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Effect of DBD plasma on human cells in presence of osmolytes and denaturant

Published online by Cambridge University Press:  16 May 2012

Nagendra Kumar Kaushik ,
Pankaj Attri ,
Eun-Ha Choi  and
Neha Kaushik
Nagendra Kumar Kaushik
Affiliation:
Plasma Bioscience Research Center, Kwangwoon University, Seoul, South Korea 139-701
Pankaj Attri
Affiliation:
Department of Chemistry, University of Delhi, Delhi, INDIA 110007
Eun-Ha Choi
Affiliation:
Plasma Bioscience Research Center, Kwangwoon University, Seoul, South Korea 139-701
Neha Kaushik
Affiliation:
Plasma Bioscience Research Center, Kwangwoon University, Seoul, South Korea 139-701
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Abstract

Non thermal plasma is emerging as a novel tool for the treatment of living tissues for biological and medical purpose. In this study we described the effect of DBD (dielectric barrier discharge) plasma on both cancer and normal cell line in presence of osmolytes. Osmolytes having unique protective metabolic roles and also found in animal body, they are acting as antioxidants, providing redox balance, detoxifying sulfide, protect macromolecules, enhance protein folding and regulate cell volume. Based on these interesting properties of osmolytes, non thermal plasma in presence of osmolytes appears to provide a new outlook. Results of this study reveals that osmolytes in presence of plasma act as protecting agent for normal cells however, not to cancer cells in the presence of plasma. The main goal of this study is to protect normal cells from the toxic effect of DBD plasma.

Keywords

biologicalbiomedicaldevices
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1469: Symposium WW – Plasma Processing and Diagnostics for Life Sciences , 2012 , mrss12-1469-ww02-05
Copyright
Copyright © Materials Research Society 2012

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