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Drug Delivery Systems Based on Hydroxyapaptite-coated Poly(lactic-co-glycolic acid) Microspheres

Published online by Cambridge University Press:  01 February 2011

Qingguo Xu
Affiliation:
[email protected], University of Oxford, Department of Materials, Parks Road, Oxford, OX1 3PH, United Kingdom, +44-1865-273714, +44-1865-273789
Jan T Czernuszka
Affiliation:
[email protected], University of Oxford, Department of Materials, Parks Road, Oxford, OX1 3PH, United Kingdom
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Abstract

Negatively charged poly(lactic-co-glycolic acid) (PLGA) microspheres were prepared by the solid-in-oil-in-water (s/o/w) method using the anionic surfactant, sodium dodecyl sulfate (SDS), and a hydrophilic antibiotic (amoxicillin) was encapsulated with an encapsulation efficiency of 40.6%. A layer of hydroxyapatite (HA) was coated on these negatively charged PLGA microspheres by a dual constant composition method in 3 - 6 hours. The HA-coated PLGA microspheres (HPLG) had a core-shell structure and were characterised by scanning electron microscopy, focused ion beam microscopy, energy-dispersive X-ray spectrometry, X-ray diffraction and Fourier transform infrared spectroscopy. Sustained release of amoxicillin from HPLG for at least 31 days was shown from in-vitro drug release experiments. A typical triphasic drug release profile had been observed for PLGA and HPLG microspheres. This device exhibited two desirable properties: the sustained release from PLGA and osteoconductivity from HA. Hence, it could have potential applications in delivering drugs to treat bone disorders or infections.

Type
Research Article
Copyright
Copyright © Materials Research Society 2008

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References

REFERENCES

[1] Joosten, U., Joist, A., Frebel, T., Brandt, B., Diederichs, S., Eiff, C. von, Biomaterials 25, 4287 (2004).Google Scholar
[2] Garvin, K., Feschuk, C., Clin. Orthop. Rel. Res. 437, 105 (2005).Google Scholar
[3] Matsumoto, T., Okazaki, M., Inoue, M., Yamaguchi, S., Kusunose, T., Toyonaga, T., Hamada, Y., Takahashi, J., Biomaterials 25, 3807 (2004).Google Scholar
[4] Stigter, M., Bezemer, J., Groot, K. de, Layrolle, P., J. Control. Release 99 (2004) 127137.Google Scholar
[5] Freiberg, S., Zhu, X., Int. J. Pharm. 282, 1 (2004).Google Scholar
[6] Sinha, V.R., Trehan, A., J. Control. Release 90, 261 (2003)-280.Google Scholar
[7] Lamprecht, A., Torres, H.R., Schafer, U., Lehr, C.M., J. Control. Release 69, 445 (2000).Google Scholar
[8] Xu, Q., Tanaka, Y., Czernuszka, J.T., Biomaterials 28 (2007) 26872694.Google Scholar
[9] Kawai, T., Ohtsuki, C., Kamitakahara, M., Miyazaki, T., Tanihara, M., Sakaguchi, Y., Konagaya, S., Biomaterials 25, 4529 (2004).Google Scholar
[10] Wong, A.T.C., Czernuszka, J.T., Colloid Surf. A-Physicochem. Eng. Asp. 78, 245 (1993).Google Scholar