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The Impact of Biomaterials Research on Tissue Engineering

Published online by Cambridge University Press:  19 April 2013

Charles A. Vacanti
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Extract

The three most important components of tissue engineering are biomaterials, cellular biology, and vascular supply. Biomaterials are needed to control the delivery of new cells into the body. In the absence of biomaterials, cells that are injected into a vein, a cavity, or tissue tend to disperse, so a sufficiently high density of cells to perform the intended function—replacement or repair of a damaged structure—is never achieved.1 A porous delivery system is needed that confines the cells to the desired location and promotes their nourishment until blood vessels grow in and new tissue is formed. Biomaterials such as plastics can provide such a porous delivery system.

Type
Research Article
Information
MRS Bulletin , Volume 26 , Issue 10 , October 2001 , pp. 798 - 799
Copyright
Copyright © Materials Research Society 2001

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References

1. Langer, R. and Vacanti, J.P., Science 260 (1993) p. 920.CrossRefGoogle Scholar
2. Vacanti, C.A., Langer, R., Schloo, B., and Vacanti, J.P., Plast. Reconstr. Surg. 88 (5) (1991) p. 753.CrossRefGoogle Scholar
3. Atala, A., Cima, L.G., Kim, W., Paige, K.T., Vacanti, J.P., Retik, A.B., and Vacanti, C.A., J. Urol. 150 (1993) p. 745.CrossRefGoogle Scholar
4. Arevalo-Silva, C.A., Cao, Y., Weng, Y., Vacanti, M.P., Rodriguez, A., Vacanti, C.A., and Eavey, R.D., “The Effect of Fibroblast Growth Factor and Transforming Growth Factor-Beta on Porcine Chondrocytes and Tissue Engineered Autologous Elastic Cartilage,” Tissue Eng. in press.Google Scholar
5. Kim, W.S., Vacanti, C.A., Puelacher, W., Cima, L.G., Upton, J., Mooney, D., and Vacanti, J.P., “Cartilage Configured in Pre-Determined Geometric Shapes Employing Cell Transplantation on Prosthetic Artificial Biodegradable Synthetic Polymers,” presented at the Plastic Surgery Research Council Annual Meeting, Houston, TX, April 28-May 1, 1993.Google Scholar
6. Vacanti, C.A., Cima, L.G., Ratkowski, D., Upton, J., and Vacanti, J.P., in Tissue-Inducing Biomaterials, edited by Cima, L.G. and Ron, E.S. (Mater. Res. Soc. Symp. Proc. 252, Pittsburgh, 1992) p. 367.Google Scholar
7. Cao, Y., Vacanti, J.P., Paige, K.T., Upton, J., and Vacanti, C.A., Plast. Reconstr. Surg. 100 (2) (1997) p. 297 and p. 303.CrossRefGoogle Scholar
8. Puelacher, W.C., Vacanti, J.P., Ferraro, N.F., Schloo, B., and Vacanti, C.A., Int. J. Oral Maxillofac. Surg. 25 (3) (1996) p. 223.CrossRefGoogle Scholar
9. Vacanti, C.A., Bonassar, L.J., Vacanti, M.P., and Shufflebarger, J., New Engl. J. Med. 344 (20) (2001) p. 1511.CrossRefGoogle Scholar
10. Vacanti, M.P., Roy, A.K., Cortiella, J., Bonassar, L.J., and Vacanti, C.A., J. Cell. Biochem. 80 (3) (2001) p. 455.3.0.CO;2-Z>CrossRefGoogle Scholar
11. Vacanti, M.P., Leonard, J.L., Dore, B., Bonassar, L.J., Cao, Y., Stachelek, S.J., Vacanti, J.P., O'Connell, F., Chang, Y.S., Farwell, A.P., and Vacanti, C.A., “Tissue Engineered Spinal Cord,” presented at Symposium DD, Materials Research Society Meeting, San Francisco, April 24-28, 2000, Paper DD6.3.Google Scholar