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Mechanically Modulated, Ultra-high Precision Logic Delivery of Molecules by Bio-inspired Macroporous Ceramic Sponge

Published online by Cambridge University Press:  23 January 2017

Changlu Xu ,
Yanjie Bai ,
Huilin Yang  and
Lei Yang
Changlu Xu
Affiliation:
Department of Orthopaedics and Orthopaedic Institute, the First Affiliated Hospital, Soochow University, Suzhou, Jiangsu 215006, P.R. China.
Yanjie Bai
Affiliation:
School of Public Health, Medical College, Soochow University, Suzhou, Jiangsu 215123, P.R. China.
Huilin Yang
Affiliation:
Department of Orthopaedics and Orthopaedic Institute, the First Affiliated Hospital, Soochow University, Suzhou, Jiangsu 215006, P.R. China. International Research Center for Translational Orthopaedics (IRCTO), Soochow University, Suzhou, Jiangsu 215006, P.R. China.
Lei Yang*
Affiliation:
Department of Orthopaedics and Orthopaedic Institute, the First Affiliated Hospital, Soochow University, Suzhou, Jiangsu 215006, P.R. China. International Research Center for Translational Orthopaedics (IRCTO), Soochow University, Suzhou, Jiangsu 215006, P.R. China.
*
*Corresponding author: Lei Yang, Ph.D., Room 313 Building #1, South Campus of Soochow University, 708 Renmin Road, Suzhou, Jiangsu 215006, P.R. China Email: [email protected]; Phone: +86-512-67781540; Fax: +86-512-67781165
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Abstract

Inspired by sea sponges, porous Al2O3/starch composite sponges were designed and fabricated as a new controlled release system enabling mechano-triggered logic delivery of molecules. Results of material characterization indicate that the all the composite sponges had a high macro-porosity of >80%, and dehydrated sponges revealed favorable pore structure for drug loading and retaining. The composite sponges have moisture-dependent mechanical properties and samples with appropriate moisture contents revealed high resilience and mechanical robustness under cyclic deformation. Based on the unique mechanical properties of the composite sponge, mechanically modulated, nano-gram precision delivery of model molecules was achieved in an AND logic manner gated by both moisture and compressive strain.

Keywords

ceramiccellular (material form)biomimetic (assembly)
Type
Articles
Information
MRS Advances , Volume 2 , Issue 19-20: Biomaterials and Soft Materials , 2017 , pp. 1125 - 1130
Copyright
Copyright © Materials Research Society 2017 

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References

REFERENCES

Lee, J., Chen, K., Noh, S., Garcia, M.A., Wang, H., Lin, W., Jeong, H., Kong, B.J., Stout, D.B. and Cheon, J., Angew. Chem. 52, 4384 (2013).CrossRefGoogle Scholar
Nair, M.P.N., Guduru, R., Liang, P., Hong, J., Sagar, V. and Khizroev, S., Nat. Commun. 4, 1707 (2013).Google Scholar
Sjollema, J., Dijkstra, R.J.B., Abeln, C.H., Der Mei, H.C.V., Van Asseldonk, D.P. and Busscher, H.J., J. Control. Release 188, 61 (2014).CrossRefGoogle Scholar
Yuan, Y., Liu, J. and Liu, B., Angew. Chem. 53, 7163 (2014).Google Scholar
Ruvinov, E., Leor, J. and Cohen, S., Biomaterials 32, 565 (2011).CrossRefGoogle Scholar
Qiu, Y. and Park, K., Adv. Drug Delivery Rev. 53, 321 (2001).Google Scholar
Bawa, P., Pillay, V., Choonara, Y.E. and Du Toit, L.C., Biomed. Mater. 4, 022001 (2009).Google Scholar
Mura, S., Nicolas, J. and Couvreur, P., Nat. Mater. 12, 991 (2013).Google Scholar
Lee, K.Y., Peters, M.C., Anderson, K.W. and Mooney, D.J., Nature 408, 998 (2000).Google Scholar
Zhao, X., Kim, J., Cezar, C.A., Huebsch, N., Lee, K., Bouhadir, K.H. and Mooney, D.J., PNAS 108, 67 (2011).Google Scholar
Wang, J., Kaplan, J.A., Colson, Y.L. and Grinstaff, M.W., Adv. Drug Delivery Rev. doi.org/10.1016/j.addr.2016.11.001.Google Scholar
Duan, C.Y., Cui, G., Xu, X.B. and Liu, P.S., Appl. Acoust. 73, 865 (2012).Google Scholar
Xu, C.L., Liu, H.R., Yang, H.L. and Yang, L., J. Mater. Sci. Technol. 32, 729 (2016).Google Scholar