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Hydroxyapatite Nanocrystal Deposited Titanium Dioxide Nanotubes Loaded with Antibiotics for Combining Biocompatibility and Antibacterial Properties

Published online by Cambridge University Press:  28 January 2018

Xuefei Zhang ,
Yuan Zhang  and
Matthew Z. Yates
Xuefei Zhang*
Affiliation:
Materials Science Program, University of Rochester, Rochester, NY14627, USA
Yuan Zhang
Affiliation:
Department of Chemical Engineering, University of Rochester, Rochester, NY14627, USA
Matthew Z. Yates
Affiliation:
Department of Chemical Engineering, University of Rochester, Rochester, NY14627, USA
*
*(Email: [email protected])
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Abstract

Hydroxyapatite (HA)/nanotubular titanium dioxide (TiO2) composite coatings loaded with antibiotics were developed to combine biocompatibility and antibacterial property. TiO2 nanotubes were first fabricated on Ti plates using anodization techniques. Then HA nanocrystals were synthesized on the TiO2 nanotubes by electrochemical deposition, followed by loading of a model drug compound, streptomycin. The streptomycin release profile of the composite coating was investigated. Bacterial tests demonstrate that the streptomycin-loaded composite coatings were highly effective in inhibiting bacterial growth. Simulated body fluid (SBF) experiments indicated that the composite coatings possessed good osseointegration capability.

Keywords

biomaterialcoatingelectrochemical synthesis
Type
Articles
Information
MRS Advances , Volume 3 , Issue 30: Biomaterials and Soft Materials , 2018 , pp. 1703 - 1709
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Copyright
Copyright © Materials Research Society 2018 

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References

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