Tile systems offer a general paradigm for modular descriptions of concurrent systems, based on a set of rewriting rules with side-effects. Monoidal double categories are a natural semantic framework for tile systems, because the mathematical structures describing system states and synchronizing actions (called configurations and observations, respectively, in our terminology) are monoidal categories having the same objects (the interfaces of the system). In particular, configurations and observations based on net-process-like and term structures are usually described in terms of symmetric monoidal and cartesian categories, where the auxiliary structures for the rearrangement of interfaces correspond to suitable natural transformations. In this paper we discuss the lifting of these auxiliary structures to double categories. We notice that the internal construction of double categories produces a pathological asymmetric notion of natural transformation, which is fully exploited in one dimension only (for example, for configurations or for observations, but not for both). Following Ehresmann (1963), we overcome this biased definition, introducing the notion of generalized natural transformation between four double functors (rather than two). As a consequence, the concepts of symmetric monoidal and cartesian (with consistently chosen products) double categories arise in a natural way from the corresponding ordinary versions, giving a very good relationship between the auxiliary structures of configurations and observations. Moreover, the Kelly–Mac Lane coherence axioms can be lifted to our setting without effort, thanks to the characterization of two suitable diagonal categories that are always present in a double category. Then, symmetric monoidal and cartesian double categories are shown to offer an adequate semantic setting for process and term tile systems.