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DNA origami devices for molecular-scale precision measurements

Published online by Cambridge University Press:  08 December 2017

Carlos E. Castro ,
Hendrik Dietz  and
Björn Högberg
Carlos E. Castro
Affiliation:
Department of Mechanical and Aerospace Engineering, The Ohio State University, USA; [email protected]
Hendrik Dietz
Affiliation:
Technische Universität München, Germany; [email protected]
Björn Högberg
Affiliation:
Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Sweden; [email protected]
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Abstract

Structural DNA nanotechnology offers the capacity to construct ultraminiaturized devices with programmed nanoscale geometry, mechanical and dynamic properties, and site-specific molecular functionalities. These features and the possibility to position and orient molecules in user-defined ways may be exploited to create custom instruments for precision measurements of molecular-scale structure, dynamics, and interactions. Such devices may help constrain molecular motion along interesting reaction coordinates and may also exert forces to probe the mechanical properties or dynamics of molecules under study. Multiple ways of reading out device states may be used, including atomic force microscopy or transmission electron microscopy imaging, single-molecule or bulk fluorescence, or ionic conductivity as in nanopore systems. Early successes with custom scientific instruments based on DNA origami underline the tremendous potential to enable new approaches to making scientific discoveries in biological and synthetic materials systems.

Type
Research Article
Information
MRS Bulletin , Volume 42 , Issue 12: DNA Nanotechnology: A foundation for Programmable Nanoscale Materials , December 2017 , pp. 925 - 929
Copyright
Copyright © Materials Research Society 2017 

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