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Microfluidic Synthesis of Lipid-Polymer Hybrid Nanoparticles for Targeted Drug Delivery

Published online by Cambridge University Press:  14 June 2016

Eri A. Takami  and
Folarin Erogbogbo
Eri A. Takami*
Affiliation:
Biomedical, Chemical, and Materials Science Engineering Department, San Jose State University, San Jose, CA 95192, U.S.A.
Folarin Erogbogbo
Affiliation:
Biomedical, Chemical, and Materials Science Engineering Department, San Jose State University, San Jose, CA 95192, U.S.A.
*
*(Email: [email protected])
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Abstract

Lipid-polymer hybrid nanoparticles (LPHN) have great potential as drug delivery devices for treatment of serious medical issues such as cardiovascular disease, tuberculosis, and cancer. Nanoprecipitation is a commonly used method to synthesize LPHN in a low cost manner. However, this multi-step process proves to be difficult in consistently producing uniformly sized nanoparticles. Here we developed a microfluidic device that utilizes a three-channel pathway and mixer channel to synthesize uniformly sized LPHN in a controlled manner. Dynamic light scattering results of the microfluidic synthesized nanoparticles show decrease in diameter size from 140 nm to 40 nm as the Reynolds number of the channel inflow increases. Transmission electron microscopy confirms the size and morphology of the nanoparticles. Three dimensional structure of the LPHN were observed using atomic force microscopy. The production of higher quality nanoparticles using our microfluidics device can expedite the research and development process of drug delivering lipid polymer nanoparticles.

Keywords

transmission electron microscopy (TEM)biomedicalfluidics
Type
Articles
Information
MRS Advances , Volume 1 , Issue 29: Soft Materials and Biomaterials , 2016 , pp. 2155 - 2160
Copyright
Copyright © Materials Research Society 2016 

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References

REFERENCES

Xu, Q., Kambhampati, S., and Kannan, R.. “Nanotechnology approaches for ocular drug delivery,” Middle East Afr J Ophthalmol, 20, 26–37 (2013).Google Scholar
Chan, J., Zhang, L., Yuet, K., Liao, G., Rhee, J., Langer, R., and Farokhzad, O., “PLGA-lecithin-PEG core-shell nanoparticles for controlled drug delivery,” Biomaterials. 30, 1627–1634 (2009).CrossRefGoogle Scholar
Mudshinge, S., Deore, A., Patil, S., and Saudi, C. “Nanoparticles: Emerging carriers for drug delivery,” Pharmaceutical Journal, 10, 1016 (2011).Google Scholar
Raemdonck, K., Braeckmans, K., Demeester, J., De Smedt, S.. “Merging the best of both worlds: hybrid lipid-enveloped matrix nanocomposites in drug delivery,” Chemical Society Reviews, 10, 1039 (2014).Google Scholar
Chan, J., Rhee, J., Drum, C., Bronson, R., Golomb, G., Langer, R., Farokhzad, O., “In vivo prevention of arterial restenosis with paclitaxel-encapsulated targeted lipid–polymeric nanoparticles,” Proceedings of the National Academy of Sciences, 10, 1073 (2011).Google Scholar
Hadinoto, K., Sundaresan, A., and Cheow, W., “Lipid-polymer hybrid nanoparticles as a new generation therapeutic delivery platform: a review,” European journal of pharmaceutics and biopharmaceutics, 85, 427–43 (2013).CrossRefGoogle Scholar
Fang, R., Aryal, S., Hu, C., and Zhang, L., “Quick synthesis of lipid-polymer hybrid nanoparticles with low polydispersity using a single-step sonication method,” Langmuir, 26, 16958–62 (2010).CrossRefGoogle Scholar
Zhang, L., Chan, J.M., Gu, F.X., Rhee, J., Wang, A., Radovic-Moreno, A., Alexis, F., Langer, R., and Farokhzad, O., “Self-assembled lipid–polymer hybrid nanoparticles: a robust drug delivery platform,” ACS nano. 2, 1696–702 (2008).CrossRefGoogle Scholar
Farokhzad, O., Khademhosseini, A., Jon, S., Hermmann, A., Cheng, J., Chin, C., Kiselyuk, A., Teply, B., Eng, G., and Langer, R., “Microfluidic System for Studying the Interaction of Nanoparticles and Microparticles with Cells,” Analytical Chemistry. 77, 5453–5459 (2005).CrossRefGoogle Scholar
Kim, Y., Chung, B., Ma, M., Mulder, W., Fayad, Z., Farokhzad, O., , R. and Langer, , “Mass production and size control of lipid-polymer hybrid nanoparticles through controlled microvortices,” Nano letters. 12, 3587–91 (2012).CrossRefGoogle Scholar