Hostname: page-component-586b7cd67f-gb8f7 Total loading time: 0 Render date: 2024-11-22T20:29:50.923Z Has data issue: false hasContentIssue false
  • English
  • Français

Sonochemically Synthesized ZnO Nanostructure-Based L-Lactate Enzymatic Sensors on Flexible Substrates

Published online by Cambridge University Press:  16 January 2018

Fahmida Alam ,
Ahmed Hasnain Jalal ,
Raju Sinha ,
Yogeswaran Umasankar ,
Shekhar Bhansali  and
Nezih Pala
Fahmida Alam*
Affiliation:
Department of Electrical and Computer Engineering, Florida International University, Miami, Florida – 33174, United States.
Ahmed Hasnain Jalal
Affiliation:
Department of Electrical and Computer Engineering, Florida International University, Miami, Florida – 33174, United States.
Raju Sinha
Affiliation:
Department of Electrical and Computer Engineering, Florida International University, Miami, Florida – 33174, United States.
Yogeswaran Umasankar
Affiliation:
Department of Electrical and Computer Engineering, Florida International University, Miami, Florida – 33174, United States.
Shekhar Bhansali
Affiliation:
Department of Electrical and Computer Engineering, Florida International University, Miami, Florida – 33174, United States.
Nezih Pala
Affiliation:
Department of Electrical and Computer Engineering, Florida International University, Miami, Florida – 33174, United States.
*
*(Email: [email protected])
Get access

Abstract

We report on highly sensitive and flexible L-lactate enzymatic sensors. The sensing materials of this biosensor, two-dimensional (2D) zinc oxide nanoflakes (ZnO NFs), are synthesized on flexible gold(Au)-coated polyethylene terephthalate (PET) substrate using one step sonochemical approach for non-invasive lactate monitoring in human perspiration. ZnO NFs show high isoelectric points (IEP) and biocompatibility. Taking advantage of these unique properties, we immobilized Lactate oxidase (LOx) on the synthesized ZnO NFs. PET/Au/ZnO NFs sensors demonstrated detection of lactate in the range of 10 pM-10 µM for the electrode area of 0.5×0.5 cm2. The sensitivity of this linker free lactate sensor was found 2.23μA/M /cm2 and shows 4 times better response than conventional Au electrode with linker.

Keywords

nanostructurescanning electron microscopy (SEM)sensor
Type
Articles
Information
MRS Advances , Volume 3 , Issue 5: Electronics, Magnetics and Photonics , 2018 , pp. 277 - 282
Check for updates
Copyright
Copyright © Materials Research Society 2018 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Pundir, C.S., Narwal, V. and Batra, B., Biosens. and Bioelec., 86, 777 (2016).Google Scholar
Kruse, J. A., Zaidi, S.A. and Carlton, R.W., Am J. Med, 83(1), 77 (1987).Google Scholar
Sayeed, M.M. and Murthy, P.N.A., Circ Shock, 8(6), 657 (1981).Google ScholarPubMed
Bellomo, R., Crit. Care 6(4), 322 (2002).Google Scholar
Rimachi, R., de Carvahlo, F.B., Orellano-Jimenez, C., Cotton, F., Vncent, J.L. and de Backer, D., Anaesth. Intens. Care, 40(3), 427 (2012).Google Scholar
DeBacke, D., Ceteu, J., Zhang, H.B, Norrenberg, M. and Vincent, J.L., Am J. Respir Crit. Care Med, 156 (4 Pt 1), 1099 (1997).CrossRefGoogle Scholar
White, N.J., Sci. Transl. Med., 7, 278ec43 (2015).Google Scholar
Smith, I., Kumar, P., Molloy, S., Rhodes, A., Newman, P.J., Grounds, R.M. and Bennett, E.D., Intens. Care Med, 27(1),74 (2001).Google Scholar
Vabbina, P. K., Kaushik, A., Pokhrel, N., Bhansali, S. and Pala, N., Biosens. and Bioelec., 63, 124 (2015).Google Scholar
Alam, F., Sinha, R., Jalal, A.H., Manickam, P., Vabbina, P.K., Bhansali, S. and Pala, N., 232nd ECS Conf., Maryland (2017).Google Scholar
Shay, T., Dickey, M.D., and Velev, O.D.. "Hydrogel-enabled osmotic pumping for microfluidics: towards wearable human-device interfaces." Lab on a Chip 17.4 (2017): 710–716.Google Scholar
Gao, W., Emaminejad, S., Nyein, H.Y.Y., Challa, S., Chen, K., Peck, A., Fahad, H.M., Ota, H., Shiraki, H., Kiriya, D., Lien, D.-H., Brooks, G.A., Davis, R.W. and Javey, A., "Fully integrated wearable sensor arrays for multiplexed in situ perspiration analysis." Nature 529, 509 (2016).Google Scholar