneously provided characteristic electrical signals and controlled the entry of single nanoparticles into the liquid-core channel. The subsequent fluorescence detection further identified the nanoparticles by providing optical signals within a specific wavelength range. In this work, correlated electrical and optical detection of single nanoparticles, H1N1 viruses, and λ-DNA molecules was demonstrated. Different types of particles in a mixture were successfully discriminated. Moreover, the flow velocity in the liquid-core channel was extracted with the help of combined analysis of electrical and optical signals. Enhanced electrical sensitivity using a solid-state nanopore with a thin limiting aperture sculpted by SiO2 deposition was also shown.

Keywords

sensornanoscaleoptoelectronic
Type
Articles
Information
MRS Online Proceedings Library (OPL) , Volume 1720: Symposium D – Materials and Concepts for Biomedical Sensing , 2014 , mrsf14-1720-d09-02
Copyright
Copyright © Materials Research Society 2014 

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