This article is concerned with understanding situations in which speakers talk in the presence of scientific inscriptions (lectures in science classes, public presentations). Drawing on extensive video materials accumulated in middle and high school science classrooms and university lectures, we develop a framework for the resources speakers make available to their audience for understanding what the talk is about. We distinguish three situations according to the nature of reference to the phenomenon talked about: (i) talk is about phenomenon but mediated by reference to a two-dimensional (2-D) inscription; (ii) talk is about phenomenon but mediated by reference to a three-dimensional (3-D) inscription; and (iii) talk is directly about phenomenon. Associated with these three situations are different body orientations, distances from inscriptions, and types of gestures. When speakers laminate talk characteristic of two different types of situations, the orientation “up” can become “down” and “down” can become “up,” potentially leading to confusing statements.