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Mathematical model of tumour cord growthalong the source of nutrient

Published online by Cambridge University Press:  15 June 2008

S. Astanin
Affiliation:
Dipartimento di Matematica, Politecnico di Torino, Corso Duca degli Abruzzi 24, Turin, 10129, Italy
A. Tosin*
Affiliation:
Dipartimento di Matematica, Politecnico di Torino, Corso Duca degli Abruzzi 24, Turin, 10129, Italy
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Abstract

A mathematical model of the tumour growth along a blood vessel is proposed. Themodel employs the mixture theory approach to describe a tissue which consists of cells, extracellularmatrix and liquid. The growing tumour tissue is supposed to be surrounded by the hosttissue. Tumours where complete oxydation of glucose prevails are considered. Special attention ispaid to consistent description of oxygen consumption and growth processes based on the energybalance. A finite difference numerical method is proposed. The level set method is used to trackan interface between the tissues. The simulations show localization of the tumour within a limiteddistance from the vessels and constant expansion velocity along the vessels.

Type
Research Article
Copyright
© EDP Sciences, 2007

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