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3D printing for regenerative medicine: From bench to bedside

Published online by Cambridge University Press:  12 February 2015

Juan Li ,
Ling He ,
Chen Zhou ,
Yue Zhou ,
Yanying Bai ,
Francis Y. Lee  and
Jeremy J. Mao
Juan Li
Affiliation:
Columbia University, USA, and Sichuan University, China
Ling He
Affiliation:
Columbia University, USA; [email protected]
Chen Zhou
Affiliation:
Columbia University, USA; [email protected]
Yue Zhou
Affiliation:
Columbia University, USA; [email protected]
Yanying Bai
Affiliation:
Columbia University, USA
Francis Y. Lee
Affiliation:
Columbia University, USA; [email protected]
Jeremy J. Mao
Affiliation:
Columbia University, USA; [email protected]
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Abstract

Organ shortage is a severe challenge worldwide. Three-dimensional (3D) printing, a rapidly developing engineering and materials science tool, holds considerable promise in generating implantable organ scaffolds that may reduce or eliminate organ shortage. However, translation of 3D printing into clinical therapies has been astonishingly slow and certainly has not matched the pace of technology development. This review outlines challenges and opportunities for the application of 3D printing in tissue and organ regeneration, with emphasis on in vivo applications of 3D-printed scaffolds. Three-dimensional-printed scaffolds for the regeneration of complex tissues and organs, including bone, cartilage, tooth, and skin, serve as prototypes for 3D printing of other tissues and organs such as the liver, kidney, or heart. The aspiration to reduce or eliminate organ shortage appears to hinge on the translation of 3D bioprinting technologies into preclinical studies and clinical trials. The remaining challenges of cell survival, directed differentiation, angiogenesis, and metabolic exchange are far from trial and need to be addressed. Three-dimensional-printed materials will remain a biomaterials and engineering showcase unless applications in preclinical and clinical models are realized. In balance, 3D printing holds considerable promise in regenerative medicine as a unique approach to address organ shortage.

Keywords

biomaterialbiological synthesis (assembly)inkjet printinglithography (deposition)biomedical
Type
Research Article
Information
MRS Bulletin , Volume 40 , Issue 2: 3D printing of biomaterials , February 2015 , pp. 145 - 154
Copyright
Copyright © Materials Research Society 2015 

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