Hostname: page-component-cd9895bd7-dzt6s Total loading time: 0 Render date: 2024-12-27T01:45:15.238Z Has data issue: false hasContentIssue false
  • English
  • Français

Biomimetic Dextran Coatings On Silicon Wafers: Thin Film Properties And Wetting

Published online by Cambridge University Press:  11 February 2011

Michela Ombelli ,
David M. Eckmann  and
Russell J. Composto
Michela Ombelli
Affiliation:
Department of Chemistry, University of Perugia, Perugia, I-06123, Italy
David M. Eckmann
Affiliation:
Department of Anesthesia andThe Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA, 19104–4283, U.S.A.
Russell J. Composto
Affiliation:
Department of Materials Science and Engineering andCenter for Bioactive Materials and Tissue Engineering, University of Pennsylvania, Philadelphia, PA 19104–6272, U.S.A.
Get access

Abstract

There has been much recent interest in polysaccharide coatings for biotechnology applications. We obtained highly wettable dextran coatings applied to flat silicon wafer surfaces through a two-step process: in the first step, the silicon is aminated by the deposition of a self-assembled monolayer of 3-aminopropyltriethoxysilane (APTES); in the second step, polydisperse and low dispersity dextrans with molecular weights ranging from 1 kDa to 100 kDa are covalently grafted along the backbone to the surface amino groups to achieve strong interfacial anchoring. The effect of dextran concentration on film thickness and contact angle is investigated. Atomic force microscopy (AFM) has been employed to characterize surface roughness and coverage of the dextrans as well as the APTES monolayers. The synthetic surfaces were also tested for gas bubble adhesion properties.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 734: Symposia A/B – Defect-Mediated Phenomena in Ordered Polymers – Polymer/Metal Interfaces and Defect Mediated Phenomena in Ordered Polymers , 2002 , B10.7
Copyright
Copyright © Materials Research Society 2003

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

1. Henry, C.B.S. and Duling, B.R., Am J Physiol Heart Circ Physiol, 279, H2815 (2000).CrossRefGoogle Scholar
2. Österberg, E., Bergström, K., Holmberg, K., Riggs, J.A., Van Alstine, J.M., Schuman, T.P., Burns, N.L. and Harris, J.M., Coll. and Surf. A: Physicochemical and Engineering Aspects 77, 159–169 (1993).CrossRefGoogle Scholar
3. Dai, L., Zientek, P., John, H.A.W.St., Pasic, P., Chatelier, R.C. and Griesser, H.J., “Covalent surface attachment of polysaccharides via bifunctional epoxides”, Surface Modification of Polymeric Biomaterials, ed. Ratner, B.D. and Castner, D.G. (Plenum Press, 1996), pp.147156.Google Scholar
4. Holland, N.B., Qiu, Y., Ruegsegger, M. and Marchant, R.E., Nature 392, 799–801 (1998).CrossRefGoogle Scholar
5. Elender, G., Kühner, M. and Sackmann, E., Biosensors & Bioelectronics 11, 565–577 (1996).CrossRefGoogle Scholar
6. Elam, J.H., Nygren, H. and Stenberg, M., J. Biomed. Mater. Res., 18, 953 (1984).CrossRefGoogle Scholar
7. Massia, S.P., Stark, J. and Letbetter, D.S., Biomaterials, 21, 2253–2261 (2000).CrossRefGoogle Scholar
8. Österberg, E., Bergström, K., Holmberg, K., Schuman, T.P., Riggs, J.A., Burns, N.L., Van Alstine, J.M. and Harris, J.M., J. Biomed. Mater. Res. 29, 741–747 (1995).CrossRefGoogle Scholar
9. Cavanagh, D.P. and Eckmann, D.M., J. Fluid Mech. 398, 225–244 (1999).CrossRefGoogle Scholar