Hostname: page-component-cd9895bd7-7cvxr Total loading time: 0 Render date: 2024-12-25T15:06:06.044Z Has data issue: false hasContentIssue false
  • English
  • Français

New Directions in Photopolymerizable Biomaterials

Published online by Cambridge University Press:  31 January 2011

Kristi S. Anseth  and
Jason A. Burdick
Get access

Abstract

This article is based on the Outstanding Young Investigator Award presentation given by Kristi S. Anseth at the 2001 MRS Spring Meeting on April 17, 2001, in San Francisco. Anseth was recognized for “innovative work in polymeric biomaterials for drug delivery, bone and cartilage repair, and tissue engineering, and for outstanding leadership potential in this interdisciplinary field of materials research.”

Photopolymerization provides many advantages as a technique for the fabrication of biomaterials. Temporal and spatial control, along with the diversity in material properties found with photopolymerizable materials, are advantageous in the biomaterials industry. For instance, multifunctional anhydride monomers form highly cross-linked surface-eroding networks directly in bone defects. These networks have good mechanical properties that are maintained with degradation and have the potential to restore tissue-like properties to bone during the healing process. Additionally, cartilage-forming cells photoencapsulated in hydrogel networks secrete an extracellular matrix as the hydrogel is resorbed and may provide a treatment alternative for cartilage defects that do not heal spontaneously. Finally, transdermal polymerization (photopolymerization through the skin) of multifunctional monomers is a noninvasive technique that is being developed for tissue regeneration and wound-healing applications.

Keywords

biodegradationphotopolymerizationtissue engineering.
Type
Research Article
Information
MRS Bulletin , Volume 27 , Issue 2: Science and Technology of Shape-Memory Alloys: New Developments , February 2002 , pp. 130 - 136
Copyright
Copyright © Materials Research Society 2002

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1.Decker, C., J. Coating Technol. 59 (1987) p. 97.Google Scholar
2.Anseth, K.S., Newman, S.M., and Bowman, C.N., Adv. Polym. Sci. 122 (1995) p. 177.CrossRefGoogle Scholar
3.Hill-West, J., Chowdhury, S., Sawhney, A., Pathak, C., Dunn, R., and Hubbell, J., Obstet. Gynecol. 83 (1994) p. 59.Google Scholar
4.Brem, H., Walter, K.A., and Langer, R., Eur. J. Pharm. Biopharm. 39 (1993) p. 2;Google Scholar
Brem, H., Piantadosi, S., Burger, P.C., Walker, M., Selker, R., Vick, N.A., Black, K., Sisti, M., Brem, S., Mohr, G., Muller, P., Morawetz, R., Schold, S.C., and the Polymer-Brain Tumor Treatment Group, Lancet 345 (1995) p. 1008.CrossRefGoogle Scholar
5.Svaldi Muggli, D., Burkoth, A.K., and Anseth, K.S., J. Biomed. Mater. Res. 46 (1999) p. 271.3.0.CO;2-X>CrossRefGoogle Scholar
6.Kloosterboer, J., Adv. Polym. Sci. 84 (1988) p. 1.CrossRefGoogle Scholar
7.Svaldi Muggli, D., Burkoth, A.K., Keyser, S.A., Lee, H.R., and Anseth, K.S., Macromolecules 31 (1998) p. 4120.CrossRefGoogle Scholar
8.Anseth, K.S., Shastri, V.R., and Langer, R., Nat. Biotech. 17 (1999) p. 156.CrossRefGoogle Scholar
9.Burdick, J.A., Peterson, A.J., and Anseth, K.S., Biomaterials 22 (2001) p. 1779.CrossRefGoogle ScholarPubMed
10.Metters, A.T., Anseth, K.S., and Bowman, C.N., Polymer 41 (2000) p. 3993.CrossRefGoogle Scholar
11.Martens, P., Metters, A.T., Bowman, C.N., and Anseth, K.S., Soc. Biomater. Trans. 24 (2001) p. 312.Google Scholar
12.Bryant, S.J. and Anseth, K.S., J. Biomed. Mater. Res. 59 (2002) p. 63.CrossRefGoogle Scholar
13.Bryant, S.J. and Anseth, K.S., “Controlling the Spatial Distribution of ECM Components in Degradable PEG Hydrogels for Tissue Engineering Cartilage,” J. Biomed. Mater. Res. (2001) in press.CrossRefGoogle Scholar
14.Bryant, S.J. and Anseth, K.S., Soc. Biomater. Trans. 24 (2001) p. 77.Google Scholar
15.Bryant, S.J., Nuttelman, C.R., and Anseth, K.S., J. Biomater. Sci. Polym. Ed. 11 (2000) p. 439.CrossRefGoogle Scholar
16.Metters, A.T., Anseth, K.S., and Bowman, C.N., J. Phys. Chem. B 104 (2000) p. 7043.CrossRefGoogle Scholar
17.Armstrong, C.G. and Mow, V.C., J. Bone Joint Surg. Am. 64 (1982) p. 88.CrossRefGoogle Scholar
18.Kladny, B., Martus, P., Schiwy-Bochat, K.H., Weseloh, G., and Swoboda, B., Int. Orthop. 23 (1999) p. 264.CrossRefGoogle Scholar
19.Bryant, S.J. and Anseth, K.S., Biomaterials 22 (2001) p. 619.CrossRefGoogle Scholar
20.Elisseeff, J.E., Anseth, K., Sims, D., Randolph, M., and Langer, R., Proc. Natl. Acad. Sci. U.S.A. 96 (1999) p. 3104.CrossRefGoogle Scholar
21.Woodburne, R. and Burkel, W., Essentials of Human Anatomy (Oxford Press, Boca Raton, FL, 1994).Google Scholar
22.Svaldi Muggli, D.C., M.S. dissertation, University of Colorado, 1997.Google Scholar
23.Bryant, S., Martens, P., Elisseeff, J., Randolph, M., Langer, R., and Anseth, K., in Chemical and Physical Networks: Formation and Control of Properties, The Wiley Polymer Networks Group Review Series, Vol. 2, edited by Stokke, B.T. and Elgsaeter, A. (Wiley, New York, 1999) p. 395.Google Scholar
24.Urist, M.M., Maddox, W.A., Kennedy, J.E., and Balch, C.M., Cancer 51 (1988) p. 2152;3.0.CO;2-7>CrossRefGoogle Scholar
Aitken, D.R., Hunsaker, R., and James, A.G., Surg. Gynecol. Obstet. 158 (1984) p. 827.Google Scholar
25.Lindsey, W.H., Masterson, T.M., Spotnitz, W.D., Wilhelm, M.C., and Morgan, R.F., Arch. Surg. 125 (1990) p. 305.CrossRefGoogle Scholar