Hostname: page-component-586b7cd67f-2brh9 Total loading time: 0 Render date: 2024-11-26T14:55:06.000Z Has data issue: false hasContentIssue false
  • English
  • Français

Electrospun Fibre Composite for Controlled Drug Release

Published online by Cambridge University Press:  03 June 2020

Ryan Go ,
Shadi Houshyar ,
Kate Fox  and
Yen Bach Truong
Ryan Go
Affiliation:
School of Engineering, RMIT University, Melbourne, Vic3000, Australia
Shadi Houshyar*
Affiliation:
School of Engineering, RMIT University, Melbourne, Vic3000, Australia
Kate Fox
Affiliation:
School of Engineering, RMIT University, Melbourne, Vic3000, Australia Center for Additive Manufacturing, RMIT University, Melbourne, Vic3000, Australia
Yen Bach Truong*
Affiliation:
CSIRO Manufacturing, Private Bag 10, Clayton South, VIC, 3169, Australia.
*
E-mail: [email protected] and [email protected]
E-mail: [email protected] and [email protected]
Get access

Abstract

A drug delivery system with sustainable controlled drug release can improve the quality of life of a patient by reducing the side-effects and better absorption of the drug locally. However, the main disadvantageous of this delivery model is the burst release of the drug, which can result in severe health problem, such as toxicity. Here in this study, a new coaxial microfiber has been developed with encapsulated anti-inflammatory drug, ibuprofen, inside the core structure of the coaxial fibre. The core consisting of polyethylene oxide (PEO) carrying the drug was covered with the polylactic acid (PLA)/PEO and shell to prevent the burst release of the drug and provide sustainable release over a prolonged time. The release profiles showed that the burst release was reduced from 20% in control scaffold, core only, to 5% in core-shell structure after 6 hrs. The higher percentage of PLA in the shell composition provides a slower release of ibuprofen, due to the slower degradation of PLA in comparison with PEO. The result indicates the developed structure can be a potential system for the localized release of the various drug system, which leads to a more sustainable and controlled release of the drug over the more extended period and deliver a better outcome along with side-effect prevention.

Type
Articles
Information
MRS Advances , Volume 5 , Issue 46-47: Soft Materials and Biomaterials , 2020 , pp. 2409 - 2417
Check for updates
Copyright
Copyright © Materials Research Society 2020

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Deng, H., et al. , Synthesis and Controlled Release Behavior of Biodegradable Polymers with Pendant Ibuprofen Group. International Journal of Polymer Science, 2016. 2016: p. 1-8.CrossRefGoogle Scholar
Kajdič, S., et al. , Electrospun nanofibers for customized drug-delivery systems. Journal of Drug Delivery Science and Technology, 2019. 51: p. 672-681.CrossRefGoogle Scholar
Park, K., Controlled drug delivery systems: past forward and future back. J Control Release, 2014. 190: p. 3-8.CrossRefGoogle ScholarPubMed
Qu, F., et al. , A controlled release of ibuprofen by systematically tailoring the morphology of mesoporous silica materials. Journal of Solid State Chemistry, 2006. 179(7): p. 2027-2035.CrossRefGoogle Scholar
Reis, C.P., et al. , Nanoencapsulation I. Methods for preparation of drug-loaded polymeric nanoparticles. Nanomedicine, 2006. 2(1): p. 8-21.CrossRefGoogle ScholarPubMed
Thedrattanawong, C., Manaspon, C., and Nasongkla, N., Controlling the burst release of doxorubicin from polymeric depots via adjusting hydrophobic/hydrophilic properties. Journal of Drug Delivery Science and Technology, 2018. 46: p. 446-451.CrossRefGoogle Scholar
Karki, S., et al. , Thin films as an emerging platform for drug delivery. Asian Journal of Pharmaceutical Sciences, 2016. 11(5): p. 559-574.CrossRefGoogle Scholar
Tran, T.T.D. and Tran, P.H.L., Controlled Release Film Forming Systems in Drug Delivery: The Potential for Efficient Drug Delivery. Pharmaceutics, 2019. 11(6).CrossRefGoogle ScholarPubMed
Costa, J.S.R., de Oliveira Cruvinel, K., and Oliveira-Nascimento, L., A mini-review on drug delivery through wafer technology: Formulation and manufacturing of buccal and oral lyophilizates. J Adv Res, 2019. 20: p. 33-41.CrossRefGoogle ScholarPubMed
Ng, S.F. and Jumaat, N., Carboxymethyl cellulose wafers containing antimicrobials: a modern drug delivery system for wound infections. Eur J Pharm Sci, 2014. 51: p. 173-9.CrossRefGoogle ScholarPubMed
Jalvandi, J., et al. , Release and antimicrobial activity of levofloxacin from composite mats of poly(ɛ-caprolactone) and mesoporous silica nanoparticles fabricated by core–shell electrospinning. Journal of Materials Science, 2015. 50(24): p. 7967-7974.CrossRefGoogle Scholar
Wang, J. and Windbergs, M., Controlled dual drug release by coaxial electrospun fibers - Impact of the core fluid on drug encapsulation and release. Int J Pharm, 2019. 556: p. 363-371.CrossRefGoogle ScholarPubMed
Jalvandi, J., et al. ., Slow release of levofloxacin conjugated on silica nanoparticles from poly(ɛ-caprolactone) nanofibers. International Journal of Polymeric Materials and Polymeric Biomaterials, 2017. 66(10): p. 507-513.CrossRefGoogle Scholar
Lopez Hernandez, H., et al. , Non-Newtonian Polymer-Nanoparticle Hydrogels Enhance Cell Viability during Injection. Macromol Biosci, 2019. 19(1): p. e1800275.CrossRefGoogle ScholarPubMed
Safdar, R., et al. , Potential of Chitosan and its derivatives for controlled drug release applications – A review. Journal of Drug Delivery Science and Technology, 2019. 49: p. 642-659.CrossRefGoogle Scholar
Reed, D.K.G.a.A.M., Biodegradable polymers for use in surgery poly(ethylene oxide) poly(ethylene terephthalate) (PEO/PET) copolymers: 1. POLYMER,, 1979. 20: p. 1454-1458.Google Scholar
Pawar, P., R., et al. ., Biomedical Applications of Poly(Lactic Acid). Recent Patents on Regenerative Medicine, 2014. 4(1): p. 40-51.CrossRefGoogle Scholar
Mahdavinia, G.R., et al. , In vitro evaluation of sustained ciprofloxacin release from kappa-carrageenan-crosslinked chitosan/hydroxyapatite hydrogel nanocomposites. Int J Biol Macromol, 2019. 126: p. 443-453.CrossRefGoogle ScholarPubMed
Jalvandi, J., et al. , Polyvinyl alcohol composite nanofibres containing conjugated levofloxacin-chitosan for controlled drug release. Mater Sci Eng C Mater Biol Appl, 2017. 73: p. 440-446.CrossRefGoogle ScholarPubMed
Bhardwaj, N. and Kundu, S.C., electrospinning: a fascinating fiber fabrication technique. Biotechnol Adv, 2010. 28(3): p. 325-47.CrossRefGoogle ScholarPubMed
Aldawsari, H.M., et al. , Development of a fluvastatin-loaded self-nanoemulsifying system to maximize therapeutic efficacy in human colorectal carcinoma cells. Journal of Drug Delivery Science and Technology, 2018. 46: p. 7-13.CrossRefGoogle Scholar
Ozcan, F., Ertul, S., and Maltas, E., Fabrication of protein scaffold by electrospin coating for artificial tissue. Materials Letters, 2016. 182: p. 359-362.CrossRefGoogle Scholar
Sato, K. and Toriyama, M., The inhibitory effect of non-steroidal anti-inflammatory drugs (NSAIDs) on the monophenolase and diphenolase activities of mushroom tyrosinase. Int J Mol Sci, 2011. 12(6): p. 3998-4008.CrossRefGoogle ScholarPubMed
Jiang, Z.Z.a.J.Q., Detection of iburprofen and Ciprofloxacin by solid-phase extraction and UV/Vis spectroscopry. Journal of Applied Spectroscopy, 2012. 79(3): p. 477–481.Google Scholar
Manrique-Moreno, M., et al. , Biophysical study of the non-steroidal anti-inflammatory drugs (NSAID) ibuprofen, naproxen and diclofenac with phosphatidylserine bilayer membranes. Biochim Biophys Acta, 2016. 1858(9): p. 2123-2131.CrossRefGoogle ScholarPubMed
Shin, S.H., et al. , A short review: Recent advances in electrospinning for bone tissue regeneration. J Tissue Eng, 2012. 3(1): p. 2041731412443530.CrossRefGoogle Scholar
Ganesh, M., et al. , Sulfanilamide and silver nanoparticles-loaded polyvinyl alcohol-chitosan composite electrospun nanofibers: Synthesis and evaluation on synergism in wound healing. Journal of Industrial and Engineering Chemistry, 2016. 39: p. 127-135.CrossRefGoogle Scholar
Silva, C.G., et al. , The influence of treated eucalyptus microfibers on the properties of PLA biocomposites. Composites Science and Technology, 2019. 179: p. 54-62.CrossRefGoogle Scholar
Dasgupta, S. Controlled release of ibuprofen using Mg Al LDH nano carrier. in ICMAEM-2017. 2017.Google Scholar
Supplementary material: File

Go et al. supplementary material

Supplemental information

Download Go et al. supplementary material(File)
File 148 KB