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A Dual Constant Composition Study of the Kinetics of Mineralization and Demineralization of Bone Substitutes

Published online by Cambridge University Press:  15 February 2011

B.E. Tucker ,
G.L. Gorlinea ,
D.E. Carney ,
G.H. Nancollas  and
J.A. Bearcroft
B.E. Tucker
Affiliation:
State University of New York at Buffalo, Department of Chemistry, Buffalo, NY
G.L. Gorlinea
Affiliation:
State University of New York at Buffalo, Department of Chemistry, Buffalo, NY
D.E. Carney
Affiliation:
State University of New York at Buffalo, Department of Chemistry, Buffalo, NY
G.H. Nancollas
Affiliation:
State University of New York at Buffalo, Department of Chemistry, Buffalo, NY
J.A. Bearcroft
Affiliation:
Smith and Nephew Richards Inc., Memphis TN
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Abstract

Calcium phosphates are widely used as implantable materials in both dental andorthopaedic applications. Seven different bone substitutes (BS), including Interpore CorallineHAP, Cortical Bio-Oss, Endobon, Cancellous Bio-Oss, Dense HAP (hydroxyapatite), Collagraftgranules, and Porous HAP, have been evaluated using the Dual Constant Composition (DCC)kinetics methods. DCC measurements of the kinetics of dissolution and re-mineralization of theBS materials offer considerable advantages for the characterization of minor calcium-containingsurface species due to the insensitivity of conventional physical chemical methods such as X-raydiffraction and ESCA. Each sample was pre-conditioned (PC) in 0.15 M NaCl prior to the DCCkinetics procedures. The fastest dissolving material, Collagraft granules, showed a dissolution ratemore than two orders of magnitude larger than Dense HAP. Interestingly, the relativesupersaturation with respect to HAP (σ) following PC was normally negative, whereas withplasma sprayed HAP coated implants, these a values were as high as 20. Surface impurities mayplay a major role following in vivo implantation, since resorption is probably a major reparativemechanism. It is therefore essential to understand the dissolution behavior. Moreover, in a remineralizationmode, trace surface phases may determine the phase and morphology of the newlydeposited bone mineral.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 414: Symposium Z – Thin Films and Surfaces for Bioactivity and Biomedical Applications , 1995 , 71
Copyright
Copyright © Materials Research Society 1996

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