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Electrochemical sensor using carbon nanotube composites for chronic-degenerative diseases diagnosis

Published online by Cambridge University Press:  12 May 2020

Antonio Rowland Ramos-Díaz Open the ORCID record for Antonio Rowland Ramos-Díaz [Opens in a new window] ,
Ramon Gómez Aguilar ,
Hugo Martínez-Gutiérrez  and
Jaime Ortiz-López
Antonio Rowland Ramos-Díaz
Affiliation:
Instituto Politécnico Nacional, ESIQIE, Av. Instituto Politécnico Nacional s/n, 07738Ciudad de México, México.
Ramon Gómez Aguilar
Affiliation:
Instituto Politécnico Nacional, UPIITA, Av. Instituto Politécnico Nacional, 07340Ciudad de México, México.
Hugo Martínez-Gutiérrez
Affiliation:
Instituto Politécnico Nacional, CNMN, Av. Luis Enrique Erro s/n, 07738Ciudad de México, México.
Jaime Ortiz-López
Affiliation:
Instituto Politécnico Nacional, ESFM, Av. Instituto Politécnico Nacional, 07738Ciudad de México, México.
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Abstract

Sensitive and selective detection for cancer biomarkers is critical in cancer clinical diagnostics. In this work, we report an electrochemical detection platform for the carbohydrate antigen tumor marker 15-3 (CA15-3). It is based on a composite material of poly [2-methoxy-5- (2-ethylhexyloxy) -1,4-phenylenevinylene] (MEH-PPV) and multi-walled carbon nanotubes (MWCNT), which deposited as active layer of an organic thin-film transistor. This layer was surface functionalized with the Anti-CA15-3 monoclonal antibody. The devices have a favorable electrical output response for VSD source-drain potentials between 0 to 5 volts, and VG as 8 volts. Once the antigen (CA15-3) is recognized by the antibody, the electrical response is diminished. The test has a linear response in the concentration range of 0–30 U mL - 1 of CA 15–3, with a lower detection limit of ~1 U mL - 1 and a stability of 90% with respect to the initial values after storing the device for two weeks. The method was successfully applied to the determination of CA15-3 in serum samples. Possibly, this used composite material has a greater scope and can be applied to another type of detection scheme.

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Articles
Information
MRS Advances , Volume 5 , Issue 45: Soft Materials and Biomaterials , 2020 , pp. 2331 - 2340
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Copyright
Copyright © Materials Research Society 2020

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