Hostname: page-component-586b7cd67f-g8jcs Total loading time: 0 Render date: 2024-11-26T06:14:47.542Z Has data issue: false hasContentIssue false
  • English
  • Français

Development of a Flexible MIP-Based Biosensor Platform for the Thermal Detection of Neurotransmitters

Published online by Cambridge University Press:  05 January 2018

Kai Betlem ,
Michael P. Down ,
Christopher W. Foster ,
Shamima Akthar ,
K. Eersels ,
B. van Grinsven ,
T.J. Cleij ,
C.E. Banks  and
M. Peeters
Kai Betlem
Affiliation:
Manchester Metropolitan University, Faculty of Science and Engineering, Div. of Chemistry & Environmental Science, John Dalton Building, Chester Street, M15GD, Manchester, United Kingdom.
Michael P. Down
Affiliation:
Manchester Metropolitan University, Faculty of Science and Engineering, Div. of Chemistry & Environmental Science, John Dalton Building, Chester Street, M15GD, Manchester, United Kingdom.
Christopher W. Foster
Affiliation:
Manchester Metropolitan University, Faculty of Science and Engineering, Div. of Chemistry & Environmental Science, John Dalton Building, Chester Street, M15GD, Manchester, United Kingdom.
Shamima Akthar
Affiliation:
Manchester Metropolitan University, Faculty of Science and Engineering, Div. of Chemistry & Environmental Science, John Dalton Building, Chester Street, M15GD, Manchester, United Kingdom.
K. Eersels
Affiliation:
Maastricht University, Maastricht Science Programme, P.O. Box 616, 6200MD Maastricht, The Netherlands.
B. van Grinsven
Affiliation:
Maastricht University, Maastricht Science Programme, P.O. Box 616, 6200MD Maastricht, The Netherlands.
T.J. Cleij
Affiliation:
Maastricht University, Maastricht Science Programme, P.O. Box 616, 6200MD Maastricht, The Netherlands.
C.E. Banks
Affiliation:
Manchester Metropolitan University, Faculty of Science and Engineering, Div. of Chemistry & Environmental Science, John Dalton Building, Chester Street, M15GD, Manchester, United Kingdom.
M. Peeters*
Affiliation:
Manchester Metropolitan University, Faculty of Science and Engineering, Div. of Chemistry & Environmental Science, John Dalton Building, Chester Street, M15GD, Manchester, United Kingdom.
*
*(Email: [email protected])
Get access

Abstract

We have developed high affinity Molecularly Imprinted Polymers (MIPs) for neurotransmitters such as dopamine, noradrenaline and caffeine. These polymer particles are mixed within the bulk of screen-printed ink allowing masss-producible bulk modified MIP Screen-Printed Electrodes (MIP-SPEs) to be realised. We have explored different SPE supporting surfaces, such as polyester, tracing paper and household-printing paper. The performance of those MIP-SPEs is studied using the Heat-Transfer Method (HTM), a patented thermal method. With the combination of screen-printing techniques and thermal detection, it is possible to develop a portable sensor platform that is capable of low-cost and straightforward detection of biomolecules on-site. In the future, this unique sensor architecture holds great promise for the use in biomedical devices.

Keywords

sensorpolymerbiomimetic (chemical reaction)
Type
Articles
Information
MRS Advances , Volume 3 , Issue 28: Biomaterials and Soft Materials , 2018 , pp. 1569 - 1574
Check for updates
Copyright
Copyright © Materials Research Society 2017 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Haupt, K. and Mosbach, K., Chem. Rev. 100, 2495 (2000).Google Scholar
Wulff, G., Chem. Rev. 102, 1, (2002).Google Scholar
Spivak, D. A., Adv. Drug. Del. Rev. 57, 1779, (2005).Google Scholar
Casadio, S., Lowdon, J.W., Betlem, K., Ueta, J.T., Foster, C.W., Cleij, T.J., van Grinsven, B., Sutcliffe, O.B., Banks, C.E. and Peeters, M., Chem. Eng. J. 315, 459, (2017).Google Scholar
van Grinsven, B, Eersels, K., Peeters, M., Losada-Perez, P., Vandenryt, T., Cleij, T.J. and Wagner, P., ACS Appl. Mater. Interfaces, 6, 16, 13309, (2014).Google Scholar
Ye, L., Cormack, P.A.G. and Mosbach, K., Anal. Commun, 36, 35, (1999).Google Scholar