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Biocompatibility of Modified Polyetheretherketone (Peek-Wc) Membranes: Human Plasma Adsorption

Published online by Cambridge University Press:  11 February 2011

Loredana De Bartolo ,
Annarosa Gugliuzza ,
Beatrice Cirillo ,
Sabrina Morelli  and
Enrico Drioli
Loredana De Bartolo
Affiliation:
Research Institute on Membrane Technology, ITM-CNR, c/o University of Calabria, via P. Bucci cubo 17/C, 87030 Rende (CS) Italy- Tel: +39 0984 492010; Fax. +39 0984 402103 e-mail: [email protected]
Annarosa Gugliuzza
Affiliation:
Research Institute on Membrane Technology, ITM-CNR, c/o University of Calabria, via P. Bucci cubo 17/C, 87030 Rende (CS) Italy- Tel: +39 0984 492010; Fax. +39 0984 402103 e-mail: [email protected]
Beatrice Cirillo
Affiliation:
Research Institute on Membrane Technology, ITM-CNR, c/o University of Calabria, via P. Bucci cubo 17/C, 87030 Rende (CS) Italy- Tel: +39 0984 492010; Fax. +39 0984 402103 e-mail: [email protected]
Sabrina Morelli
Affiliation:
Research Institute on Membrane Technology, ITM-CNR, c/o University of Calabria, via P. Bucci cubo 17/C, 87030 Rende (CS) Italy- Tel: +39 0984 492010; Fax. +39 0984 402103 e-mail: [email protected]
Enrico Drioli
Affiliation:
Research Institute on Membrane Technology, ITM-CNR, c/o University of Calabria, via P. Bucci cubo 17/C, 87030 Rende (CS) Italy- Tel: +39 0984 492010; Fax. +39 0984 402103 e-mail: [email protected]
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Abstract

Polymeric membranes are widely used in biomedical field for bioartificial organs, medical devices and disposable clinical apparatus. Clinical utilization of blood-contacting devices requires the development of biomaterials with improved blood compatibility. The aim of this work was the exploration of a potential biocompatible membrane derived from a modified polyetheretherketone such as PEEK-WC. The surface affinity of this membrane to human plasma and plasmatic proteins such as albumin, fibrinogen and immunoglobulin G was compared to that of some commercial membranes. Changes with time of the membrane interfacial properties were evaluated by means of contact angle measurements using human protein solutions and human plasma. The extent of plasma protein adsorption on all investigated membranes was measured by comparing the behavior of the different polymer surfaces when contacting the three plasmatic proteins.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 752: Symposium AA – Membranes–Preparation, Properties and Applications , 2002 , AA14.2
Copyright
Copyright © Materials Research Society 2003

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References

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