Hostname: page-component-78c5997874-xbtfd Total loading time: 0 Render date: 2024-11-05T13:32:00.243Z Has data issue: false hasContentIssue false
  • English
  • Français

Polymeric Controlled Nucleic Acid Delivery

Published online by Cambridge University Press:  31 January 2011

Kam W. Leong
Get access

Abstract

Gene therapy harbors great promise for the treatment of a variety of inherited and acquired diseases, but its potential can be realized only with safe and effective carriers. Although viruses can efficiently transfer foreign genes to cells, their long-term safety remains a concern. Polymers can serve as a carrier to facilitate gene transfer, either by condensing DNA to the size of nanoparticles that can be internalized by cells, or by entrapping DNA in matrices or micro/nanoparticles for sustained release. However, polymeric controlled gene delivery remains highly inefficient. This review covers the major barriers for nonviral gene transfer and briefly describes the different types of polymers developed to overcome these barriers. With the tremendous promise of genetic medicine, nonviral gene delivery is a worthy goal for biomaterials and nanotechnology research.

Keywords

biomedical materialsgene deliverynanoparticlesnucleic acid deliverypolymeric
Type
Research Article
Information
MRS Bulletin , Volume 30 , Issue 9: Designer Materials for Nucleic Acid Delivery , September 2005 , pp. 640 - 646
Copyright
Copyright © Materials Research Society 2005

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1.Schiavone, N., Donnini, M., Nicolin, A., and Capaccioli, S., Curr. Pharm. Des. 10 (7) (2004) p. 769CrossRefGoogle Scholar
2.Dillon, C.P., Sandy, P., Nencioni, A., and Kissler, S., Annu. Rev. Physiol. 67 (2005) p. 147CrossRefGoogle Scholar
3.Kaiser, J., Science 304 (2004) p. 1423CrossRefGoogle ScholarPubMed
4.Williams, D.A. and Baum, C., Science 302 (2003) p. 400CrossRefGoogle Scholar
5.Cavazzana-Calvo, M., Thrasher, A., and Mavilio, F., Nature 427 (2004) p. 779CrossRefGoogle Scholar
6.Fratantoni, J.C., Dzekunov, S., Singh, V., and Liu, L.N., Cytotherapy 5 (3) (2003) p. 208CrossRefGoogle Scholar
7.Benns, J.M., Maheshwari, A., Furgeson, D.Y., Mahato, R.I., and Kim, S.W., J. Drug Target 9 (2) (2001) p. 123CrossRefGoogle Scholar
8.Nishikawa, M. and Huang, L., Hum. Gene Ther. 12 (8) (2001) p. 861CrossRefGoogle Scholar
9.Pun, S.H. and Davis, M.E., Bioconjugate Chem. 13 (3) (2003) p. 630CrossRefGoogle Scholar
10.Thomas, M. and Klibanov, A.M., Appl. Microbiol. Biotechnol. 62 (1) (2003) p. 27CrossRefGoogle Scholar
11.Panyam, J. and Labhasetwar, V., Adv. Drug Deliv. Rev. 55 (3) (2003) p. 329CrossRefGoogle Scholar
12.Ahn, C.H., Chae, S.Y., Bae, T.H., and Kim, S.W., J. Controlled Release 80 (1–3) (2002) p. 273CrossRefGoogle Scholar
13.Blessing, T., Kursa, M., Holzhauser, R., Kircheis, R., and Wagner, E., Bioconjugate Chem. 12 (4) (2001) p. 529CrossRefGoogle Scholar
14.Brownlie, A., Uchegbu, I.F., and Schatzlein, A.G., Int. J. Pharm. 274 (1–2) (2004) p. 41CrossRefGoogle Scholar
15.Gautam, A., Waldrep, J.C., Orson, F.M., Kinsey, B.M., Xu, B., and Densmore, C.L., Methods Mol. Med. 75 (2003) p. 561Google Scholar
16.Kunath, K., von Harpe, A., Fischer, D., and Kissel, T., J. Controlled Release 88 (1) (2003) p. 159CrossRefGoogle Scholar
17.Merdan, T., Callahan, J., Petersen, H., Kunath, K., Bakowsky, U., Kopeckova, P., Kissel, T., and Kopecek, J., Bioconjugate Chem. 14 (5) (2003) p. 989CrossRefGoogle Scholar
18.Lampela, P., Soininen, P., Urtti, A., Mannisto, P.T., and Raasmaja, A., Int. J. Pharm. 270 (1–2) (2004) p. 175CrossRefGoogle Scholar
19.Forrest, M.L., Koerber, J.T., and Pack, D.W., Bioconjugate Chem. 14 (5) (2003) p. 934CrossRefGoogle Scholar
20.Forrest, M.L., Meister, G.E., Koerber, J.T., and Pack, D.W., Pharm. Res. 21 (2) (2004) p. 365CrossRefGoogle Scholar
21.Wightman, L., Kircheis, R., Rossler, V., Carotta, S., Ruzicka, R., Kursa, M., and Wagner, E., J. Gene Med. 3 (4) (2001) p. 362CrossRefGoogle Scholar
22.Zou, S.M., Erbacher, P., Remy, J.S., and Behr, J.P., J. Gene Med. 2 (2) (2000) p. 1283.0.CO;2-W>CrossRefGoogle Scholar
23.Brissault, B., Kichler, A., Guis, C., Leborgne, C., Danos, O., and Cheradame, H., Bioconjugate Chem. 14 (3) (2003) p. 581CrossRefGoogle Scholar
24.Gosselin, M.A., Guo, W., and Lee, R.J., Bioconjugate Chem. 12 (6) (2001) p. 989CrossRefGoogle Scholar
25.Ahn, C.H., Chae, S.Y., Bae, Y.H., and Kim, S.W., J. Controlled Release 97 (3) (2004) p. 567Google Scholar
26.Oupicky, D., Carlisle, R.C., and Seymour, L.W., Gene Ther. 8 (9) (2001) p. 713CrossRefGoogle Scholar
27.Putnam, D., Gentry, C.A., Pack, D.W., and Langer, R., Proc. Natl. Acad. Sci. USA 98 (3) (2001) p. 1200CrossRefGoogle Scholar
28.Janat-Amsbury, M.M., Yockman, J.W., Lee, M., Kern, S., Furgeson, D.Y., Bikram, M., and Kim, S.W., Mol Ther. 9 (6) (2004) p. 829CrossRefGoogle Scholar
29.Kim, T.G., Kang, S.Y., Kang, J.H., Cho, M.Y., Kim, J.I., Kim, S.H., and Kim, J.S., Bioconjugate Chem. 15 (2) (2004) p. 326CrossRefGoogle Scholar
30.Lee, J.S., Lee, M., and Kim, S.W., Pharm. Res. 21 (7) (2004) p. 1229CrossRefGoogle Scholar
31.Jeong, J.H., Byun, Y., and Park, T.G., J. Biomater. Sci. Polym. Ed. 14 (1) (2003) p. 1CrossRefGoogle Scholar
32.Jeong, J.H., Kim, S.W., and Park, T.G., Bioconjugate Chem. 14 (2) (2003) p. 473CrossRefGoogle Scholar
33.Lim, Y.B., Han, S.O., Kong, H.U., Lee, Y., Park, J.S., Jeong, B., and Kim, S.W., Pharm. Res. 17 (7) (2000) p. 811CrossRefGoogle Scholar
34.Maheshwari, A., Han, S., Mahato, R.I., and Kim, S.W., Gene Ther. 9 (16) (2002) p. 1075CrossRefGoogle Scholar
35.Lee, M., Ko, K.S., Oh, S., and Kim, S.W., J. Controlled Release 88 (2) (2003) p. 333CrossRefGoogle Scholar
36.Kramer, M., Stumbe, J.F., Grimm, G., Kaufmann, B., Kruger, U., Weber, M., and Haag, R., ChemBioChem 5 (8) (2004) p. 1081CrossRefGoogle Scholar
37.Jones, N.A., Hill, I.R., Stolnik, S., Bignotti, F., Davis, S.S., and Garnett, M.C., Biochim. Biophys. Acta 1517 (1) (2000) p. 1CrossRefGoogle Scholar
38.Zhang, Z.Y. and Smith, B.D., Bioconjugate Chem. 11 (6) (2000) p. 805CrossRefGoogle Scholar
39.Lee, J.H., Lim, Y.B., Choi, J.S., Lee, Y., Kim, T.I., Kim, H.J., Yoon, J.K., Kim, K., and Park, J.S., Bioconjugate Chem. 14 (6) (2003) p. 1214CrossRefGoogle Scholar
40.Lim, D.W., Yeom, Y.I., and Park, T.G., Bioconjugate Chem. 11 (5) (2000) p. 688CrossRefGoogle Scholar
41.Anderson, D.G., Lynn, D.M., and Langer, R., Angew. Chem. Int. Ed. Engl. 42 (27) (2003) p. 3153CrossRefGoogle Scholar
42.Jon, S., Anderson, D.G., and Langer, R., Biomacromolecules 4 (6) (2003) p. 1759CrossRefGoogle Scholar
43.Luten, J., van Steenis, J.H., van Someren, R., Kemmink, J., Schuurmans-Nieuwenbroek, N.M., Koning, G.A., Crommelin, D.J., van Nostrum, C.F., and Hennink, W.E., J. Controlled Release 89 (3) (2003) p. 483CrossRefGoogle Scholar
44.Bellocq, N.C., Pun, S.H., Jensen, G.S., and Davis, M.E., Bioconjugate Chem. 14 (6) (2003) p. 1122CrossRefGoogle Scholar
45.Hwang, S.J., Bellocq, N.C., and Davis, M.E., Bioconjugate Chem. 12 (2) (2001) p. 280CrossRefGoogle Scholar
46.Popielarski, S.R., Mishra, S., and Davis, M.E., Bioconjugate Chem. 14 (3) (2003) p. 672CrossRefGoogle Scholar
47.Davis, M.E., Pun, S.H., Bellocq, N.C., Reineke, T.M., Popielarski, S.R., Mishra, S., and Heidel, J.D., Curr Med. Chem. 11 (2) (2004) p. 179CrossRefGoogle Scholar
48.Pun, S.H., Bellocq, N.C., Liu, A., Jensen, G., Machemer, T., Quijano, E., Schluep, T., Wen, S., Engler, H., Heidel, J., and Davis, M.E., Bioconjugate Chem. 15 (4) (2004) p. 831CrossRefGoogle Scholar
49.Reineke, T.M. and Davis, M.E., Bioconjugate Chem. 14 (1) (2003) p. 255CrossRefGoogle Scholar
50.Reineke, T.M. and Davis, M.E., Bioconjugate Chem. 14 (1) (2003) p. 247CrossRefGoogle Scholar
51.Mishra, S.P., Webster, P., and Davis, M.E., Eur. J. Cell Biol. 83 (3) (2004) p. 97CrossRefGoogle Scholar
52.Wen, J., Mao, H.Q., Li, W.P., Lin, K.Y., and Leong, K.W., J. Pharm. Sci. 93 (8) (2004) p. 2142CrossRefGoogle Scholar
53.Zhao, Z., Wang, J., Mao, H.Q., and Leong, K.W., Adv. Drug Delivery Rev. 55 (4) (2003) p. 483CrossRefGoogle Scholar
54.Wang, J., Zhang, P.C., Mao, H.Q., and Leong, K.W., Gene Ther. 9 (18) (2002) p. 1254CrossRefGoogle Scholar
55.Wang, J., Huang, S.W., Zhang, P.C., Mao, H.Q., and Leong, K.W., Int. J. Pharm. 265 (1–2) (2003) p. 75CrossRefGoogle Scholar
56.Huang, S.W., Wang, J., Zhang, P.C., Mao, H.Q., Zhuo, R.X., and Leong, K.W., Biomacromolecules 5 (2) (2004) p. 306CrossRefGoogle Scholar
57.Wang, J., Mao, H.Q., and Leong, K.W., J. Am. Chem. Soc. 123 (38) (2001) p. 9480CrossRefGoogle Scholar
58.Li, Y., Wang, J., Lee, C.G.L., Wang, C.Y., Gao, S.J., Tang, G.P., Ma, Y.X., Yu, H., Mao, H.Q., Leong, K.W., and Wang, S., Gene Ther. 11 (1) (2004) p. 109CrossRefGoogle Scholar
59.Wang, J., Zhang, P.C., Lu, H.F., Ma, N., Wang, S., Mao, H.Q., and Leong, K.W., J. Controlled Release 83 (1) (2002) p. 157CrossRefGoogle Scholar
60.Wang, X.L., Zhang, P.C., Dai, H., Leong, K.W., and Mao, H.Q., presented at 29th Int. Symp. Controlled Release of Bioactive Materials, Seoul, Korea (2002)Google Scholar
61.Wang, J., Gao, S.J., Zhang, P.C., Wang, S., Mao, M.Q., and Leong, K.W., Gene Ther. 11 (12) (2004) p. 1001CrossRefGoogle Scholar
62.Zhang, P.C., Wang, J., Leong, K.W., and Mao, H.Q., Biomacromolecules 6 (1) (2005) p. 54CrossRefGoogle Scholar
63.Zhang, X.Q., Wang, X.L., Zhang, P.C., Liu, Z.L., Zhuo, R.X., Mao, H.Q., and Leong, K.W., J. Controlled Release 102 (3) (2005) p. 749CrossRefGoogle Scholar
64.Kabanov, A.V., Batrakova, E.V., and Alakhov, V.Y., J. Controlled Release 82 (2–3) (2002) p. 189CrossRefGoogle Scholar
65.Kabanov, A.V., Batrakova, E.V., Sriadlbhatla, S., Yang, Z.H., Kelly, D.L., and Alakov, V.Y., J. Controlled Release 101 (1–3) (2005) p. 259CrossRefGoogle Scholar
66.Cohen, H., Levy, R.J., Gao, J., Fishbein, I., Kousaev, V., Sosnowski, S., Slomkowski, S., and Golomb, G., Gene Ther. 7 (22) (2000) p. 1896CrossRefGoogle Scholar
67.Fang, N., Chan, V., Mao, H.Q., and Leong, K.W., Biomacromolecules 2 (4) (2001) p. 1161CrossRefGoogle Scholar
68.Mao, H.Q., Roy, K., Troung-Le, V.L., Janes, K.A., Lin, K.Y., Wang, Y., August, J.T., and Leong, K.W., J. Controlled Release 70 (3) (2001) p. 399CrossRefGoogle Scholar
69.Leong, K.W., Mao, H.Q., Truong-Le, V.L., Roy, K., Walsh, S.M., and August, J.T., J. Controlled Release 53 (1–3) (1998) p. 183CrossRefGoogle Scholar
70.Truong-Le, V.L., August, J.T., and Leong, K.W., Hum. Gene Ther. 9 (12) (1998) p. 1709CrossRefGoogle Scholar
71.Roy, K., Mao, H.Q., Huang, S.K., and Leong, K.W., Nat. Med. 5 (4) (1999) p. 387CrossRefGoogle Scholar
72.MacLaughlin, F.C., Mumper, R.J., Wang, J.J., Tagliaferri, J.M., Gill, I., Hinchcliffe, M., and Rolland, A.P., J. Controlled Release 56 (1–3) (1998) p. 259CrossRefGoogle Scholar
73.Lee, K.Y., Kwon, I.C., Kim, Y.H., Jo, W.H., and Jeong, S.Y., J. Controlled Release 51 (2–3) (1998) p. 213CrossRefGoogle Scholar
74.Richardson, S.C., Kolbe, H.V., and Duncan, R., Int. J. Pharm. 178 (2) (1999) p. 231CrossRefGoogle Scholar
75.Thanou, M., Verhoef, J.C., and Junginger, H.E., Adv. Drug Deliv. Rev. 50 (Suppl. 1) (2001) p. S91.CrossRefGoogle Scholar
76.Kiang, T., Wen, J., Lim, H.W., and Leong, K.W., Biomaterials 25 (22) (2004) p. 5293CrossRefGoogle Scholar
77.Truong-Le, V.L., Walsh, S.M., Schweibert, E., Mao, H.Q., Guggino, W.B., August, J.T., and Leong, K.W., Arch. Biochem. Biophys 361 (1) (1999) p. 47CrossRefGoogle Scholar
78.Wang, J., Lee, I.L., Lim, W.S., Chia, S.M., Yu, H., Leong, K.W., and Mao, H.Q., Int. J. Pharm. 279 (1–2) (2004) p. 115CrossRefGoogle Scholar
79.Bottcher, C., Endisch, C., Fuhrhop, J.H., Catterall, C., and Eaton, M., J. Am. Chem. Soc. 120 (1) (1998) p. 12CrossRefGoogle Scholar
80.Hud, N.V., Downing, K.H., and Balhorn, R., in Proc. Natl. Acad. Sci. USA 92 (8) (1995) p. 3581CrossRefGoogle Scholar
81.Golan, R., Pietrasanta, L.I., Hsieh, W., and Hansma, H.G., Biochemistry 38 (42) (1999) p. 14069CrossRefGoogle Scholar
82.Rouzina, I. and Bloomfield, V.A., Biophys J. 74 (6) (1998) p. 3152CrossRefGoogle Scholar
83.Rouzina, I.F. and Bloomfield, V.A., Biophys J. 72 (2) (1997) p. 437Google Scholar
84.Li, A.Z. and Marx, K.A., Biophys J. 77 (1) (1999) p. 114CrossRefGoogle Scholar
85.Bloomfield, V.A., Biopolymers 44 (3) (1997) p. 2693.0.CO;2-T>CrossRefGoogle Scholar
86.Lai, E. and van Zanten, J.H., Biophys. J. 80 (2) (2001) p. 864CrossRefGoogle Scholar
87.Xu, Y. and Szoka, F.C. Jr., Biochemistry 35 (18) (1996) p. 5616CrossRefGoogle Scholar
88.Midoux, P., Mendes, C., Legrand, A., Raimond, J., Mayer, R., Monsigny, M., and Roche, A.C., Nucleic Acids Res. 21 (4) (1993) p. 871CrossRefGoogle Scholar
89.Ouahabi, A.El, Thiry, M., Pector, V., Fuks, R., Ruysschaert, J.M., and Vandenbranden, M., FEBS Lett. 414 (2) (1997) p. 187Google Scholar
90.Sosnowski, B.A., Gonzalez, A.M., Chandler, L.A., Buechler, Y.J., Pierce, G.F., and Baird, A., J. Biol. Chem. 271 (52) (1996) p. 33647CrossRefGoogle Scholar
91.Dunne, M., Bibby, D.C., Jones, J.C., and Cudmore, S., J. Controlled Release 92 (1–2) (2003) p. 209CrossRefGoogle Scholar
92.Kyriakides, T.R., Cheung, C.Y., Murthy, N., Bornstein, P., Stayton, P.S., and Hoffman, A.S., J. Controlled Release 78 (1–3) (2002) p. 295CrossRefGoogle Scholar
93.Boussif, O., Lezoualc'h, F., Zanta, M.A., Mergny, M.D., Scherman, D., Demeneix, B., and Behr, J.P., Proc. Natl. Acad. Sci. USA 92 (16) (1995) p. 7297CrossRefGoogle Scholar
94.Funhoff, A.M., van Nostrum, C.F., Koning, G.A., Schuurmans-Nieuwenbroek, N.M., Crommelin, D.J., and Hennink, W.E., Biomacromolecules 5 (1) (2004) p. 32CrossRefGoogle Scholar
95.Lechardeur, D., Sohn, K.J., Haardt, M., Joshi, P.B., Monck, M., Graham, R.W., Beatty, B., Squire, J., O'Brodovich, H., and Lukacs, G.L., Gene Ther. 6 (4) (1999) p. 482CrossRefGoogle Scholar
96. Submitted to Gene Ther. (2005)Google Scholar
97.Branden, L.J., Mohamed, A.J., and Smith, C.I., Nat. Biotechnol. 17 (8) (1999) p. 784CrossRefGoogle Scholar
98.Ziemienowicz, A., Gorlich, D., Lanka, E., Hohn, B., and Rossi, L., Proc. Natl. Acad. Sci. USA 96 (7) (1999) p. 3729CrossRefGoogle Scholar
99.Garrett, S.W., Davies, O.R., Milroy, D.A., Wood, P.J., Pouton, C.W., and Threadgill, M.D., Bioorg. Med. Chem. 8 (7) (2000) p. 1779CrossRefGoogle Scholar
100.Hong, J.W., Park, J.H., Huh, K.M., Chung, H., Kwon, I.C., and Jeong, S.Y., J. Controlled Release 99 (1) (2004) p. 167CrossRefGoogle Scholar
101.Rhaese, S., von Briesen, H., Rubsamen-Waigmann, H., Kreuter, J., and Langer, K., J. Controlled Release 92 (1–2) (2003) p. 199CrossRefGoogle Scholar
102.Vinogradov, S.V., Bronich, T.K., and Kabanov, A.V., Adv. Drug Deliv. Rev. 54 (1) (2002) p. 135CrossRefGoogle Scholar
103.Lemieux, P., Vinogradov, S.V., Gebhart, C.L., Guerin, N., Paradis, G., Nguyen, H.K., Ochietti, B., Suzdaltseva, Y.G., Bartakova, E.V., Bronich, T.K., St. Pierre, Y., Alakhov, V.Y., and Kabanov, A.V., “Block and graft copolymers and NanoGel copolymer networks for DNA delivery into cell,” J. Drug Target 8 (2) (2000) p. 91CrossRefGoogle Scholar
104.Bonadio, J., Smiley, E., Patil, P., and Goldstein, S., Nat. Med. 5 (7) (1999) p. 753CrossRefGoogle Scholar
105.Haider, M., Megeed, Z., and Ghandehari, H., J. Controlled Release 95 (1) (2004) p. 1CrossRefGoogle ScholarPubMed
106.Haider, M., Leung, V., Ferrari, F., Crissman, J., Powell, J., Cappello, J., and Ghandehari, H., Mol. Pharm. 2 (2) (2005) p. 139CrossRefGoogle Scholar
107.Megeed, Z., Cappello, J., and Ghandehari, H., Pharm. Res. 19 (7) (2002) p. 954CrossRefGoogle Scholar
108.Wang, C., Ge, Q., Ting, D., Nguyen, D., Shen, H.R., Chen, J., Eisen, H.N., Heller, J., Langer, R., and Putnam, D., Nat. Mater. 3 (3) (2004) p. 190CrossRefGoogle Scholar
109.Oster, C.G., Wittmar, M., Unger, F., Barbu-Tudoran, L., Schaper, A.K., and Kissel, T., Pharm. Res. 21 (6) (2004) p. 927CrossRefGoogle Scholar
110.McAllister, K., Sazani, P., Adam, M., Cho, M.J., Rubinstein, M., Samulski, R.J., and DeSimone, J.M., J. Am. Chem. Soc 124 (51) (2002) p. 15198CrossRefGoogle Scholar
111.Kabanov, A.V. and Alakhov, V.Y., Crit Rev. Ther. Drug Carrier Syst. 19 (1) (2002) p. 1CrossRefGoogle Scholar
112.Kabanov, A.V., Lemieux, P., Vinogradov, S., and Alakhov, V., Adv. Drug Deliv. Rev. 54 (2) (2002) p. 223CrossRefGoogle Scholar
113.Jones, R.A., Cheung, C.Y., Black, F.E., Zia, J.K., Stayton, P.S., Hoffman, A.S., and Wilson, M.R., Biochem. J. 372 (Pt. 1) (2003) p. 65CrossRefGoogle Scholar
114.Kiang, T., Bright, C., Cheung, C.Y., Stayton, P.S., Hoffman, A.S., and Leong, K.W., J. Biomater. Sci., Polym. Ed. 15 (11) (2004) p. 1405CrossRefGoogle Scholar