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Laser Application of Nanocomposite Hydrogels on Cancer Cell Viability

Published online by Cambridge University Press:  17 April 2020

Y. Danyuo ,
A. A. Salifu ,
J. D. Obayemi ,
C. J. Ani ,
S. Dozie-Nwachukwu ,
Theresa Ezenwafor  and
J. Yirijor
Y. Danyuo*
Affiliation:
Department of Mechanical Engineering, Ashesi University, Berekuso, Ghana Department of Materials Science and Engineering, African University of Science and Technology, Federal Capital Territory, Abuja, Nigeria
A. A. Salifu
Affiliation:
Department of Mechanical Engineering, Worcester Polytechnic Institute, 100 Institute Road, Worcester, MA 01609, USA.
J. D. Obayemi
Affiliation:
Department of Mechanical Engineering, Worcester Polytechnic Institute, 100 Institute Road, Worcester, MA 01609, USA.
C. J. Ani
Affiliation:
Department of Theoretical and Applied Physics, African University of Science and Technology (AUST), Km 10, Airport Road, Federal Capital Territory, Abuja Nigeria
S. Dozie-Nwachukwu
Affiliation:
Biotechnology Advance Research Center, Sheda Science and Technology Complex (SHESTCO), Abuja, Federal Capital Territory, Nigeria
Theresa Ezenwafor
Affiliation:
Department of Materials Science and Engineering, African University of Science and Technology, Federal Capital Territory, Abuja, Nigeria
J. Yirijor
Affiliation:
Academic City College, Department of Mechanical Engineering, Haatso-Accra, Ghana
*
*Corresponding Author: Email: [email protected], Mobile: +233550505434.
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Abstract

Nanocomposite hydrogels of poly-n-isopropyl were prepared by incorporating gold and magnetite nanoparticles. The nanocomposite-based hydrogels formed were geometrical, ∼7.3 mm in diameter and 5 mm thick (in the swollen state). Morphological analysis was characterized by a scanning electron microscope. Drug-loaded hydrogels were subjected to laser heating at 1 W, 1.5 W and 2 W for 20 min in each laser cycle. The metabolic activities of the cells were analysed. The photothermal conversion efficiency of the nanocomposite hydrogels was also evaluated for P(NIPA)-AuNP-PG and P(NIPA)-MNP-PG to be 36.93 and 32.57 %, respectively. The result was then discussed for potential applications whereby metal-based hydrogels can be employed in microfluidic devices for targeted cancer drug delivery.

Keywords

biomaterialdeviceslaser ablationmagnetic propertiespolymerization
Type
Articles
Information
MRS Advances , Volume 5 , Issue 26: African Materials Research Society 2019 , 2020 , pp. 1377 - 1385
Copyright
Copyright © Materials Research Society 2020

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