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Porphyrin-based nanocomposites for tumor photodynamic therapy

Published online by Cambridge University Press:  11 March 2019

Weitao Yang  and
Bingbo Zhang
Weitao Yang
Affiliation:
Institute of Photomedicine, Shanghai Skin Disease Hospital, The Institute for Biomedical Engineering and Nano Science, Tongji University School of Medicine, China; [email protected]
Bingbo Zhang
Affiliation:
Institute of Photomedicine, Shanghai Skin Disease Hospital, The Institute for Biomedical Engineering and Nano Science,Tongji University School of Medicine, China; [email protected]
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Abstract

Porphyrins and their associated derivatives have been widely used as photosensitizers for photodynamic therapy (PDT) of tumors. To overcome the limitations of porphyrin photosensitizers in PDT, the marriage of porphyrins and nanotechnology offers a new perspective to improve the efficacy and safety of porphyrin-based PDT. To date, various organic and inorganic nanoparticles have been developed for porphyrin delivery for high payload photosensitizers, protection from premature release of photosensitizers, and tumor-selective targeting. In this article, we summarize the strategies for porphyrin photosensitizer delivery, including encapsulation, covalent conjugation, self-assembly for PDT, and characterization methods of singlet oxygen (1O2) generation. We focus on the summarized strategies of improving cancer PDT efficacy by nanotechnology. Finally, the challenges and outlook for porphyrin-based nanocomposites-mediated PDT are discussed.

Keywords

nanostructurebiomedicallaser-induced reaction
Type
Self-Assembled Porphyrin and Macrocycle Derivatives
Information
MRS Bulletin , Volume 44 , Issue 3: Self-Assembled Porphyrin and Macrocycle Derivatives , March 2019 , pp. 189 - 194
Copyright
Copyright © Materials Research Society 2019 

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