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Poly(HDDA)-Based Polymers for Microfabrication and Mechanobiology

Published online by Cambridge University Press:  16 January 2017

Daniela Espinosa-Hoyos ,
Huifeng Du ,
Nicholas X. Fang  and
Krystyn J. Van Vliet
Daniela Espinosa-Hoyos*
Affiliation:
Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139 Biosystems & Micromechanics Interdisciplinary Research Group (BioSyM), Singapore-MIT Alliance in Research & Technology (SMART), Singapore
Huifeng Du*
Affiliation:
Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139
Nicholas X. Fang
Affiliation:
Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139
Krystyn J. Van Vliet
Affiliation:
Biosystems & Micromechanics Interdisciplinary Research Group (BioSyM), Singapore-MIT Alliance in Research & Technology (SMART), Singapore Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139 Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139 Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139
*
*(Email: [email protected])

Abstract

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Materials processing and additive manufacturing afford exciting opportunities in biomedical research, including the study of cell-material interactions. However, some of the most efficient materials for microfabrication are not wholly suitable for biological applications, require extensive post-processing or exhibit high mechanical stiffness that limits the range of applications. Conversely, materials exhibiting high cytocompatibility and low stiffness require long processing times with typically decreased spatial resolution of features. Here, we investigated the use of hexanediol diacrylate (HDDA), a classic and efficient polymer for stereolithography, for oligodendrocyte progenitor cell (OPC) culture. We developed composite HDDA-polyethylene glycol acrylate hydrogels that exhibited high biocompatibility, mechanical stiffness in the range of muscle tissue, and high printing efficiency at ∼5 μm resolution.

Keywords

biomedicalpolymermicrostructure
Type
Articles
Information
MRS Advances , Volume 2 , Issue 24: Biomaterials and Soft Materials , 2017 , pp. 1315 - 1321
Copyright
Copyright © Materials Research Society 2017 

References

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