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Materials that harness and modulate the immune system

Published online by Cambridge University Press:  10 January 2014

Jamal S. Lewis
Affiliation:
University of Florida, Gainesville; [email protected]
Krishnendu Roy
Affiliation:
University of Texas at Austin; [email protected]
Benjamin G. Keselowsky
Affiliation:
University of Florida; [email protected]
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Abstract

Recently, biomaterial scientists have married materials engineering and immunobiology to conceptualize new immunomodulatory materials. This special class of biomaterials can modulate and harness the innate properties of immune functionality for enhanced therapeutic efficacy. Generally, two fundamental strategies are followed in the design of immunomodulatory biomaterials: (1) immuno-evasive (immuno-mimetic, immuno-suppressing, or immuno-inert) biomaterials and (2) immuno-activating or immuno-enhancing biomaterials. This article highlights the development and application of a number of immunomodulatory materials, categorized by these two general approaches.

Type
Research Article
Copyright
Copyright © Materials Research Society 2014 

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