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Effect of the Sol-Gel Synthesis Parameters on the Incorporation of an Anti-inflammatory Drug in a Ceramic Material

Published online by Cambridge University Press:  17 March 2011

Aracely Hernandez ,
Patricia Esquivel-Ferriño ,
Idalia Gomez  and
Lucia Cantu
Aracely Hernandez
Affiliation:
Fac. de Ciencias Químicas, Universidad Autonoma de Nuevo Leon, Av. Pedro de Alba s/n, Cd. Universitaria, San Nicolás de los Garza, N.L., 66400, Mexico
Patricia Esquivel-Ferriño
Affiliation:
Fac. de Ciencias Químicas, Universidad Autonoma de Nuevo Leon, Av. Pedro de Alba s/n, Cd. Universitaria, San Nicolás de los Garza, N.L., 66400, Mexico
Idalia Gomez
Affiliation:
Fac. de Ciencias Químicas, Universidad Autonoma de Nuevo Leon, Av. Pedro de Alba s/n, Cd. Universitaria, San Nicolás de los Garza, N.L., 66400, Mexico
Lucia Cantu
Affiliation:
Fac. de Ciencias Químicas, Universidad Autonoma de Nuevo Leon, Av. Pedro de Alba s/n, Cd. Universitaria, San Nicolás de los Garza, N.L., 66400, Mexico
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Abstract

In the present work, sol-gel method was used to incorporate in a ceramic material a non steroidal anti-inflammatory drug (piroxicam) as model drug. The incorporation of the drug in the SiO2 network was carried out at different sol-gel synthesis parameters, such as pH (3 and 5) and the alkoxide/water ratio (1:6 and 1:8). The biomaterial obtained was analyzed by thermal analysis TGA-DTA, infrared spectroscopy (FTIR), Scanning Electronic Microscopy (SEM) and X-ray diffraction (XRD); specific surface area and porosity were analyzed from nitrogen adsorption isotherm. Better drug incorporation into the material was achieved at the synthesis conditions of pH 5 and 1:6 alkoxide/water molar ratio.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1007: Symposium S – Organic/Inorganic Hybrid Materials-2007 , 2007 , 1007-S08-02
Copyright
Copyright © Materials Research Society 2007

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References

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