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Wound Healing Versus Regeneration: Role of the Tissue Environment in Regenerative Medicine

Published online by Cambridge University Press:  31 January 2011

Anthony Atala ,
Darrell J. Irvine ,
Marsha Moses  and
Sunil Shaunak
Anthony Atala
Affiliation:
Wake Forest University, Winston-Salem, NC 27157, USA; tel. 336-716-5701; and e-mail [email protected].
Darrell J. Irvine
Affiliation:
Department of Materials Science and Engineering, MIT, Cambridge, MA 02139, USA; e-mail [email protected].
Marsha Moses
Affiliation:
Harvard Medical School, Boston, MA 02115, USA; tel. 617-919-2207; and e-mail [email protected].
Sunil Shaunak
Affiliation:
Imperial College London, W12 0NN, UK; tel. 44-208-383-2301; and e-mail at [email protected].
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Abstract

One of the major challenges in the field of regenerative medicine is how to optimize tissue regeneration in the body by therapeutically manipulating its natural ability to form scar at the time of injury or disease. It is often the balance between tissue regeneration, a process that is activated at the onset of disease, and scar formation, which develops as a result of the disease process that determines the ability of the tissue or organ to be functional. Using biomaterials as scaffolds often can provide a “bridge” for normal tissue edges to regenerate over small distances, usually up to 1 cm. Larger tissue defect gaps typically require both scaffolds and cells for normal tissue regeneration to occur without scar formation. Various strategies can help to modulate the scar response and can potentially enhance tissue regeneration. Understanding the mechanistic basis of such multivariate interactions as the scar microenvironment, the immune system, extracellular matrix, and inflammatory cytokines may enable the design of tissue engineering and wound healing strategies that directly modulate the healing response in a manner favorable to regeneration.

Type
Research Article
Information
MRS Bulletin , Volume 35 , Issue 8: Engineering Materials for Regenerative Medicine , August 2010 , pp. 597 - 606
Copyright
Copyright © Materials Research Society 2010

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References

1.Stadelmann, W.K., Digenis, A.G., Tobin, G.R., Am. J. Surg. 176, 26S (1998).CrossRefGoogle Scholar
2.Quinn, J.V., Tissue Adhesives in Wound Care. (Decker, B.C., Hamilton, Ontario, 1998).Google Scholar
3.Midwood, K.S., Williams, L.V., Schwarzbauer, J.E., Int. J. Biochem. Cell Biol. 36, 1031 (2004).CrossRefGoogle Scholar
4.Chang, H.Y., Sneddon, J.B., Alizadeh, A.A., Sood, R., West, R.B., Montgomery, K., Chi, J.T., van de Rijn, M., Botstein, D., Brown, P.O., PLoS Biol. 2, E7 (2004).CrossRefGoogle Scholar
5.Garg, H.G., Longaker, M., Scarless Wound Healing (Marcel Dekker, New York, 2000).CrossRefGoogle Scholar
6.Dorin, R.P., Pohl, H.G., De Filippo, R.E., Yoo, J.J., Atala, A., World J. Urol. 26, 323 (2008).CrossRefGoogle Scholar
7.Yoo, J.J., Meng, J., Oberpenning, F., Atala, A., Urology 51, 221 (1998).CrossRefGoogle Scholar
8.Oberpenning, F., Meng, J., Yoo, J.J., Atala, A., Nat. Biotechnol. 17, 149 (1999).CrossRefGoogle Scholar
9.De Filippo, R.E., Bishop, C.E., Filho, L.F., Yoo, J.J., Atala, A., Transplantation 86, 208 (2008).CrossRefGoogle Scholar
10.Lee, D.J., Steen, J., Jordan, J.E., Kincaid, E.H., Kon, N.D., Atala, A., Berry, J., Yoo, J.J., Tissue Eng. Part A 15, 807 (2009).CrossRefGoogle Scholar
11.Chen, K.L., Eberli, D., Yoo, J.J., Atala, A., Proc. Natl. Acad. Sci. U.S.A. 107, 3346 (2010).CrossRefGoogle Scholar
12.Joraku, A., Sullivan, C.A., Yoo, J., Atala, A., Differentiation 75, 318 (2007).CrossRefGoogle Scholar
13.Stitzel, J., Liu, J., Lee, S.J., Komura, M., Berrya, J., Sokerc, S., Limc, G., Dykec, M.V., Richard, C., James, J.Y., Biomater. 27, 1088 (2006).CrossRefGoogle Scholar
14.Kim, B.S., Yoo, J.J., Atala, A., J. Biomed. Mater. Res. Part A 68, 201 (2004).CrossRefGoogle Scholar
15.Medzhitov, R., Nat. 454, 428 (2008).CrossRefGoogle Scholar
16.Bianchi, M.E., J. Leukocyte Biol. 81, 1 (2007).CrossRefGoogle Scholar
17.Anderson, J.M., Rodriguez, A., Chang, D.T., Semin. Immunol. 20, 86 (2008).CrossRefGoogle Scholar
18.Babensee, J.E., Semin. Immunol. 20, 101 (2008).CrossRefGoogle Scholar
19.Badylak, S.F., Gilbert, T.W., Semin. Immunol. 20, 109 (2008).CrossRefGoogle Scholar
20.Jones, J.A., Chang, D.T., Meyerson, H., Colton, E., Kwon, K., Matsuda, T., Anderson, M.M., J. Biomed. Mater. Res. Part A 83, 585 (2007).CrossRefGoogle Scholar
21.Guarda, G., Dostert, C., Staehli, F., Cabalzar, K., Castillo, R., Tardivel, A., Schneider, P., Tschopp, J., Nat. 460, 269 (2009).CrossRefGoogle Scholar
22.Serhan, C.N., Savill, J., Nat. Immunol. 6, 1191 (2005).CrossRefGoogle Scholar
23.Sozzani, S., Rusnati, M., Riboldi, E., Mitola, S., Presta, M., Trends Immunol. 28, 385 (2007).CrossRefGoogle Scholar
24.Mirza, R., DiPietro, L.A., Koh, T.J., Am. J. Pathol. 175, 2454 (2009).CrossRefGoogle Scholar
25.Chung, A.S., Waldeck, H., Schmidt, D.R., Kao, W.J., J. Biomed. Mater. Res. Part A 91, 742 (2009).CrossRefGoogle Scholar
26.Batten, P., Sarathchandra, P., Antoniw, J.W., Tay, S.S., Lowdell, M.W., Taylor, P.M., Yacoub, M.H., Tissue Eng. 12, 2263 (2006).CrossRefGoogle Scholar
27.Walsh, M.C., Kim, N., Kadono, Y., Rho, J., Lee, S.Y., Lorenzo, J., Choi, Y., Annu. Rev. Immunol. 24, 33 (2006).CrossRefGoogle Scholar
28.Paralkar, V.M., Borovecki, F., Ke, H.Z., Cameron, K.O., Lefker, B., Grasser, W.A., Owen, T.A., Li, M., DaSilva-Jardine, P., Zhou, M., Dunn, R.L., Dumount, F., Korsmeyer, R., Krasney, P., Brown, T.A., Plowchalk, D., Vukicevic, S., Thompson, D.D., Proc. Natl. Acad. Sci. U.S.A. 100, 6736 (2003).CrossRefGoogle Scholar
29.Gerstenfeld, L.C., Cho, T.-J., Kon, T., Aizawa, T., Tsay, A., Fitch, J., Barnes, G.L., Graves, D.T., Einhorn, T.A., J. Bone Miner. Res. 18, 1584 (2003).CrossRefGoogle Scholar
30.Yin, Y., Henzl, M.T., Lorber, B., Nakazawa, T., Thomas, T.T., Jiang, F., Langer, R., Benowitz, L.I., Nat. Neurosci. 9, 843 (2006).CrossRefGoogle Scholar
31.Lu, X., Richardson, P.M., J. Neurosci. 11, 972 (1991).CrossRefGoogle Scholar
32.Greco, S.J., Rameshwar, P., J. Immunol. 179, 3342 (2007).CrossRefGoogle Scholar
33.Michalopoulos, G.K., DeFrances, M.C., Science 276, 60 (1997).CrossRefGoogle Scholar
34.Andrades, J.A., Nimni, M.E., Becerra, J., Eisenstein, R., Davis, M., Sorgente, N., Exp. Cell Res. 227, 208 (1996).CrossRefGoogle Scholar
35.Del Rio-Tsonis, K., Tsonis, P.A., Zarkadis, I.K., Tsagas, A.G., Lambris, J.D., J. Immunol. 161, 6819 (1998).CrossRefGoogle Scholar
36.Mastellos, D., Papadimitriou, J.C., Franchini, S., Tsonis, P.A., Lambris, J.D., J. Immunol. 166, 2479 (2001).CrossRefGoogle Scholar
37.Chan, G., Mooney, D.J., Trends Biotechnol. 26, 382 (2008).CrossRefGoogle Scholar
38.Lumelsky, N.L., Tissue Eng. 13, 1393 (2007).CrossRefGoogle Scholar
39.Mountziaris, P.M., Mikos, A.G., Tissue Eng. Part B Rev. (Apr 30, 2008).Google Scholar
40.Harty, M., Neff, A.W., King, M.W., Mescher, A.L., Dev. Dyn. 226, 268 (2003).CrossRefGoogle Scholar
41.Richardson, T.P., Peters, M.C., Ennett, A.B., Mooney, D.J., Nat. Biotechnol. 19, 1029 (2001).CrossRefGoogle Scholar
42.Zisch, A.H., Lutolf, M.P., Ehrbar, M., Raeber, G.P., Rizzi, S.C., Davies, N., Schmökel, H., Bezuidenhout, D., Djonov, V., Zilla, P., Hubbell, J.A., FASEB J. 17, 2260 (2003).CrossRefGoogle Scholar
43.Lutolf, M.P., Hubbell, J.A., Nat. Biotechnol. 23, 47 (2005).CrossRefGoogle Scholar
44.Lauffenburger, D., Farrell, B., Tranquillo, R., Kistler, A., Zigmond, S., J. Cell Sci. 88 (Pt 4), 415 (1987).CrossRefGoogle Scholar
45.Zigmond, S.H., J. Cell. Biol. 75, 606 (1977).CrossRefGoogle Scholar
46.Kumamoto, T., Huang, E.K., Paek, H.J., Morita, A., Matsue, H., Valentini, R.F., Takashima, A., Nat. Biotechnol. 20, 64 (2002).CrossRefGoogle Scholar
47.Zhao, X., Jain, S., Benjamin Larman, H., Gonzalez, S., Irvine, D.J., Biomater. 26, 5048 (2005).CrossRefGoogle Scholar
48.Stachowiak, A.N., Irvine, D.J., J. Biomed. Mater. Res. Part A 85, 815 (2008).CrossRefGoogle Scholar
49.Ali, O.A., Huebsch, N., Cao, L., Dranoff, G., Mooney, D.J., Nat. Mater. 8, 151 (2009).CrossRefGoogle Scholar
50.Singh, A., Suri, S., Roy, K., Biomater. 30, 5187 (2009).CrossRefGoogle Scholar
51.Poznansky, M.C., Olszak, I.T., Foxall, R., Evans, R.H., Luster, A.D., Scadden, D.T., Nat. Med. 6, 543 (2000).CrossRefGoogle Scholar
52.Poznansky, M.C., Olszak, I.T., Evans, R.H., Wang, Z., Foxall, R.B., Olson, D.P., Weibrecht, K., Luster, A.D., Scadden, D.T., J. Clin. Invest. 109, 1101 (2002).CrossRefGoogle Scholar
53.Tharp, W.G., Yadav, R., Irimia, D., Upadhyaya, A., Samadani, A., Hurtado, O., Liu, S.-Y., Munisamy, S., Brainard, D.M., Mahon, M.J., Nourshargh, S., van Oudenaarden, A., Toner, M.G., Poznansky, M.C.. J. Leukocyte Biol. 79, 539 (2006).CrossRefGoogle Scholar
54.Christopherson, K.W. 2nd, Campbell, J.J., Travers, J.B., Hromas, R.A., J. Pharmacol. Exp. Ther. 302, 290 (2002).CrossRefGoogle Scholar
55.Perretti, M., Page, C.P., Gut 47, 14 (2000).CrossRefGoogle Scholar
56.Patel, D.D., Koopmann, W., Imai, T., Whichard, L.P., Yoshie, O., Krangel, M.S., Clin. Immunol. 99, 43 (2001).CrossRefGoogle Scholar
57.Proudfoot, A.E., Handel, T.M., Johnson, Z., Lau, E.K., Wang, P.L., Clark-Lewis, I., Borlat, F., Wells, T.N.C., Kosco-Vilbois, M.H., Proc. Natl. Acad. Sci. U.S.A. 100, 1885 (2003).CrossRefGoogle Scholar
58.Barouch, D.H., McKay, P.F., Sumida, S.M., Santra, S., Jackson, S.S., Gorgone, D.A., Lifton, M.A., Chakrabarti, B.K., Xu, L., Nabel, G.J., Letvin, N.L., J. Virol. 77, 8729 (2003).CrossRefGoogle Scholar
59.Song, R.J., Leong, K.W., Mol. Ther. 7, S257 (2003).Google Scholar
60.Haisch, A., Wanjura, F., Radke, C., Leder-Jöhrens, K., Gröger, A., Endres, M., Klaering, S., Loch, A., Sittinger, M., Eur. Arch. Otorhinolaryngol. 261, 216 (2004).CrossRefGoogle Scholar
61.Ho, M.L., Chang, J.K., Wang, G.J., Clin. Orthop. Relat. Res., 270 (1995).Google Scholar
62.Sharp, F.A., Ruane, D., Claass, B., Creagh, E., Harris, J., Malyala, P., Singh, M., O'Hagan, D.T., Pétrilli, V., Tschopp, J., O'Neill, L.A.J., Lavelle, E.C., Proc. Natl. Acad. Sci. U.S.A. 106, 870 (2009).CrossRefGoogle Scholar
63.Dostert, C., Pétrilli, V., Van Bruggen, R., Steele, C., Mossman, B.T., Tschopp, J., Science 320, 674 (2008).CrossRefGoogle Scholar
64.Hornung, V., Bauernfeind, F., Halle, A., Samstad, E.O., Kono, H., Rock, K.L., Fitzgerald, K.A., Latz, E., Nat. Immunol. 9, 847 (2008).CrossRefGoogle Scholar
65.Termeer, C., Benedix, F., Sleeman, J., Fieber, C., Voith, U., Ahrens, T., Miyake, K., Freudenberg, M., Galanos, C., Simon, J.C., J. Exp. Med. 195, 99 (2002).CrossRefGoogle Scholar
66.Da Silva, C.A., Chalouni, C., Williams, A., Hartl, D., Lee, C.G., Elias, J.A., J. Immunol. 182, 3573 (2009).CrossRefGoogle Scholar
67.Yang, D., Jones, K.S., J. Biomed. Mater. Res. Part A 90, 411 (2009).CrossRefGoogle Scholar
68.Tam, S.K., Dusseault, J., Polizu, S., Menard, M., Halle, J.P., Yahia, L., Biomater. 27, 1296 (2006).CrossRefGoogle Scholar
69.Klock, G., Pfeffermann, A., Ryser, C., Grohn, P., Kuttler, B., Hahn, J.J., Zimmermann, U., Biomater. 18, 707 (1997).CrossRefGoogle Scholar
70.Pieper, J.S., Van Wachem, P.B., Van Luyn, M.J.A., Brouwer, L.A., Hafmans, T., Veerkamp, J.H., Van Kuppevelt, T.H., Biomater. 21, 1689 (2000).CrossRefGoogle Scholar
71.Sterling, H., Saginario, C., Vignery, A., J. Cell Biol. 143, 837 (1998).CrossRefGoogle Scholar
72.Yoon, S.J., Kim, S.H., Ha, H.J., Ko, Y.K., So, J.W., Kim, M.S., Yang, Y., Khang, G., Rhee, J.M., Lee, H.B., Tissue Eng. Part A 14, 539 (2008).CrossRefGoogle Scholar
73.van Putten, S.M., Wubben, M., Hennink, W.E., van Luyn, M.J., Harmsen, M.C., Biomater. 30, 730 (2009).CrossRefGoogle Scholar
74.Reddy, S.T., van der Vlies, A.J., Simeoni, E., Angeli, V., Randolph, G.J., O'Neil, C.P., Lee, L.K., Swartz, M.A., Hubbell, J.A., Nat. Biotechnol. 25, 1159 (2007).CrossRefGoogle Scholar
75.Rothenfluh, D.A., Bermudez, H., O'Neil, C.P., Hubbell, J.A., Nat. Mater. 7, 248 (2008).CrossRefGoogle Scholar
76.Roy, R., Zhang, B., Moses, M.A., Exp. Cell Res. 312, 608 (2006).CrossRefGoogle Scholar
77.Matrisian, L.M., Trends Genet. 6, 121 (1990).CrossRefGoogle Scholar
78.Nagase, H., Woessner, J.F. Jr., J. Biol. Chem. 274, 21491 (1999).CrossRefGoogle Scholar
79.Bode, W., Biochem. Soc. Symp. 1 (2003).Google Scholar
80.Visse, R., Nagase, H., Circ. Res. 92, 827 (2003).CrossRefGoogle Scholar
81.Woessner, J.F. Jr., Nagase, H., Matrix Metalloproteinases and TIMPs (Oxford University Press, New York, 2000).CrossRefGoogle Scholar
82.Bode, W., Maskos, K., Methods Mol. Biol. 151, 45 (2001).Google Scholar
83.Buckley-Sturrock, A., Woodward, S.C., Senior, R.M., Griffin, G.L., Klagsbrun, M., Davidson, J.M., J. Cell Physiol. 138, 70 (1989).CrossRefGoogle Scholar
84.Neely, A.N., Clendening, C.E., Gardner, J., Greenhalgh, D.G., Warden, G.D., Wound Repair Regen. 7, 166 (1999).CrossRefGoogle Scholar
85.Shapiro, S.D., Kobayashi, D.K., Welgus, H.G., J. Biol. Chem. 267, 13890 (1992).CrossRefGoogle Scholar
86.Stock, U.A., Wiederschain, D., Kilroy, S.M., Shum-Tim, D., Khalil, P.N., Vacanti, J.P., Mayer, J.E., Moses, M.A., J. Cell Biochem. 81, 220 (2001).3.0.CO;2-O>CrossRefGoogle Scholar
87.Karim, M.A., Ferguson, A.G., Wakim, B.T., Samarel, A.M., Am. J. Physiol. 260, C316 (1991).CrossRefGoogle Scholar
88.Peters, C.A., Freeman, M.R., Fernandez, C.A., Shepard, J., Wiederschain, D.G., Moses, M.A., Am. J. Physiol. 272, R1960 (1997).Google Scholar
89.Wysocki, A.B., Staiano-Coico, L., Grinnell, F., J. Invest. Dermatol. 101, 64 (1993).CrossRefGoogle Scholar
90.Wysocki, A.B., Staiano-Coico, L., Grinnell, F., J. Cell Biol. 115, 137a (1993).Google Scholar
91.Moses, M.A., Harper, J., Cancer: Cell Structures, Carcinogens and Tumor Pathogenesis, EXS 96, 223 (2005).Google Scholar
92.Greene, A.K., Puder, M., Roy, R., Kilroy, S., Louis, G., Folkman, J., Moses, M.A., Transplant. 78, 1139 (2004).CrossRefGoogle Scholar
93.Alwayn, I.P., Verbesey, J.E., Kim, S., Roy, R., Arsenault, D.A., Greene, A.K., Novak, K., Laforme, A., Lee, S., Moses, M.A., Puder, M., J. Surg. Res. 145, 192 (2008).CrossRefGoogle Scholar
94.Bellayr, I., Mu, X., Li, Y., Future Med. Chem. 1, 1095 (2009).CrossRefGoogle Scholar
95.Moses, M.A., Marikovsky, M., Harper, J.W., Vogt, P., Eriksson, E., Klagsbrun, M., Langer, R., J. Cell Biochem. 60, 379 (1996).3.0.CO;2-T>CrossRefGoogle Scholar
96.Reiss, M.J., Han, Y.P., Garcia, E., Goldberg, M., Yu, H., Garner, W.L., Surgery 147, 295 (2010).CrossRefGoogle Scholar
97.Grinnell, F., Ho, C.H., Wysocki, A., J. Invest. Dermatol. 98, 410 (1992).CrossRefGoogle Scholar
98.Saarialho-Kere, U.K., Chang, E.S., Welgus, H.G., Parks, W.C., J. Clin. Invest. 90, 1952 (1992).CrossRefGoogle Scholar
99.Hennessey, P.J., Black, C.T., Andrassy, R.J., Arch. Surg. 125, 926 (1990).CrossRefGoogle Scholar
100.Hasebe, T., Harasawa, S., Miwa, T., Shibata, T., Inayama, S., Tokai J. Exp. Clin. Med. 12, 147 (1987).Google Scholar
101.Zuany-Amorim, C., Hastewell, J., Walker, C., Nat. Rev. Drug Discov. 1, 797 (2002).CrossRefGoogle Scholar
102.Ohto, U., Fukase, K., Miyake, K., Satow, Y., Science 316, 1632 (2007).CrossRefGoogle Scholar
103.Park, B.S., Song, D.H., Kim, H.M., Choi, B.-S., Lee, H., Lee, J.-O., Nature 458, 1191 (2009).CrossRefGoogle Scholar
104.Kim, H.M., Park, B.S., Kim, J.I., Kim, S.E., Lee, J., Oh, S.C., Enkhbayar, P., Matsushima, N., Lee, H., Yoo, O.J., Cell 130, 906 (2007).CrossRefGoogle ScholarPubMed
105.Kagan, J.C., Su, T., Horng, T., Chow, A., Akira, S., Medzhitov, R., Nat. Immunol. 9, 361 (2008).CrossRefGoogle Scholar
106.Boros, P., Bromberg, J.S., Am. J. Transplant. 6, 652 (2006).CrossRefGoogle Scholar
107.Jiang, D., Liang, J., Fan, J., Yu, S., Chen, S., Luo, Y., Prestwich, G.D., Mascarenhas, M.M., Garg, H.G., Quinn, D.A., Nat. Med. 11, 1173 (2005).CrossRefGoogle Scholar
108.Scheibner, K.A., Lutz, M.A., Boodoo, S., Fenton, M.J., Powell, J.D., Horton, M.R., J. Immunol. 177, 1272 (2006).CrossRefGoogle Scholar
109.Benhamron, S., Nechushtan, H., Verbovetski, I., Krispin, A., Abboud-Jarrous, G., Zcharia, E., Edovitsky, E., Nahari, E., Peretz, T., Vlodavsky, I., Mevorach, D., J. Immunol. 176, 6417 (2006).CrossRefGoogle Scholar
110.Tesar, B.M., Jiang, D., Liang, J., Palmer, S.M., Noble, P.W., Am. J. Transplant. 6, 2622 (2006).CrossRefGoogle Scholar
111.Takahashi, Y., Li, L., Kamiryo, M., Asteriou, T., Moustakas, A., Yamashita, H., Heldin, P., J. Biol. Chem. 280, 24195 (2005).CrossRefGoogle Scholar
112.Miller, S.I., Ernst, R.K., Bader, M.W., Nat. Rev. Microbiol. 3, 36 (2005).CrossRefGoogle Scholar
113.Parish, C.R., Nat. Rev. Immunol. 6, 633 (2006).CrossRefGoogle Scholar
114.Flo, T.H., Ryan, L., Latz, E., Takeuchi, O., Monks, B.G., Lien, E., Halaas, O., Akira, S., J. Biol. Chem. 277, 35489 (2002).CrossRefGoogle Scholar
115.Svenson, S., Tomalia, D.A., Adv. Drug Deliv. Rev. 57, 2106 (2005).CrossRefGoogle Scholar
116.Dear, J.W., Hisataka, K., Jo, S.-K., Holly, M.K., Hu, X., Yuen, P.S.T., Brechbiel, M.W., Star, R.A., Kidney Int. 67, 2159 (2005).CrossRefGoogle Scholar
117.Shaunak, S., Thomas, S., Gianasi, E., Godwin, A., Jones, E., Nat. Biotechnol. 22, 977 (2004).CrossRefGoogle Scholar