Hostname: page-component-586b7cd67f-t8hqh Total loading time: 0 Render date: 2024-11-26T20:53:08.819Z Has data issue: false hasContentIssue false
  • English
  • Français

Materials for biointegrated electronic and microfluidic systems

Published online by Cambridge University Press:  11 March 2019

John A. Rogers
John A. Rogers*
Affiliation:
Northwestern University, USA; [email protected]
Get access

Abstract

This article provides an overview of emerging directions in the materials science of biointegrated electronic and microfluidic systems, as defined by technologies that are capable of supporting long-term, intimate, physical interfaces to living organisms. Here, deterministic hard/soft composite structures, including those that leverage concepts in fractal mathematics, serve as the materials foundations for diverse devices of this type. Examples of “epidermal” or skin-like electronic systems for biophysical tracking of patient conditions that range from stroke to hydrocephalus illustrate the engineering maturity and operational sophistication that is now possible. Recent ideas in soft, skin-mounted, microfluidic lab-on-a-chip systems extend the capabilities of such platforms to include biochemical assessments of physiological status via capture, storage, manipulation, and in situ detection of biomarkers in microliter volumes of sweat, collected as it emerges from the surface of the skin. The article concludes with a description of mechanically guided assembly schemes that provide access to three-dimensional, open-mesh constructs, as a frontier area of materials development in this broader area of biointegrated systems.

Keywords

biomedicalcompositesensorsemiconductingtissue
Type
Technical Feature
Information
MRS Bulletin , Volume 44 , Issue 3: Self-Assembled Porphyrin and Macrocycle Derivatives , March 2019 , pp. 195 - 202
Copyright
Copyright © Materials Research Society 2019 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

1

This article is based on the MRS Medal presentation given by John A. Rogers, Northwestern University, at the 2018 MRS Fall Meeting in Boston, Mass.

References

Kim, D.-H., Lu, N., Ma, R., Kim, Y.-S., Kim, R.-H., Wang, S., Wu, J., Won, S.M., Tao, H., Islam, A., Yu, K.J., Kim, T.-I., Chowdhury, R., Ying, M., Xu, L., Li, M., Chung, H.-J., Keum, H., McCormick, M., Liu, P., Zhang, Y.-W., Omenetto, F.G., Huang, Y., Coleman, T., Rogers, J.A., Science 333, 838 (2011).CrossRefGoogle Scholar
Viventi, J., Kim, D.-H., Vigeland, L., Frechette, E.S., Blanco, J.A., Kim, Y.-S., Avrin, A.E., Tiruvadi, V.R., Hwang, S.-W., Vanleer, A.C., Wulsin, D.F., Davis, K., Gelber, C.E., Palmer, L., Van der Spiegel, J., Wu, J., Xiao, J., Huang, Y., Contreras, D., Rogers, J.A., Litt, B., Nat. Neurosci. 14, 1599 (2011).CrossRefGoogle Scholar
Xu, L., Gutbrod, S.R., Bonifas, A.P., Su, Y., Sulkin, M.S., Lu, N., Chung, H.-J., Jang, K.-I., Liu, Z., Ying, M., Lu, C., Webb, R.C., Kim, J.-S., Laughner, J.I., Cheng, H., Liu, Y., Ameen, A., Jeong, J.-W., Kim, G.-T., Huang, Y., Efimov, I.R., Rogers, J.A., Nat. Commun. 5, 3329 (2014).CrossRefGoogle Scholar
Kim, T.-I., McCall, J.G., Jung, Y.H., Huang, X., Siuda, E.R., Li, Y., Song, J., Song, Y.M., Pao, H.A., Kim, R.-H., Lu, C., Lee, S.D., Song, I.-S., Shin, G., Al-Hasani, R., Kim, S., Tan, M.P., Huang, Y., Omenetto, F.G., Rogers, J.A., Bruchas, M.R., Science 240, 211 (2013).CrossRefGoogle Scholar
Shin, G., Gomez, A.M., Al-Hasani, R., Jeong, Y.R., Kim, J., Xie, Z., Banks, A., Lee, S.M., Han, S.Y., Yoo, C.J., Lee, J.-L., Lee, S.H., Kurniawan, J., Tureb, J., Guo, Z., Yoon, J., Park, S.-I., Bang, S.Y., Nam, Y., Walicki, M.C., Samineni, V.K., Mickle, A.D., Lee, K., Heo, S.Y., McCall, J.G., Pan, T., Wang, L., Feng, X., Kim, T.-I., Kim, J.K., Li, Y., Huang, Y., Gereau IV, R.W., Ha, J.S., Bruchas, M.R., Rogers, J.A., Neuron 93, 509 (2017).CrossRefGoogle Scholar
Lu, L., Gutruf, P., Xia, L., Bhatti, D.L., Wang, X., Vazquez-Guardado, A., Ning, X., Shen, X., Sang, T., Ma, R., Pakeltis, G., Sobczak, G., Zhang, H., oh Seo, D., Xue, M., Yin, L., Chanda, D., Sheng, X., Bruchas, M.R., Rogers, J.A., Proc. Natl. Acad. Sci. U.S.A. 15 (7), E1374 (2018).CrossRefGoogle Scholar
Won, S.M., Song, E., Zhao, J., Li, J., Rivnay, J., Rogers, J.A., Adv. Mater. 30, 1800534 (2018).CrossRefGoogle Scholar
Hwang, S.-W., Tao, H., Kim, D.-H., Cheng, H., Song, J.-K., Rill, E., Brenckle, M.A., Panilaitis, B., Won, S.M., Kim, Y.-S., Song, Y.M., Yu, K.J., Ameen, A., Li, R., Su, Y., Yang, M., Kaplan, D.L., Zakin, M.R., Slepian, M.J., Huang, Y., Omenetto, F.G., Rogers, J.A., Science 337, 1640 (2012).CrossRefGoogle Scholar
Yu, K.J., Kuzum, D., Hwang, S.-W., Kim, B.H., Juul, H., Kim, N.H., Won, S.M., Chiang, K., Trumpis, M., Richardson, A.G., Cheng, H., Fang, H., Thompson, M., Bink, H., Talos, D., Seo, K.J., Lee, H.N., Kang, S.-K., Kim, J.-H., Lee, J.Y., Huang, Y., Jensen, F.E., Dichter, M.A., Lucas, T.H., Viventi, J., Litt, B., Rogers, J.A., Nat. Mater. 15, 782 (2016).CrossRefGoogle Scholar
Kang, S.-K., Murphy, R.K.J., Hwang, S.-W., Lee, S.M., Harburg, D.V., Krueger, N.A., Shin, J., Gamble, P., Cheng, H., Yu, S., Liu, Z., McCall, J.G., Stephen, M., Ying, H., Kim, J., Park, G., Webb, R.C., Lee, C.H., Chung, S., Wie, D.S., Gujar, A.D., Vemulapalli, B., Kim, A.H., Lee, K.-M., Cheng, J., Huang, Y., Lee, S.H., Braun, P.V., Ray, W.Z., Rogers, J.A., Nature 530, 71 (2016).CrossRefGoogle Scholar
Koo, J., MacEwan, M.R., Kang, S.-K., Won, S.M., Stephen, M., Gamble, P., Xie, Z., Yan, Y., Chen, Y.-Y., Shin, J., Birenbaum, N., Chung, S., Kim, S.B., Khalifeh, J., Harburg, D.V., Bean, K., Paskett, M., Kim, J., Zohny, Z.S., Lee, S.M., Zhang, R., Luo, K., Ji, B., Banks, A., Lee, H.M., Huang, Y., Ray, W.Z., Rogers, J.A., Nat. Med. 24, 1830 (2018).CrossRefGoogle Scholar
Kang, S.-K., Koo, J., Lee, Y.K., Rogers, J.A., Acc. Chem. Res. 51, 988 (2018).CrossRefGoogle Scholar
Xu, S., Yan, Z., Jang, K.-I., Huang, W., Fu, H., Kim, J., Wei, Z., Flavin, M., McCracken, J., Wang, R., Badea, A., Liu, Y., Xiao, D., Zhou, G., Lee, J., Chung, H.U., Cheng, H., Ren, W., Banks, A., Li, X., Paik, U., Nuzzo, R.G., Huang, Y., Zhang, Y., Rogers, J.A., Science 347, 154 (2015).CrossRefGoogle ScholarPubMed
Yan, Z., Han, M., Shi, Y., Badea, A., Yan, Y., Kulkarni, A., Hanson, E., Kandel, M.E., Wen, X., Zhang, F., Luo, Y., Lin, Q., Zhang, H., Guo, X., Huang, Y., Nan, K., Jia, S., Oraham, A.W., Mevis, M.B., Lim, J., Guo, X., Gao, M., Ryu, W., Yu, K.J., Nicolau, B.G., Petronico, A., Rubakhin, S.S., Lou, J., Ajayan, P.M., Thornton, K., Popescu, G., Fang, D., Sweedler, J.V., Braun, P.V., Zhang, H., Nuzzo, R.G., Huang, Y., Zhang, Y., Rogers, J.A., Proc. Nat. Acad. Sci. U.S.A. 114 (45), E9455 (2017).CrossRefGoogle Scholar
Fu, H., Nan, K., Bai, W., Huang, W., Bai, K., Lu, L., Zhou, C., Liu, Y., Liu, F., Wang, J., Han, M., Yan, Z., Luan, H., Zhang, Y., Zhang, Y., Zhao, J., Cheng, X., Li, M., Lee, J.W., Liu, Y., Fang, D., Li, X., Huang, Y., Zhang, Y., Rogers, J.A., Nat. Mater. 17, 268 (2018).CrossRefGoogle Scholar
Rogers, J.A., Someya, T., Huang, Y., Science 327, 1603 (2010).CrossRefGoogle Scholar
Rogers, J.A., Lagally, M.G., Nuzzo, R.G., Nature 477, 45 (2011).CrossRefGoogle Scholar
Yoder, M.A., Yan, Z., Han, M., Rogers, J.A., Nuzzo, R.G., J. Am. Chem. Soc. 140, 9001 (2018).CrossRefGoogle Scholar
Jang, K.-I., Chung, H.U., Xu, S., Lee, C.H., Luan, H., Jeong, J., Cheng, H., Kim, G.-T., Han, S.Y., Lee, J.W., Kim, J., Cho, M., Miao, F., Yang, Y., Jung, H.N., Flavin, M., Liu, H., Kong, G.W., Yu, K.J., Rhee, S.I., Chung, J., Kim, B., Kwak, J.W., Yun, M.H., Kim, J.Y., Song, Y.M., Paik, U., Zhang, Y., Huang, Y., Rogers, J.A., Nat. Commun. 6, 6566 (2015).CrossRefGoogle Scholar
Fan, J.A., Yeo, W.-H., Su, Y., Hattori, Y., Lee, W., Jung, S.-Y., Zhang, Y., Liu, Z., Cheng, H., Falgout, L., Bajema, M., Coleman, T., Gregoire, D., Larsen, R.J., Huang, Y., Rogers, J.A., Nat. Commun. 5, 3266 (2014).CrossRefGoogle Scholar
Xu, S., Zhang, Y., Jia, L., Mathewson, K.E., Jang, K.-I., Kim, J., Fu, H., Huang, X., Chava, P., Wang, R., Bhole, S., Wang, L., Na, Y.J., Guan, Y., Flavin, M., Han, Z., Huang, Y., Rogers, J.A., Science 344, 70 (2014).CrossRefGoogle Scholar
Ray, T., Ghaffari, R., Bandodkar, A., Krishnan, S., Choi, J., Rogers, J.A., Chem. Rev., doi:10.1021/acs.chemrev.8b00573.Google Scholar
Heikenfeld, J., Jajack, A., Rogers, J., Gutruf, P., Tian, L., Pan, T., Li, R., Khine, M., Kim, J., Wang, J., Kim, J., Lab Chip 18, 217 (2018).CrossRefGoogle Scholar
Rogers, J., Malliaras, G., Someya, T., Sci. Adv. 4 (9), eaav1889 (2018).CrossRefGoogle Scholar
Webb, R.C., Bonifas, A.P., Behnaz, A., Zhang, Y., Yu, K.J., Cheng, H., Shi, M., Bian, Z., Liu, Z., Kim, Y.S., Yeo, W.-H., Park, J.S., Song, J., Li, Y., Huang, Y., Gorbach, A.M., Rogers, J.A., Nat. Mater. 12, 938 (2013).CrossRefGoogle Scholar
Webb, R.C., Ma, Y., Krishnan, S., Li, Y., Yoon, S., Guo, X., Feng, X., Shi, Y., Seidel, M., Cho, N.H., Kurniawan, J., Ahad, J., Sheth, N., Kim, J., Taylor, J.G., Darlington, T., Chang, K., Huang, W., Ayers, J., Gruebele, A., Pielak, R.M., Slepian, M.J., Huang, Y., Gorbach, A.M., Rogers, J.A., Sci. Adv. 1 (9), e1500701 (2015).CrossRefGoogle Scholar
Liu, Y., Tian, L., Raj, M.S., Cotton, M., Ma, Y., Ma, S., McGrane, B., Pendharkar, A.V., Dahaleh, N., Olson, L., Luan, H., Block, O., Suleski, B., Zhou, Y., Jayaraman, C., Koski, T., Aranyosi, A.J., Wright, J.A., Jayaraman, A., Huang, Y., Ghaffari, R., Kliot, M., Rogers, J.A., NPJ Digit. Med . 1, 19 (2018).CrossRefGoogle Scholar
Lonini, L., Dai, A., Shawen, N., Simuni, T., Poon, C., Shimanovich, L., Daeschler, M., Ghaffari, R., Rogers, J.A., Jayaraman, A., NPJ Digit. Med. 1, 64 (2018).CrossRefGoogle Scholar
Koh, A., Kang, D., Xue, Y., Lee, S., Pielak, R.M., Kim, J., Hwang, T., Min, S., Banks, A., Bastien, P., Manco, M.C., Wang, L., Ammann, K.R., Jang, K.-I., Won, P., Han, S., Ghaffari, R., Paik, U., Slepian, M.J., Balooch, G., Huang, Y., Rogers, J.A., Sci. Transl. Med. 8 (366), 366ra165 (2016).CrossRefGoogle Scholar
Choi, J., Ghaffari, R., Baker, L.B., Rogers, J.A., Sci. Adv. 4 (2), eaar3921 (2018).CrossRefGoogle Scholar
Krishnan, S.R., Ray, T.R., Ayer, A.B., Ma, Y., Gutruf, P., Lee, K.H., Lee, J.Y., Wei, C., Feng, X., Ng, B., Abecassis, Z.A., Murthy, N., Stankiewicz, I., Freudman, J., Stillman, J., Kim, N., Young, G., Goudeseune, C., Ciraldo, J., Tate, M., Huang, Y., Potts, M., Rogers, J.A., Sci. Transl. Med. 10 (465), eaat8437 (2018).CrossRefGoogle Scholar
Zhang, Y., Zhang, F., Yan, Z., Ma, Q., Li, X., Huang, Y., Rogers, J.A., Nat. Rev. Mater. 2, 17019 (2017).CrossRefGoogle Scholar