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Density Functional Theory Calculations and Molecular Dynamics Simulations of the Interaction of Bio-molecules with Hydroxyapatite Surfaces in an Aqueous Environment

Published online by Cambridge University Press:  01 February 2011

Neyvis Almora-Barrios  and
Nora H de Leeuw
Neyvis Almora-Barrios
Affiliation:
[email protected], University College London, Chemistry, London, United Kingdom
Nora H de Leeuw
Affiliation:
[email protected], University College London, Chemistry, London, United Kingdom
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Abstract

In view of the importance of the hydroxyapatite/collagen composite of both natural bone tissue and synthetic biomaterials for hard tissue replacement, we have employed a combination of electronic structure calculations based on the Density Functional Theory and molecular dynamics simulations to investigate the adsorption of three major collagen I amino acids, as well as a complete peptide strand, at two hydroxyapatite surfaces, both in vacuo and in a liquid water environment. The free amino acids as well as the peptide form multiple interactions with the surfaces and bind more strongly to the (01.0) surface than the (0001) surface, in agreement with experiment, which has found that in natural bone the (01.0) surface grows preferentially from a collagen matrix.

Keywords

adsorptionbiomaterialbone
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1131: Symposium Y – Biomineral Interfaces–From Experiment to Theory , 2008 , 1131-Y01-06
Copyright
Copyright © Materials Research Society 2009

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