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A DNA-Based Methodology for Preparing Nanocluster Circuits, Arrays, and Diagnostic Materials

Published online by Cambridge University Press:  17 June 2015

Chad A. Mirkin
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Extract

The following article is an edited transcript of the presentation given by Chad A. Mirkin (Northwestern University), recipient of the 1999 Outstanding Young Investigator award, at the 1999 Materials Research Society Spring Meeting on April 6 in San Francisco. Some examples of new work have been added to the transcript.

Our group has been developing a couple of projects over the past few years, both of which deal with the general area of nanotechnology. We are very excited about this work because we think it will lead to a general methodology for preparing nanostructured materials from common inorganic building blocks and readily available DNA-interconnect molecules. The intellectual payoff from this work will be a greater understanding of the collective interactions between nanoscale building blocks in the context of organized materials, while the technological payoffs range from the development of new and useful types of DNA detection strategies, to highperformance catalysts, to the realization of bioelectronic nanocircuitry.

The field of nanotechnology faces three main challenges. The first is to develop a combination of tools and materials that allows us to make small structures and control the architecture of large structures on the nanometer-length scale. Of course, we must be able to do this routinely before we can really explore this field in detail. The second important challenge is to determine the chemical and physical consequences of miniaturization, which is where the real science comes into play in nanotechnology.

Type
Technical Feature
Information
MRS Bulletin , Volume 25 , Issue 1: Aspects of Reconstructive Biomaterials , January 2000 , pp. 43 - 54
Copyright
Copyright © Materials Research Society 2000

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References

1. Mirkin, C.A., Letsinger, R.L., Mucic, R.C., and Storhoff, J.J., Nature 382 (1996) p. 607.CrossRefGoogle Scholar
2. Elghanian, R., Storhoff, J.J., Mucic, R.C., Letsinger, R.L., and Mirkin, C.A., Science 277 (1997) p. 1078.Google Scholar
3. Storhoff, J.J., Elghanian, R., Mucic, R.C., Mirkin, C.A., and Letsinger, R.L., J. Am. Chem. Soc. 120 (1998) p. 1959.Google Scholar
4. Mucic, R.C., Storhoff, J.J., Mirkin, C.A., and Letsinger, R.L., J. Am. Chem. Soc. 120 (1998) p. 12674.Google Scholar
5. Mitchell, G.P., Mirkin, C.A., and Letsinger, R.L., J. Am. Chem. Soc. 121 (1999) p. 8122.CrossRefGoogle Scholar
6. Storhoff, J.J., Mucic, R.C., and Mirkin, C.A., J. Cluster Science 8 (1997) p. 179.Google Scholar
7. Storhoff, J.J. and Mirkin, C.A., Chem. Rev. 99 (1999) p. 1849.CrossRefGoogle Scholar
8. Hayat, M.A., Colloidal Gold: Principles, Methods, and Applications (Academic Press: San Diego, 1991).Google Scholar
9. Creighton, J.A., Blatchford, C.G., and Albrecht, M.G., J. Chem. Soc. Faraday Trans. 275 (1979) p. 790.CrossRefGoogle Scholar
10. Henglein, A., Ershov, B.G., and Malow, M., J. Phys. Chem. 99 (1995) p. 14129.Google Scholar
11. Curtis, A.C., Duff, D.G., Edwards, P.P., Jefferson, D.A., Johnson, B.F.G., Kirkland, A.I., and Wallace, A.S., Angew. Chem. Intl. Ed. 27 (1988) p. 1530.Google Scholar
12. Murray, C.B., Norris, D.J., and Bawendi, M.G., J. Am. Chem. Soc. 115 (1993) p. 8706.Google Scholar
13. Chestoy, N., Hull, R., and Brus, L.E., J. Chem. Phys. 85 (1986) p. 2237.Google Scholar
14. Wang, Y. and Herron, N., J. Phys. Chem. 95 (1991) p. 525.CrossRefGoogle Scholar
15. Kavan, L., Gratzel, M., Rathousky, J., and Zukal, A., J. Electrochem. Soc. 143 (1996) p. 394.Google Scholar
16. Spanhel, L. and Anderson, M.A., J. Am. Chem. Soc. 113 (1991) p. 2826.CrossRefGoogle Scholar
17. Heath, J.R., Williams, R.S., Shiang, J.J., Wind, S.J., Chu, J., D'Emic, C., Chen, W., Stanis, C.L., and Bucchignano, J.J., J. Phys. Chem. 100 (1996) p. 3144.Google Scholar
18. Feltin, N. and Pileni, M.P., Langmuir 13 (1997) p. 3927.Google Scholar
19. Frens, G., Nature Physical Sciences 241 (1973) p. 20.Google Scholar
20. Grabar, K.C., Freeman, R.G., Hommer, M.B., and Natan, M.J., Anal. Chem. 67 (1995) p. 735.Google Scholar
21. Piner, R.D., Zhu, J., Xu, F., Hong, S., and Mirkin, C.A., Science 283 (1999) p. 661.Google Scholar
22. Piner, R.D. and Mirkin, C.A., Langmuir 13 (1997) p. 6864.CrossRefGoogle Scholar
23. Hong, S., Zhu, J., Mirkin, C.A., Science 286 (1999) p. 523.Google Scholar
24. Reprinted with permission from Nature 382 pp. 608–609. Copyright 1996, Macmillan Magazines Ltd.Google Scholar
25. Reprinted with permission from J. Am. Chem. Soc. 120 (1998) p. 12674.Google Scholar
26. Reprinted with permission from J. Am. Chem. Soc. 120 (1998) p. 1959.Google Scholar
27. Reprinted with permission from Science 277 (5329) p. 1079. Copyright 1997, American Association for the Advancement of Science.Google Scholar
28. Reprinted with permission from Science 283 (5402) p. 662. Copyright 1999, American Association for the Advancement of Science.Google Scholar
29. Reprinted with permission from Science 286 (5439) pp. 523–525. Copyright 1999, American Association for the Advancement of Science.Google Scholar