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Electrically Modulated Drug Delivery using Nanoporous Electrodes

Published online by Cambridge University Press:  31 January 2011

David B. Robinson ,
Shaun D. Gittard ,
C.-A. Max Wu ,
Cindy M. Ha  and
Roger J. Narayan
David B. Robinson
Affiliation:
[email protected], Sandia National Laboratories, PO Box 969 MS 9291, Livermore, California, 94551, United States
Shaun D. Gittard
Affiliation:
[email protected], University of North Carolina, Chapel Hill, North Carolina, United States
C.-A. Max Wu
Affiliation:
[email protected], Sandia National Laboratories, Livermore, California, United States
Cindy M. Ha
Affiliation:
[email protected], University of North Carolina, Chapel Hill, North Carolina, United States
Roger J. Narayan
Affiliation:
[email protected], University of North Carolina, Biomedical Engineering, Chapel Hill, North Carolina, 27599, United States
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Abstract

Nanoporous electrodes, such as those made from carbon or gold, can capture and release ionic analytes at concentrations near 1 mole per liter of pore volume through capacitive charging or electrochemically reversible adsorption. In vitro studies suggest that this phenomenon can be the basis for a noninvasive, precise, and programmable drug delivery method. It would eliminate the need for bulk fluid delivery to target tissue and require only a thin electrical connection, minimizing pain and tissue disruption. We have designed effective gold electrode assemblies and observed the depletion and release phenomena using electrochemical methods and charged dyes.

Keywords

biomedicalchemical reactionnanostructure
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1239: Symposium VV – Micro- and Nanoscale Processing of Biomaterials , 2009 , 1239-VV08-03
Copyright
Copyright © Materials Research Society 2010

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