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Amine-rich Polyelectrolyte Adhesion Layers as an Alternative to APTES for Surface Immobilization of Biomolecules and Nanostructures

Published online by Cambridge University Press:  30 August 2011

Stefan V. Stoianov ,
Jason I. Ridley  and
Hans D. Robinson
Stefan V. Stoianov
Affiliation:
Department of Physics, Virginia Tech, Blacksburg, VA 24061, U.S.A.
Jason I. Ridley
Affiliation:
Department of Physics, Virginia Tech, Blacksburg, VA 24061, U.S.A.
Hans D. Robinson
Affiliation:
Department of Physics, Virginia Tech, Blacksburg, VA 24061, U.S.A.
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Abstract

We propose the use of amine-rich polyelectrolyte multilayers as a versatile, high quality, tunable adhesive surfaces for biomedical and nanotechnological applications. The films are simple to fabricate under mild conditions and provide at least as good adhesion as standard aminopropyltriethoxysilane terminated glass substrates. In addition, the multilayer surface can be reliably passivated by acetylation with acetic anhydride which reduces the adhesion to the point that non-specific binding of proteins and nanoparticles becomes all but negligible. We demonstrate that this property, in combination with the robustness of the film, makes it possible to pattern the adhesiveness of the film at the nanoscale level.

Keywords

filmadhesionbiomedical
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1355: Symposium JJ – Biological Hybrid Materials for Life Sciences , 2011 , mrss11-1355-jj03-11
Copyright
Copyright © Materials Research Society 2011

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References

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