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Complex Material Using β-Cyclodextrins and Nickel-Zinc Ferrite to Obtain a Magnetically Targetable Drug Carrier

Published online by Cambridge University Press:  17 March 2011

Alberto Bocanegra ,
Nelcy D. S. Mohallem  and
Rubén D. Sinisterra
Alberto Bocanegra
Affiliation:
Universidade Federal de Minas Gerais, ICEx, Dept. of Chemistry, Avenida Antônio Carlos 6627, CEP 31270-901, Belo Horizonte, BRAZIL, [email protected]
Nelcy D. S. Mohallem
Affiliation:
Universidade Federal de Minas Gerais, ICEx, Dept. of Chemistry, Avenida Antônio Carlos 6627, CEP 31270-901, Belo Horizonte, BRAZIL, [email protected]
Rubén D. Sinisterra
Affiliation:
Universidade Federal de Minas Gerais, ICEx, Dept. of Chemistry, Avenida Antônio Carlos 6627, CEP 31270-901, Belo Horizonte, BRAZIL, [email protected]
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Abstract

In this study we describe the preparation and the characterization of a complex material using β-cyclodextrin covalently bound to Ni-Zn ferrite to obtain a magnetically targetable drug carrier. The physical-chemical characterization was performed through Fourier transformed infrared spectroscopy, X-ray diffraction, XRD, thermal analysis (TG/DTA), and atomic absorption spectroscopy. The results pointed out that β-cyclodextrin is externally covalently bound to Ni-Zn ferrite. However it was also verified that the β-cyclodextrin cavity is free and can include bioactive agents. The most interesting feature of this approach is the combination of magnetic properties and the host:guest technology to obtain an efficient targetable drug carrier system.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 711: Symposia FF/GG/HH – Advanced Biomaterials--Characterization, Tissue Engineering and Complexity , 2001 , HH3.30.1
Copyright
Copyright © Materials Research Society 2002

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References

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