Hostname: page-component-78c5997874-t5tsf Total loading time: 0 Render date: 2024-11-03T05:37:50.512Z Has data issue: false hasContentIssue false
  • English
  • Français

Catechol-Bearing Polymeric Nanoparticles for Antioxidant Therapy

Published online by Cambridge University Press:  21 May 2015

Urara Hasegawa ,
Masaki Moriyama ,
Hiroshi Uyama ,
André J. van der Vlies ,
Stéphanie Metzger  and
Martin Ehrbar
Urara Hasegawa
Affiliation:
Frontier Research Base for Young Researchers, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan. Department of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.
Masaki Moriyama
Affiliation:
Department of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.
Hiroshi Uyama
Affiliation:
Department of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.
André J. van der Vlies
Affiliation:
Department of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan. Frontier Research Center, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.
Stéphanie Metzger
Affiliation:
Department of Obstetrics, University Hospital Zurich, Schmelzbergstrasse 12, 8091 Zürich, Switzerland.
Martin Ehrbar
Affiliation:
Department of Obstetrics, University Hospital Zurich, Schmelzbergstrasse 12, 8091 Zürich, Switzerland.
Get access

Abstract

Polymeric nanoparticles having redox-active catechol moieties, a common structural motif found in naturally-occurring antioxidants, were developed. We synthesized an amphiphilic catechol-bearing polymer that self-assembled to form nanoparticles with a diameter of 126 nm. The nanoparticles showed enhanced ROS-scavenging activity compared to the small catecholic compound dopamine. Furthermore, the nanoparticles inhibited ROS-mediated angiogenesis as shown by the endothelial cell tube formation assay and the chicken chorioallantoic membrane (CAM) assay.

Keywords

polymernanostructurebiomaterial
Type
Articles
Information
MRS Online Proceedings Library (OPL) , Volume 1797: Symposium KK – Nanomaterials in Translational Medicine , 2015 , mrss15-2132870
Copyright
Copyright © Materials Research Society 2015 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Dickinson, B.C. and Chang, C.J.. Nat. Chem. Biol. 7, 504–511 (2011).CrossRefGoogle Scholar
Ray, P.D., Huang, B.-W. and Tsuji, Y.. Cell. Signal. 24, 981–990 (2012).CrossRefGoogle Scholar
Trachootham, D., Alexandre, J. and Huang, P.. Nat. Rev. Drug Discov. 8, 579–591 (2009).CrossRefGoogle Scholar
Ushio-Fukai, M. and Nakamura, Y.. Cancer Lett. 266, 37–52 (2008).CrossRefGoogle Scholar
Moriyama, M., Metzger, S., van der Vlies, A.J., Uyama, H., Ehrbar, M., Hasegawa, U.. Adv. Healthc. Mater. 4(4), 569–575 (2015).CrossRefGoogle Scholar
Hasegawa, U., Moriyama, M., Uyama, H., van der Vlies, A.J.. Polymer. doi:10.1016/j.polymer.2015.03.080.CrossRefGoogle Scholar
Cao, G., Alessio, H.M., Cutler, R.G.. Free Radical Biology & Medicine. 14, 303–311 (1993).CrossRefGoogle Scholar
Niki, E.. Methods Enzymol. 186, 100–108 (1990).CrossRefGoogle Scholar