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Fabrication and Characterization of Biodegradable Metal Based Microelectrodes for In Vivo Neural Recording

Published online by Cambridge University Press:  16 July 2019

Chaoxing Zhang ,
Teresa H. Wen ,
Khaleel A. Razak ,
Jiajia Lin ,
Edgar Villafana ,
Hector Jimenez  and
Huinan Liu
Chaoxing Zhang
Affiliation:
Materials Science and Engineering Program, University of California at Riverside, 900 University Avenue, Riverside, CA92521, United States Department of Bioengineering, University of California at Riverside, 900 University Avenue, Riverside, CA92521, United States
Teresa H. Wen
Affiliation:
Neuroscience Graduate Program, University of California Riverside, 900 University Avenue, Riverside, CA92521, United States
Khaleel A. Razak
Affiliation:
Neuroscience Graduate Program, University of California Riverside, 900 University Avenue, Riverside, CA92521, United States Psychology Department, University of California Riverside, 900 University Avenue, Riverside, CA92521, United States
Jiajia Lin
Affiliation:
Materials Science and Engineering Program, University of California at Riverside, 900 University Avenue, Riverside, CA92521, United States Department of Bioengineering, University of California at Riverside, 900 University Avenue, Riverside, CA92521, United States
Edgar Villafana
Affiliation:
Department of Bioengineering, University of California at Riverside, 900 University Avenue, Riverside, CA92521, United States
Hector Jimenez
Affiliation:
Department of Bioengineering, University of California at Riverside, 900 University Avenue, Riverside, CA92521, United States
Huinan Liu*
Affiliation:
Materials Science and Engineering Program, University of California at Riverside, 900 University Avenue, Riverside, CA92521, United States Department of Bioengineering, University of California at Riverside, 900 University Avenue, Riverside, CA92521, United States Biomedical Sciences Program, School of Medicine, University of California at Riverside, 900 University Avenue, Riverside, CA92521, United States Stem Cell Center, University of California at Riverside, 900 University Avenue, Riverside, CA92521, USA
*
*(Email: [email protected])
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Abstract:

Neural electrodes have been widely used to monitor neural signals and/or deliver electrical stimulation in the brain. Currently, biodegradable and biocompatible materials have been actively investigated to create temporary electrodes that could degrade after serving their functions for neural recording and stimulation from days to months. The new class of biodegradable electrodes eliminate the necessity of secondary surgery for electrode removal. In this study, we created biodegradable, biocompatible, and implantable magnesium (Mg)-based microelectrodes for in vivo neural recording for the first time. Specifically, conductive poly-3,4-ethylenedioxythiophene (PEDOT) was first deposited onto Mg microwire substrates by electrochemical deposition, and a biodegradable insulating polymer was subsequently sprayed onto the surface of electrodes. The tip of electrodes was designed to be conductive for neural recording and stimulation, while the rest of electrodes was insulated with a polymer that is biocompatible with neural tissue. The impedance of Mg-based microelectrodes and their performance during neural recording in the auditory cortex of a mouse were studied. The results first demonstrated the capability of Mg-based microelectrodes for in vivo recording of multi-unit stimulus-evoked activity in the brain.

Keywords

biomedicalbiomaterialelectrodeposition
Type
Articles
Information
MRS Advances , Volume 4 , Issue 46-47: Soft Materials and Biomaterials , 2019 , pp. 2471 - 2477
Copyright
Copyright © Materials Research Society 2019 

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References

Harris, A. R., Morgan, S. J., Chen, J., Kapsa, R. M. I., Wallace, G. G. and Paolini, A. G., Journal of Neural Engineering 10 (1) (2013).CrossRefGoogle Scholar
Cogan, S. F., Annual Review of Biomedical Engineering 10, 275-309 (2008).CrossRefGoogle Scholar
Jeong, J. W., Shin, G., Park, S. I., Yu, K. J., Xu, L. and Rogers, J. A., Neuron 86 (1), 175-186 (2015).CrossRefGoogle Scholar
Kim, D. H., Ghaffari, R., Lu, N. and Rogers, J. A., Annu Rev Biomed Eng 14, 113-128 (2012).CrossRefGoogle Scholar
Patil, A. C. and Thakor, N. V., Med Biol Eng Comput 54 (1), 23-44 (2016).CrossRefGoogle Scholar
Zhang, C. X., Driver, N., Tian, Q. M., Jiang, W. S. and Liu, H. N., J Biomed Mater Res A 106 (7), 1887-1895 (2018).CrossRefGoogle Scholar
Sebaa, M. A., Dhillon, S. and Liu, H., J Mater Sci Mater Med 24 (2), 307-316 (2013).CrossRefGoogle Scholar
Sebaa, M., Nguyen, T. Y., Dhillon, S., Garcia, S. and Liu, H. N., J Biomed Mater Res A 103 (1), 25-37 (2015).CrossRefGoogle Scholar
Jiang, W., Cipriano, A. F., Tian, Q., Zhang, C., Lopez, M., Sallee, A., Lin, A., Cortez Alcaraz, M. C., Wu, Y., Zheng, Y. and Liu, H., Acta Biomater 72, 407-423 (2018).CrossRefGoogle Scholar
Zhang, C. X., Lin, J. J. and Liu, H. N., Mrs Adv 3 (40), 2359-2364 (2018).CrossRefGoogle Scholar
Tian, Q. M., Zhang, C. X., Deo, M., Rivera-Castaneda, L., Masoudipour, N., Guan, R. G. and Liu, H. N., Mater Sci Eng C Mater Biol Appl 96, 248-262 (2019).CrossRefGoogle Scholar
Narita, K., Tian, Q., Johnson, I., Zhang, C., Kobayashi, E. and Liu, H., J Biomed Mater Res B 9999B, 1-16 (2019).Google Scholar
Rotschafer, S. and Razak, K., Brain Res 1506, 12-24 (2013).CrossRefGoogle Scholar