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Combinatorial Compounding

Published online by Cambridge University Press:  26 February 2011

Nico Adams ,
Martin Moneke ,
Serguel Acikalin Guelmues ,
Dalil Chenouf ,
Matthias Rehahn  and
Ulrich S Schubert
Nico Adams
Affiliation:
[email protected], Eindhoven University of Technology, Laboratory of Macromolecular Chemistry and Nanoscience, P.O. Box 513, Eindhoven, N/A, 5600 MB, Netherlands, +31(0)402472125, +31(0)402474186
Martin Moneke
Affiliation:
[email protected], Deutsches Kunststoff Institut, Germany
Serguel Acikalin Guelmues
Affiliation:
[email protected], Deutsches Kunststoff Institut, Germany
Dalil Chenouf
Affiliation:
[email protected], Deutsches Kunststoff Institut, Germany
Matthias Rehahn
Affiliation:
[email protected], Deutsches Kunststoff Institut, Germany
Ulrich S Schubert
Affiliation:
[email protected], Eindhoven University of Technology, Laboratory of Macromolecular Chemistry and Nanoscience, Netherlands
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Abstract

The need for fast and low-cost processes for compound development is obvious when “bespoke” products are required in small quantities. In a typical development workflow, many experiments are needed for the systematic study of the effects of additives and their potential synergistic interactions. This is usually accomplished using the one-variable-at-a-time variational principle. However, if the complexity of the formulation is high, the number of experiments that needs to be conducted soon becomes prohibitive. Therefore, new, but potentially more effective additives are not easily introduced. To address this problem, the plastics processing industry is turning to the notion of combinatorics, which has been shown to accelerate R&D times both in the pharmaceutical industry as well as in other areas of materials science such as catalysis and polymer chemistry.

The contribution discusses the development of a combinatorial compounding line, consisting of a production-size twin screw extruder with four gravimetric feeding units for the addition of additives. Furthermore, the development of fast on-line and in-line analytics for compound characterization is discussed.

Keywords

combinatorial synthesisblendpolymer
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 894: Symposium LL – Combinatorial Methods and Informatics in Materials Science , 2005 , 0894-LL09-03
Copyright
Copyright © Materials Research Society 2006

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References

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