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Antiprogestin Drugs: Research and Clinical Use in Sweden

Published online by Cambridge University Press:  29 April 2021

Marc Bygdeman  and
Marja-Liisa Swahn
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Extract

Progesterone is essential both for ovulation and for the formation of the secretory endometrium which is required for nidation: it plays a central role in the establishment and maintenance of pregnancy. Given the multifaceted role of progesterone in the reproductive process, an anti-progestational compound such as RU 486 (Mifepristone, Roussel-Uclaf, Paris, France) could be expected to have a number of potential clinical applications in human fertility regulation including termination of pregnancy, induction of missed menses, postcoital contraception and inhibition of ovulation and implantation.

Our research and clinical evaluation have mainly been directed to termination of pregnancy and to inhibition of implantation. The aim of this presentation is to summarize briefly our experience with the use of RU 486 in these areas.

Type
Medical and Health Services Issues
Information
Law, Medicine and Healthcare , Volume 20 , Issue 3 , Fall 1992 , pp. 157 - 160
Copyright
© 1992 American Society of Law, Medicine & Ethics

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References

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