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Mechanics of osteoporotic trabecular bone

Published online by Cambridge University Press:  22 November 2012

Maxime Bérot ,
Jean-Charles Aurégan ,
Laurianne Imbert ,
Hélène Magoariec ,
Elisa Budyn ,
Frédéric Zadegan ,
Didier Hannouche ,
Morad Bensidhoum  and
Thierry Hoc
Maxime Bérot
Affiliation:
LTDS, UMR 5513, École Centrale de Lyon, 36 Av. Guy de Collongue, 69134 Écully, France MSSMAT, UMR 8579, École Centrale Paris, Grande Voie des Vignes, 92295 Chatenay-Malabry, France
Jean-Charles Aurégan
Affiliation:
B2OA, UMR 7052, Université Paris Diderot, 10 avenue de Verdun, 75010 Paris, France
Laurianne Imbert
Affiliation:
LTDS, UMR 5513, École Centrale de Lyon, 36 Av. Guy de Collongue, 69134 Écully, France
Hélène Magoariec
Affiliation:
LTDS, UMR 5513, École Centrale de Lyon, 36 Av. Guy de Collongue, 69134 Écully, France
Elisa Budyn
Affiliation:
UIC Department of Mechanical Engineering, University of Illinois at Chicago, 842 West Taylor Street, Chicago, IL 60607, USA
Frédéric Zadegan
Affiliation:
B2OA, UMR 7052, Université Paris Diderot, 10 avenue de Verdun, 75010 Paris, France
Didier Hannouche
Affiliation:
B2OA, UMR 7052, Université Paris Diderot, 10 avenue de Verdun, 75010 Paris, France
Morad Bensidhoum
Affiliation:
B2OA, UMR 7052, Université Paris Diderot, 10 avenue de Verdun, 75010 Paris, France
Thierry Hoc*
Affiliation:
LTDS, UMR 5513, École Centrale de Lyon, 36 Av. Guy de Collongue, 69134 Écully, France
*
a Corresponding author:[email protected]
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Abstract

Osteoporosis is a disease characterized by a loss of bone density and an altered bonearchitecture. These modifications lead to an increased risk factor for bone fracture,particularly of the femoral neck. This disease can be explained by a disorder in the boneremodeling process which is triggered by the apparition of micro-cracks within the bone.According to Frost’s theory [1], these micro-cracksappear for a specific local strain threshold. Thus, the knowledge of the microarchitectureand quality of trabecular bone is essential to determine this local strain threshold. Thispaper studied the mechanical trabecular bone behavior of 43 patients diagnosed asosteoporotic whose femoral heads were replaced by hip prosthesis. From each patient, acylinder-shaped of trabecular bone samples was cored. Each sample was scanned by X-raymicro-tomography before a compression test in order to reconstruct a reliableFinite-Element (FE) model of the bone architecture in Abaqus. The force-displacementcurves were recorded for all the samples and calibrated by the experimental responses. Theforce-displacement numerical curves were adjusted to the experimental ones, by modifyingthe tissue microscopic mechanical behavior. This process leads to the determination of thelocal strain threshold responsible for triggering the bone remodeling process.

Keywords

Trabecular boneosteoporosismicromechanicsbone remodelingX-ray microtomographyfinite-element methodOs trabéculaireostéoporosemicromécaniqueremodelage osseuxmicrotomographie aux rayons Xméthode des éléments-finis
Type
Research Article
Information
Mechanics & Industry , Volume 13 , Issue 6: Giens 2011 , 2012 , pp. 373 - 380
Copyright
© AFM, EDP Sciences 2012

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