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Controlling the Sensing Volume of Metal Nanosphere Molecular Sensors

Published online by Cambridge University Press:  15 March 2011

Molly M. Miller  and
Anne A. Lazarides
Molly M. Miller
Affiliation:
Mechanical Engineering Materials Science, Duke University, Durham, NC, 27708
Anne A. Lazarides
Affiliation:
Mechanical Engineering Materials Science, Duke University, Durham, NC, 27708
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Noble metal nanoparticles and nanoshells support surface plasmons at optical frequencies. These resonances, known as localized surface plasmons (LSPs), are sensitive to the dielectric properties of the environment and, in particular, to the refractive index of the material close to the surface of the particle. This sensitivity can be exploited in molecular detection systems that use nanoparticles functionalized with receptors to (a) bind target molecules and (b) optically transduce the resulting change in the dielectric environment. Optimization of an optical nanoparticle sensor involves tailoring the particle to the target so as to maximize the sensitivity of spectroscopic features to the dielectric variation associated with binding of target molecules to the particle surface.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 820: Symposia O/R – Nanoengineered Assemblies and Advanced Micro/Nanosystems , 2004 , R6.5
Copyright
Copyright © Materials Research Society 2004

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