China, which was once a world champion in invention, has failed to maintain its global leadership in innovation after the middle of the Ming Dynasty (1368–1644). Today, frame-breaking innovations are more likely to originate from European and North American countries than from China. In the perspective article (Augier, Guo, & Rowen, 2016), the authors attribute this phenomenon, which is often referred to as the Needham Puzzle, to three reasons: (1) the Chinese did not develop a scientific method like that in the West; (2) lack of educational diversity and structural inertia in China; and (3) lack of openness to the outside world. The authors also attribute the US's leadership in innovation to its culture of encouraging experimentation, tolerating failure and accepting deviance, and to its institutional support for decentralization of and competition in R&D and basic research. This commentary aims to enrich this insightful analysis. We focus on (1) the reasons for the demise of Chinese leadership in science and technology since the middle of the Ming dynasty, and (2) the historical and cultural obstacles to the development of frame-breaking innovations in modern China.