Wide north-south transplants were made with three lichen species, Parmelia cumberlandia, Cladonia turgida and Stereocaulon saxarile. The objective was to determine whether thallus chemistry would be altered due to wide geographic displacement of thallus segments from the control locations. Significant quantitative variation in microchemistry was observed among thalli of P. cumberlandia and among those of C. turgida, but there were no qualitative or quantitative effects on the lichen products, usnic acid, atranorin, constictic, stictic, norstictic, fumarprotocetraric and lobaric acids, due to transplantation.